Could a common anesthetic gas help ICU patients breathe better on ventilators?
NCT ID NCT06014138
First seen Jun 08, 2026 · Last updated Jun 23, 2026 · Updated 4 times
Summary
This study looks at how different sedatives affect the breathing of patients with acute respiratory distress syndrome (ARDS) who are on a ventilator. Twenty adults in the ICU will receive both standard intravenous propofol and inhaled isoflurane (a gas used in anesthesia) for short periods. Researchers will measure breathing drive and effort to see if one approach helps patients breathe more naturally while on the machine.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Guy's & St Thomas' NHS Foundation Trust
RECRUITINGLondon, London, SE1 9RT, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Isoflurane (inhaled volatile sedation) compared to propofol (intravenous sedation)
What this could lead to
If it works, this could point toward better sedation methods that preserve natural breathing in ICU patients with lung injury.
What could go wrong
This is a very small early-phase study with only 20 participants, so results may not apply broadly. The intervention is short-term and only measures physiological changes, not long-term outcomes.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.