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Can a full-body rehab program help patients break free from the ventilator?

NCT ID NCT04021615

Disease control Sponsor: Sherin Hassan Mohammed Mehani Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This trial tests whether a comprehensive rehabilitation program that includes muscle training and functional exercises can help patients wean off mechanical ventilation more successfully than traditional chest physiotherapy. The study enrolls conscious, stable patients who have already failed one attempt to breathe on their own. Researchers will measure weaning success, respiratory muscle strength, and overall functional status.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
comprehensive physical therapy rehabilitation program combined with inspiratory muscle training
What this could lead to
If it works, this could point toward a more effective way to help patients breathe on their own after being on a ventilator.
What could go wrong
This is a relatively small trial, and results may not apply to all ventilator patients. The intervention requires patient cooperation, which may limit its use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

90 people

The number who actually took part.

Started

Jul 2019

Finished

Jan 2020

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * The general surgery patients who fail one weaning attempt of spontaneous breathing trial * Conscious patients * Hemodynamically stable patients (lack of hypotension or a need for only low-dose pressors) * The patients with Acute Physiology and Chronic Health Evaluation II (APACHE II) scale 20 or less Exclusion Criteria: * patients with persistent altered sensorium * patients with major cardiac arrhythmia * patients with comorbid medical conditions (e.g., neurological diseases) or who are under any sedative or paralytic agents that would interfere with strength measurements and limb exercises * patients with history of underlying neuromuscular disease or acquired polyneuromyopathies * patients who are unable to perform physical training due to preexisting joint dysfunction * obese patients

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mechanical ventilation complication

Contacts and locations

Locations

  • surgical intensive care unit, Kasr Al Ainy Teaching Hospital, Cairo University and Beni- Suef Teaching Hospital , Beni -Suef University.

    Cairo, Cairo Governorate, 62511, Egypt

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