SEPTIC SHOCK

This small, early-stage study is testing if a gentle, non-invasive stimulation of a nerve in the ear can help calm the body's dangerous overreaction to a severe infection, known as septic shock. Researchers will compare the effects of real stimulation versus a sham (fake) stimula…

This is a small, early-stage study to see if draining lymph fluid from a chest duct is safe and can lower harmful inflammation in critically ill patients with septic shock. Up to 10 adult patients in a surgical ICU will have the fluid drained for up to 7 days. The main goal is to…

This study is testing whether using a specific blood measurement called the CO2 gap is better than the current standard (lactate level) for guiding early emergency treatment in patients with septic shock. It will involve 750 adult ICU patients with severe sepsis and low blood pre…

This study is testing a new program to help doctors in pediatric intensive care units (PICUs) use a powerful antibiotic called vancomycin more carefully. The goal is to reduce unnecessary prescriptions, which can cause kidney damage, while still effectively treating children with…

This large study aims to find the best timing for adding a second blood pressure drug (vasopressin) to standard treatment (norepinephrine) for patients with life-threatening septic shock in intensive care. It will compare starting vasopressin early versus only adding it later if …

This study aims to find out which of two common drugs, adrenaline or dopamine, works better to stabilize children with a severe, life-threatening condition called septic shock. It will involve 90 children aged 1 month to 12 years who are not responding to standard fluid treatment…

This study is testing whether adding a special immune-boosting drug called Pentaglobin to standard care helps patients with a severe abdominal infection called peritonitis. Researchers will enroll 200 very sick patients to see if the treatment reduces organ failure and death. A k…

This study aims to find the best way to treat new irregular heartbeats that develop in critically ill patients with septic shock. Researchers will compare three common approaches: controlling heart rate with medication, trying to restore normal rhythm with medication or electrica…

This study is a small, first-step trial to see if it's practical to run a larger study on methylene blue for septic shock. It aims to see if this old, safe drug can improve blood flow in the body's smallest vessels when given early. The study will enroll 50 adults with septic sho…

This large international trial is testing whether adding the steroid hydrocortisone to standard care helps children with life-threatening septic shock. It aims to see if the drug reduces new or worsening organ damage and improves the chances of survival without severe disability.…

This study is testing if using a simple finger sensor to guide fluid treatment can prevent severe skin breakdown in elderly, critically ill patients. Researchers are comparing this sensor-guided approach to standard care in 216 older ICU patients with severe infections or shock. …

This study is testing a computer alert system in hospital records to help doctors decide when to add a second blood pressure medication (vasopressin) for patients with severe septic shock. It will enroll 300 adults in a specific ICU to see if the system can create two groups: one…

This large study is testing whether carefully limiting the amount of non-emergency fluids given to adults with septic shock improves survival and reduces complications. It will compare a strict fluid-reduction plan against standard care in 1,850 critically ill patients. The goal …

This study is collecting real-world information on a treatment called ARTICE for people with severe sepsis or septic shock in the ICU. It aims to see how well the treatment works by tracking organ function, survival rates, and hospital stay length. The goal is to better understan…

This small pilot study is testing whether giving a medication called angiotensin II early in the emergency department is practical and helpful for patients with septic shock—a life-threatening condition where blood pressure drops dangerously low. The study will enroll 20 adults w…

This study aims to find the safest way to stop a medication called vasopressin in ICU patients recovering from septic shock. Researchers will compare slowly reducing the dose versus stopping it suddenly to see which method causes fewer dangerous drops in blood pressure. The goal …

This study is testing whether adding a second steroid (fludrocortisone) to the standard steroid (hydrocortisone) helps adults with life-threatening septic shock. It will compare the two-drug combination against standard care in 336 patients. The main goal is to see if the combina…

This study is comparing two ways to give fluids and medications to liver patients with severe, life-threatening infections (sepsis). One method uses a bedside heart ultrasound to carefully guide treatment, while the other follows a standard protocol. The goal is to see if the ult…

This study aims to find a better way to predict which patients with septic shock will benefit from receiving intravenous (IV) fluids. It will compare two non-invasive monitoring methods: one using ultrasound to look at a major vein and another using a sensor on the chest to measu…

This study aims to find new blood markers that can help doctors diagnose sepsis more quickly and accurately when patients arrive at the emergency room with suspected infections. Researchers will follow 3,300 patients to compare immune responses in those with and without sepsis, a…

This study aims to see if a protein in the blood called Vasn can help doctors better diagnose septic shock, a life-threatening infection complication. Researchers will compare Vasn levels in 144 ICU patients with septic shock to those with other types of shock. The goal is to fin…

This study aims to create a computer program (AI) that can scan a patient's routine hospital data to predict sepsis and septic shock earlier than current methods. Researchers will analyze the medical records of 10,000 adults who stayed in intensive care. The goal is to see if fas…

This study aims to understand how patients with septic shock respond to fluid treatment by measuring their body's oxygen use and chemical patterns. Researchers will observe 120 critically ill patients in intensive care units during their first 24 hours of treatment. The goal is t…

This study aims to better understand a severe and complex type of heart failure called mixed cardiogenic-vasoplegic shock. Researchers will look back at the medical records of 2,500 patients from three French hospitals to see how many survive and what factors lead to worse outcom…

This study aims to understand if a person's level of frailty before getting sick can predict their chances of survival and recovery from severe septic shock. Researchers will follow 200 adults aged 65 or younger who are admitted to intensive care with this life-threatening condit…

This study aims to find biological markers that can predict which sepsis patients will get much worse and develop septic shock. Researchers will compare blood samples from 25 male patients who have sepsis after major digestive cancer surgery. They are looking for differences betw…

This study aims to understand if adding specific nutrients to blood cells can fix their energy production in patients with septic shock, a severe infection causing organ failure. Researchers will take blood samples from 55 patients in intensive care and test the cells in a lab. T…

This study observes how doctors use the medication vasopressin in real-world hospital settings for patients with severe septic shock in the ICU. It aims to see if starting vasopressin earlier alongside standard treatment can improve survival and protect kidney function. The resea…

This study aims to compare two different software programs used to analyze heart scans in patients with septic shock, a life-threatening condition. Researchers will use existing heart scan images from 60 patients to see if the software programs give similar results and how consis…

This study aims to measure how much antibiotic medication is removed from the blood when ICU patients with severe septic shock and kidney failure are treated with a special blood-filtering machine. Researchers will enroll 20 adult patients to take blood samples before and after t…

This study aims to understand how long a special blood filter keeps working effectively in adults with septic shock, a life-threatening infection. Researchers will observe 29 patients in intensive care who are already receiving this filter as part of their standard treatment. By …

This study is creating a large international registry to collect real-world data on how a medical device called CytoSorb is used in critical care. The device filters harmful substances from a patient's blood and is used for various severe conditions like septic shock, severe trau…