Which oxygen strategy saves more lives? large trial puts three methods to the test

NCT ID NCT05812911

Terminated Disease control Sponsor: University Hospital, Montpellier Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial tests whether high-flow nasal cannula oxygen or noninvasive ventilation works better than standard oxygen therapy for ICU patients with acute respiratory failure. About 1,470 adults will be randomly assigned to one of the three methods. The main goal is to see which approach lowers the chance of death within 28 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: oxygen therapy (high-flow nasal cannula, noninvasive ventilation, standard oxygen)
What this could lead to: If one method proves superior, it could become the standard approach to help more ICU patients survive acute respiratory failure.
What could go wrong: The trial is large but results may show no clear winner, or benefits may not apply to all types of respiratory failure. Risks include discomfort or injury from the devices.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE RESPIRATORY FAILURE

Contacts and locations

Locations

Montpellier University Hospital - Saint Eloi Hospital

Montpellier, 34295, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.