Could two steroids slash septic shock deaths?
NCT ID NCT07383103
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving two steroids—hydrocortisone and fludrocortisone—for up to 7 days can lower the risk of death in adults with septic shock. About 336 patients will be randomly assigned to receive either the steroid combo or standard care alone. The main goal is to see if the treatment reduces deaths within 90 days.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Hydrocortisone and fludrocortisone (steroid drugs)
- What this could lead to
- If it works, this could offer a simple, short-term drug combo to lower death rates in septic shock patients.
- What could go wrong
- This is a phase 4 trial, so the drugs are already approved, but septic shock is complex and previous steroid studies have had mixed results. Side effects like infections or gastrointestinal issues are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Northern Jiangsu People's Hospital
RECRUITINGYangzhou, Jiangsu, 225000, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Blood filter could shield vessels in septic shock