Could a common anesthetic gas help ICU patients breathe better on ventilators?

NCT ID NCT06014138

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study looks at how different sedatives affect the breathing of patients with acute respiratory distress syndrome (ARDS) who are on a ventilator. Twenty adults in the ICU will receive both standard intravenous propofol and inhaled isoflurane (a gas used in anesthesia) for short periods. Researchers will measure breathing drive and effort to see if one approach helps patients breathe more naturally while on the machine.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
Isoflurane (inhaled volatile sedation) compared to propofol (intravenous sedation)
What this could lead to
If it works, this could point toward better sedation methods that preserve natural breathing in ICU patients with lung injury.
What could go wrong
This is a very small early-phase study with only 20 participants, so results may not apply broadly. The intervention is short-term and only measures physiological changes, not long-term outcomes.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Guy's & St Thomas' NHS Foundation Trust

    RECRUITING

    London, London, SE1 9RT, United Kingdom

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