Team sedation strategy may shorten ventilator time for kids

NCT ID NCT00814099

Completed Symptom relief Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a team-based approach to managing sedation in children with acute respiratory failure who need a breathing machine. The goal was to reduce the number of days on the ventilator. Over 2,400 children from multiple hospitals participated, comparing the team approach to usual care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: team approach to sedation management
What this could lead to: If successful, this approach could shorten the time children need a breathing machine, reducing hospital stays and risks.
What could go wrong: This is a completed study, so results are known. The approach may not work for all children or in all hospitals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute lung injury acute respiratory failure lung disorder newborn respiratory distress syndrome Respiratory Distress Syndrome, Newborn respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG DISEASES RESPIRATORY DISTRESS SYNDROME, NEWBORN RESPIRATORY INSUFFICIENCY

Contacts and locations

Locations

Advocate Hope Children's Hospital

Oak Lawn, Illinois, 60453, United States
C. S. Mott Children's Hospital of the University of Michigan

Ann Arbor, Michigan, 48109-0243, United States
Children's Hospital and Research Center at Oakland

Oakland, California, 94609-1809, United States
Children's Hospital at University of California San Francisco Medical Center

San Francisco, California, 94143, United States
Children's Hospital of Alabama

Birmingham, Alabama, 35233, United States
Children's Hospital of Orange County

Orange, California, 92868, United States
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
Children's Medical Center Dallas

Dallas, Texas, 75235, United States
Children's Memorial Hospital, Chicago

Chicago, Illinois, 60614-3363, United States
Children's Mercy Hospital, Kansas City

Kansas City, Missouri, 84108, United States
Cohen Children's Medical Center of New York

New Hyde Park, New York, 11040, United States
Connecticut Children's Medical Center

Hartford, Connecticut, 06106, United States
Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, 03756-0001, United States
Doernbecher Children's Hospital

Portland, Oregon, 97239, United States
Duke Children's Hospital and Health Center

Durham, North Carolina, 27710, United States
Florida Hospital for Children

Orlando, Florida, 32803, United States
Holtz Children's Hospital

Miami, Florida, 33136, United States
Johns Hopkins Children's Center

Baltimore, Maryland, 21287, United States
Lucile Salter Packard Children's Hospital at Stanford

Palo Alto, California, 94304-0126, United States
Medical City Children's Hospital

Dallas, Texas, 75230, United States
Monroe Carell, Jr. Children's Hospital at Vanderbilt

Nashville, Tennessee, 37232-9075, United States
Nemours/Alfred I. duPont Hospital for Children

Wilmington, Delaware, 19803, United States
Primary Children's Medical Center

Salt Lake City, Utah, 84113, United States
St. Louis Children's Hospital

St Louis, Missouri, 63110, United States
The Children's Hospital at Montefiore

The Bronx, New York, 10467, United States
University Medical Center, The University of Arizona

Tucson, Arizona, 85724, United States
University of California Davis Medical Center

Sacramento, California, 95817, United States
University of Maryland Hospital for Children

Baltimore, Maryland, 21201-1595, United States
University of Massachusetts Memorial Children's Medical Center

Worcester, Massachusetts, 01655, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68114, United States
Yale-New Haven Children's Hospital

New Haven, Connecticut, 06520-8064, United States

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