Ultrasound could reveal hidden diaphragm weakness in ventilator patients

NCT ID NCT03129217

Completed Knowledge-focused Sponsor: University Health Network, Toronto Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study investigates whether a specific ultrasound measurement—called maximal diaphragm thickening fraction—can accurately assess diaphragm function in patients who are on mechanical ventilation. Researchers will compare this ultrasound technique to a standard method (phrenic nerve stimulation) in adults who are ready to try breathing on their own. If validated, this non-invasive approach could help doctors better predict when patients can safely be taken off the ventilator.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could provide a simple, non-invasive way to assess diaphragm strength in ventilated patients, helping doctors decide when to remove breathing support.
What could go wrong: This is a small, early-stage study focused on validating a measurement technique. It may not translate into better patient outcomes or apply to all ventilator patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIAPHRAGM INJURY MECHANICAL VENTILATION COMPLICATION WEANING FAILURE

Contacts and locations

Locations

University Health Network

Toronto, Ontario, M5G 2N2, Canada

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