SEPTIC SHOCK

This study tests whether adding a special blood-filtering cartridge (PMX) to usual hospital care can help people with septic shock caused by endotoxins. About 150 adults with severe low blood pressure needing strong medicines will be randomly assigned to get the filter plus stand…

This study tests a drug called ivabradine in 429 adults with septic shock, a life-threatening infection that causes dangerously fast heart rates. Unlike standard treatments, ivabradine lowers heart rate without weakening the heart's pumping ability or dropping blood pressure. The…

This study looks at the best time to add a second blood pressure medicine (vasopressin) for people with life-threatening low blood pressure from severe infection (septic shock). About 2,050 adults in hospital will be treated using either an early or later start of vasopressin. Th…

This study tests a blood purification therapy for critically ill adults with septic shock caused by a bloodstream infection. The treatment uses a device to filter harmful substances from the blood. Researchers want to see if it helps patients leave the ICU sooner and reduces side…

This study tests whether a new blood-cleaning method, called adaptive blood purification, can help people with septic shock survive longer. About 276 adults in the ICU will be randomly assigned to receive either standard care or this new treatment on top of standard care. The mai…

This study compares a drug called Angiotensin II to the usual treatment for raising blood pressure in people with liver disease who have a dangerous drop in blood pressure (shock). The goal is to see if Angiotensin II helps the heart and blood vessels work together better. About …

This study tests whether metformin, a common diabetes medicine, is safe and practical to use for treating acute kidney injury caused by sepsis. Researchers will enroll 80 intensive care patients to monitor side effects and see if the treatment can be given successfully. This is a…

This study looks at whether starting continuous kidney therapy (CRRT) early can help children with septic shock recover faster. Researchers will monitor 50 children in the ICU to see how their blood pressure, organ function, and inflammation levels change. The goal is to gather e…

This study looks at how sepsis affects the heart in intensive care patients. Researchers will monitor heart function, blood markers, and patient outcomes in about 330 adults with septic shock. The goal is to find better ways to diagnose and predict heart-related complications, no…

This study looks back at over 31,000 hospital records from Catalonia, Spain, to understand how often septic shock happens and how many people die from it. Researchers want to find differences between hospitals to improve care. The study does not test any new treatment, but gather…