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New study aims to help ventilator patients breathe on their own faster

NCT ID NCT07353814

Symptom relief Sponsor: Cairo University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
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Not open to general applications. Only people the study team invites can take part.
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The trial has finished. Results may not be published yet.
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Stopped early, before it reached the end. That can be for many reasons, including safety.
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Cancelled before anyone took part.

Expanded access (not trials)

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Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
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Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests two methods to train the breathing muscles of patients with respiratory failure who are on mechanical ventilators. One method slowly increases the effort needed to trigger a breath, while the other gradually reduces the machine's support. The goal is to see which approach helps patients wean off the ventilator and breathe independently more successfully. The study will include 60 adults aged 40-55 who are stable enough to try spontaneous breathing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2026

An estimate. Start dates often move.

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 55 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Acute respiratory failure patients in the ICU are receiving MV for 48 h or more in a controlled mode. * Their ages will range from 40 to 55 years old, and both sexes will be included. * Conscious and oriented patients with a Glasgow coma score ≥13 (≥9T). * Alertness score with a Richmond Agitation-Sedation Scale (RASS) will be from 0 to -1. * All patients in this study must be hemodynamically and medically stable. * Patients must be able to trigger spontaneous breaths on the ventilator but couldn't generate maximum inspiratory pressure more than -15 mbar. Exclusion Criteria: * Persistent hemodynamic instability as life-threatening conditions or comorbidities interfere with and compromise weaning, like cardiac arrhythmia, pericardial effusion, congestive heart failure, or acute coronary syndrome. * Severe breathlessness when spontaneously breathing. * Any progressive neuromuscular disease, such as myopathy or neuropathy, that would interfere with responding to inspiratory muscle training due to inadequate training performance of the inspiratory muscle. * Spinal cord injury. * Skeletal pathology (scoliosis, flail chest, spinal instrumentation) that would seriously impair the movement of the chest wall and ribs. * Patients in a coma or under heavy sedation (RASS ≤ -2) and with respiratory muscle paralysis. * High peak airway pressure (barotrauma), high PEEP \>10, or active pneumothorax.

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Conditions

The condition(s) this trial relates to.

acute respiratory failure respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mechanical ventilation complication Respiratory failure

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • kasr Al Ainy Hospital

    Cairo, Giza Governorate, 11956, Egypt

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