Could early norepinephrine save more septic shock patients?

NCT ID NCT07343206

Recruiting now Disease control Sponsor: Siriraj Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving the drug norepinephrine early and adjusting the dose quickly can improve survival in adults with septic shock. Researchers will compare this approach to standard care with a placebo. Six hundred participants will be monitored for 28 days to see if early treatment reduces deaths and speeds recovery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: norepinephrine
What this could lead to: If it works, this could establish a better way to treat septic shock, potentially saving more lives by stabilizing blood pressure faster.
What could go wrong: This is a single trial with 600 participants. Results may not apply to all patients, and norepinephrine can cause side effects like limb ischemia.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hypotensive disorder infectious disease with sepsis Sepsis toxic shock syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEPSIS SEPTIC SHOCK

Contacts and locations

Locations

Faculty of Medicine Siriraj Hospital, Mahidol University
RECRUITING

Bangkok Noi, Bangkok, 10700, Thailand
Hatyai Hospital
RECRUITING

Hat Yai, Hat Yai, 90110, Thailand
Kalasin Hospital
RECRUITING

Kalasin, Changwat Kalasin, 46000, Thailand
Khon Kaen hospital
RECRUITING

Khon Kaen, Changwat Khon Kaen, 4000, Thailand
Maharaj Nakhon Si Thammarat Hospital
RECRUITING

Nakhon Si Thammarat, ์Nakhon Si Thammarat, 8000, Thailand
Udon Thani Hospital
RECRUITING

Udon Thani, Changwat Udon Thani, 41000, Thailand

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