Could a simple CO2 test save lives in septic shock?

NCT ID NCT07179276

Recruiting now Knowledge-focused Sponsor: University Hospital, Clermont-Ferrand Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two methods for guiding early treatment in people with septic shock, a severe infection that can cause organ failure. The standard approach uses blood lactate levels, but this trial tests whether using the CO2 gap (a measure of blood flow) is better at reducing deaths. About 750 adults in intensive care will take part, and the main goal is to see if more people survive at 28 days.

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Conditions

The condition(s) this trial relates to.

infectious disease with sepsis Sepsis toxic shock syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEPSIS - TO REDUCE MORTALITY IN THE INTENSIVE CARE UNIT SEPTIC SHOCK

Contacts and locations

Locations

AP HM Hôpital la Timone
RECRUITING

Marseille, France
APHP Beaujon
RECRUITING

Paris, France
APHP Bicêtre
RECRUITING

Paris, France
APHP La pitié Salpêtrière - Anesthésie et soin intensif
RECRUITING

Paris, France
APHP Lariboisière
RECRUITING

Paris, France
CH Aurillac
NOT_YET_RECRUITING

Aurillac, France
CH Le puy en Velay
RECRUITING

Le Puy-en-Velay, France
CH Moulins-Yzeure
NOT_YET_RECRUITING

Moulins, France
CH Vichy
NOT_YET_RECRUITING

Vichy, France
CH de la Côte Basque
RECRUITING

Bayonne, France
CHRU Strasbourg - Service d'anesthésie-Réanimation médicale
RECRUITING

Strasbourg, France
CHU Bordeaux Hôpital Haut Lévèque
RECRUITING

Bordeaux, France
CHU Bordeaux Pellegrin Hospital
RECRUITING

Bordeaux, France
CHU Clermont-Ferrand Estaing
RECRUITING

Clermont-Ferrand, France
CHU Clermont-Ferrand Gabriel Montpied
RECRUITING

Clermont-Ferrand, France
CHU Dijon
RECRUITING

Dijon, France
CHU Grenoble
NOT_YET_RECRUITING

Grenoble, France
CHU Montpellier
RECRUITING

Montpellier, France
CHU Nantes
RECRUITING

Nantes, France
CHU Nîmes
NOT_YET_RECRUITING

Nîmes, France
CHU Poitiers
RECRUITING

Poitiers, France
CHU Rennes
RECRUITING

Rennes, France
CHU Strasbourg Service d'Anesthésie-Réanimation chirurgicale
RECRUITING

Strasbourg, France
CHU la pitié slapêtrière - Anesthésie Réanimation
RECRUITING

Paris, France
CHu Angers
NOT_YET_RECRUITING

Angers, France
Chu Toulouse
RECRUITING

Toulouse, France
HCL - Lyon Sud
NOT_YET_RECRUITING

Lyon, France
HCL Hôpital Edouard Herriot
NOT_YET_RECRUITING

Lyon, France

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