Breathing machine may harm diaphragm: new study investigates

NCT ID NCT03108118

Completed Knowledge-focused Sponsor: University Health Network, Toronto Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how breathing machines (mechanical ventilators) might injure the diaphragm, the main muscle used for breathing. Researchers will monitor 50 ICU patients over their first 7 days on the ventilator, measuring diaphragm activity and function. The goal is to understand why some patients develop diaphragm weakness and how to prevent it.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help doctors understand how to adjust ventilator settings to reduce diaphragm injury in critically ill patients.
What could go wrong: This is a small observational study with only 50 participants, so results may not apply to all patients. It does not test any treatment, so no direct benefit is expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute respiratory failure injury respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIAPHRAGM INJURY MECHANICAL VENTILATION COMPLICATION RESPIRATORY INSUFFICIENCY

Contacts and locations

Locations

Mount Sinai Hospital

Toronto, Ontario, M5G 1X5, Canada
University Health Network

Toronto, Ontario, M5G 2N2, Canada

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