Could a simple oxygen change help ICU patients breathe easier after tube removal?

NCT ID NCT05904652

Completed Knowledge-focused Sponsor: NHS Greater Glasgow and Clyde Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether giving high-flow oxygen through the nose just before removing a breathing tube is safe and acceptable for patients in intensive care with severe breathing problems. Only 2 patients took part, and the main goal was to see if a larger study is possible. The researchers compared this new approach to standard low-flow oxygen given after tube removal.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: High flow nasal oxygen delivery device
What this could lead to: If successful, this could lead to a larger trial testing whether high-flow oxygen before tube removal reduces the need for re-intubation.
What could go wrong: This is a very small feasibility study with only 2 participants, so results are not generalizable. It is designed to test recruitment and safety, not effectiveness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ACUTE RESPIRATORY FAILURE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

acute respiratory failure respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RESPIRATORY INSUFFICIENCY

Contacts and locations

Locations

Department of Critical Care Medicine, Queen Elizabeth University Hospital

Glasgow, Scotland, G51 4TF, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.