ACUTE RESPIRATORY FAILURE

This study compared two common sedatives, ketamine and etomidate, used when critically ill adults need a breathing tube placed in an emergency. About 2,367 patients took part to see which drug leads to fewer deaths and heart problems. The goal is to find the safer option for this…

This study tested whether giving high-flow heated oxygen through nasal prongs helps more people survive severe breathing failure than standard oxygen masks. Over 1,500 adults with low blood oxygen levels were randomly assigned to one of the two oxygen methods. The main goal was t…

This study tested whether using a mask that helps with breathing (non-invasive ventilation) can prevent the need for a breathing tube in patients who develop respiratory failure after abdominal surgery. 300 adults who had abdominal surgery and then had trouble breathing were rand…

This study explores whether ultrasound can identify the reasons some patients fail to come off a mechanical ventilator. Researchers will scan the heart, lungs, and diaphragm of adults who have been on a ventilator for at least 24 hours and have not passed a spontaneous breathing …

This study tested whether physiotherapy (special breathing exercises and early movement) could prevent acute respiratory failure within 7 days after a breathing tube is removed in ICU patients at high risk. 245 patients took part. The goal was to see if physiotherapy reduces the …

This study tested a team-based approach to managing sedation in children with acute respiratory failure who need a breathing machine. The goal was to reduce the number of days on the ventilator. Over 2,400 children from multiple hospitals participated, comparing the team approach…

This study looked at whether giving the drug salbutamol (often used in asthma inhalers) through a nebulizer helps people with severe COPD who are having a flare-up and need a breathing machine. The trial included 43 adults and compared the drug to a placebo. The main goal was to …

This pilot study tested whether a therapy that combines behavioral activation for depression with physical rehabilitation is feasible for survivors of acute respiratory failure. Fifty-two adults who had been on life support in the ICU received home visits and phone calls from the…

This study looks at how breathing machines (mechanical ventilators) might injure the diaphragm, the main muscle used for breathing. Researchers will monitor 50 ICU patients over their first 7 days on the ventilator, measuring diaphragm activity and function. The goal is to unders…

This study aimed to predict whether high-flow nasal oxygen therapy would fail within 30 minutes for patients with acute respiratory failure. Researchers used data from 164 participants, including a special imaging technique called electrical impedance tomography, to build a predi…

This study looked at 500 adults on breathing machines to see if measuring airway pressure at a specific moment (P1) versus a later moment (P2) better predicts lung damage. The goal is to find which measurement helps doctors set safer ventilator settings. No new treatment was test…

This study observed over 4,000 patients in Chinese ICUs who needed breathing support for acute respiratory failure. Researchers tracked treatments, outcomes, and costs to better understand the disease burden. The goal is to improve care and identify risk factors, not to test a ne…

This study tested a new way to predict if patients on breathing machines can safely have the tube removed. Researchers used a special imaging technique called electrical impedance tomography (EIT) to measure how well the lungs fill with air during a breathing trial. The goal was …

This study compared two common sedatives, propofol and ketamine, used when placing a breathing tube in critically ill patients. Researchers wanted to see which drug better keeps blood pressure stable after the procedure. The trial involved 207 adults in intensive care who needed …

This study looked at whether giving nutrition through a tube into the stomach (enteral) or through a vein (parenteral) early on affects survival in very sick patients who need a breathing machine and heart-support medications. Over 2,400 adults in intensive care units were random…

This study tested whether giving high-flow oxygen through the nose just before removing a breathing tube is safe and acceptable for patients in intensive care with severe breathing problems. Only 2 patients took part, and the main goal was to see if a larger study is possible. Th…

This completed study looked at 55 adults with acute respiratory failure to understand how their breathing, diaphragm, and lung ventilation relate to the need for a breathing tube. Researchers used ultrasound and electrical imaging to measure diaphragm movement and lung function. …

This completed study tested whether a telemedicine-based program could improve quality of life for adults who needed a breathing machine (ventilator) due to acute respiratory failure. The program included rehabilitation strategies during the ICU stay, hospital ward, and for two m…

This study examined over 1,200 adults admitted to an intensive care unit to see if the reason they were admitted (like sepsis or breathing failure) could predict their risk of dying in the ICU, beyond what standard severity scores show. Researchers looked back at medical records …

This study looked at 600 COVID-19 patients with severe breathing problems who were treated with high-flow nasal oxygen and asked to lie face-down (awake prone position). The goal was to see if this combination reduced the need for a breathing tube and lowered death rates. Researc…

This study surveyed 534 physicians worldwide to understand how they use humidification (adding moisture to air) when treating hospitalized adults with non-invasive ventilation (breathing support through a mask). The goal was to find out how often humidification is used, what type…

This study tested a personalized online decision-support tool called TRACH-Support. The tool is designed to help families and doctors make shared decisions about tracheostomy and prolonged mechanical ventilation. Researchers enrolled 105 participants, including family members of …

This study looked at 16 adults with acute respiratory failure who were on a type of breathing machine called pressure-support ventilation. Researchers compared three different methods to measure the risk of lung injury caused by the ventilator itself. The goal was to see which me…

This study tested three different ways to manage pain and sedation in 90 adults on breathing machines (mechanical ventilation) for at least 48 hours. The goal was to see which approach was most practical and how it affected time in the ICU. The study did not aim to cure or treat …

This study tracked 862 adults in intensive care who had high carbon dioxide levels in their blood (hypercapnia). Researchers aimed to learn how common this condition is, what causes it, and how it affects patient outcomes. No new treatment was tested; instead, the goal was to gat…