SEPTIC SHOCK

This study looked at 60 adults with septic shock in the emergency department to see if using ultrasound or a noninvasive heart monitor (NICOM) helps doctors give fluids more effectively. Both groups also received standard sepsis care. The goal was to see which method improves blo…

This small pilot study looked at whether a procedure called therapeutic plasma exchange (TPE) is safe for adults with septic shock, a life-threatening infection that causes organ failure. Seventeen patients received TPE within 24 hours of diagnosis. The main goal was to check for…

This study tested whether a special donor plasma product (OctaplasLG) can help correct dangerous blood clotting problems in people with septic shock. The trial included 60 adults with septic shock and clotting issues. Researchers measured how quickly treatment was given and track…

This study tested a personalized approach to managing fluids in patients with septic shock, a life-threatening condition. The goal was to see if using mini-fluid challenges to tailor fluid balance could reduce organ failure compared to standard care. Over 500 adults in intensive …

This study tested a technique called remote ischemic conditioning in 180 adults with septic shock. The approach involves briefly inflating and deflating a blood pressure cuff on the arm to protect organs from damage. The goal was to see if this simple procedure could reduce the s…

This study tested whether a drug called GM-CSF can reduce new infections in ICU patients whose immune system is weakened after severe sepsis or septic shock. 166 adults were randomly given either GM-CSF or a placebo. The goal was to see if the drug could lower the number of hospi…

This pilot study tested whether adding methylene blue to usual care is feasible for adults in the intensive care unit with septic shock. Researchers enrolled 50 patients to check recruitment rates, consent rates, and how well doctors followed the treatment plan. The goal was to s…

This study tested whether a structured plan to remove extra fluids early can help patients with septic shock. 170 adults in the ICU were randomly assigned to either the fluid removal protocol or standard care. The goal was to see if the plan was feasible and reduced fluid overloa…

This study tested whether giving very high doses of vitamin C to people with sepsis (a severe infection that can cause organ failure) could lower the chance of dying within 28 days. 234 adults in intensive care received either vitamin C or a placebo for up to 4 days. The main goa…

This study tested whether giving a concentrated protein solution (albumin) along with standard fluids is possible in patients with septic shock. 47 adults with severe infection and low blood pressure were enrolled. The main goal was to see if enough people could be recruited to r…

This pilot study tested whether giving a sodium lactate solution to people with septic shock could help manage their fluid balance. Septic shock is a life-threatening condition where blood pressure drops dangerously due to infection. The study involved 59 participants and compare…

This study tested whether adding a medication called methylene blue to standard care helps adults with septic shock recover faster. Researchers randomly assigned 88 patients to receive either methylene blue or a placebo to see if it could reverse shock and improve survival. The m…

This small pilot study tested whether a gentle massage technique called manual lymphatic drainage is safe and practical for patients recovering from septic shock. The goal was to see if it could help reduce organ failure and improve recovery. The study included 24 adults in the i…

This study looked at how the heart's pumping and filling ability affects survival in people with septic shock, a severe infection that causes organ failure. Researchers studied 440 ICU patients to see if heart problems lead to fluid overload and higher death risk. The main goal w…

This study tested a handheld microscope to see tiny blood vessels in people with sepsis, a life-threatening infection. Researchers wanted to learn how blood flow problems relate to organ damage. 68 adults took part to help design better future treatments.

This study looked at 40 adults with septic shock (a severe infection causing very low blood pressure) to see if two blood markers, renin and DPP3, can predict who will respond better to a drug called angiotensin II versus standard blood-pressure-raising medicines. The goal was to…

This study looked at 80 adults with septic shock to see if a simple finger sensor (peripheral perfusion index) can accurately predict tissue health when different doses of the drug norepinephrine are used. The goal was to find out if the sensor's readings remain reliable regardle…

This study observed how doctors give fluids to nearly 5,000 critically ill patients in ICUs around the world. The goal was to understand current practices and see if the way fluids are given affects patient outcomes. No new treatments were tested; instead, researchers collected d…

This study looked at 196 adults with septic shock in intensive care to see if a blood test measuring immature platelets could predict their risk of death or organ failure at 28 days. The goal was to find a cheap, routine test to identify high-risk patients early. The study did no…

This study reviewed records of 1248 adults admitted to an intensive care unit (ICU) in 2025. Researchers wanted to see if the reason for admission (like sepsis or breathing failure) could predict who dies in the ICU, beyond what standard severity scores show. The goal is to impro…

This study looked at 52 ICU patients with septic shock to understand why they lose muscle mass. Researchers measured a protein called PTP1B and checked muscle size using ultrasound. They also tested blood levels of zonulin, a marker of gut health. The goal was to find links betwe…

This study looked at whether a blood-filtering device called Efferon LPS removes antibiotics from the blood of people with sepsis. Sepsis is a severe infection that can lead to organ failure, and blood filters are sometimes used to help clean the blood. The goal was to measure ho…

This study looked at how the immune system changes after serious events like septic shock, severe trauma, burns, or major surgery. The goal was to confirm that many patients enter a state of immune suppression, which raises the risk of dangerous secondary infections. Researchers …

This study looked at 145 people with septic shock who received a standard fluid infusion over 10 minutes. Researchers wanted to see if checking the response right after the infusion versus waiting 20 minutes changed whether patients were labeled as "responders." The goal was to u…

This study looked at 150 adults with sepsis to see if a score called EASIX (based on routine blood tests) could predict who would die or have serious complications within 28 days. Researchers tracked deaths, septic shock, and kidney injury. The goal was to find a simple tool to h…

This study looked at 103 adults with septic shock to see if a protein called VEGF-A is linked to how much fluid they retain. The goal was to better understand why patients with sepsis often develop fluid buildup, which can be harmful. Researchers measured VEGF-A levels and fluid …

This study looked at the fluid between cells (interstitial fluid) in 26 intensive care patients with septic shock or non-septic shock. The goal was to understand how this fluid changes during sepsis, which could explain why severe swelling occurs. Researchers measured components …

This study examined whether routinely using a portable ultrasound device (POCUS) in the ICU improves outcomes for patients with septic shock. Researchers compared data from 200 patients treated before and after POCUS was introduced, looking at organ failure scores and survival ra…

This study looked at 30 intensive care patients with septic shock to see how a high dose of the drug norepinephrine (used to raise blood pressure) affects the smallest blood vessels in the body. Researchers measured oxygen levels in muscle tissue to check microcirculation and com…

This study looked back at the records of 400 adults in intensive care with septic shock and acute kidney injury who needed dialysis. It compared those who used a special filter called Oxiris, which also removes toxins and inflammation, to those who used standard filters. The goal…

This study looked at 80 adults in the ICU with septic shock to see if raising blood pressure from 65 mmHg to 85 mmHg helps protect kidney function. Researchers used ultrasound to measure kidney blood flow and tracked changes in kidney injury stages. The goal was to find out if a …

This study looked at two blood markers—neutrophil CD64 and monocyte HLA-DR—in 76 people with septic shock, a life-threatening condition. Researchers measured these markers on day 1 and day 8 to see how the immune system changes over time. The goal was to learn whether these marke…

This study looked at how platelets (blood cells that help clotting) become activated in people with septic shock, a life-threatening infection that causes organ failure. Researchers measured specific markers on platelets and platelet-white blood cell clumps in the blood of 27 pat…

This study looked at 124 people with septic shock to see if the difference between carbon dioxide levels in veins and arteries could predict who would get worse. Researchers monitored patients closely for three days and tracked organ failure and survival at 28 days. The goal was …

This study looked at how the body processes antifungal drugs (echinocandins) in 24 adults with septic shock caused by a serious abdominal infection (peritonitis). The goal was to measure drug levels in the blood to help doctors give the right dose. It did not test a new treatment…

This study looked at whether giving less fluid (other than the fluids needed to treat shock) to ICU patients with septic shock could reduce dangerous fluid buildup. 50 patients were split into two groups: one got standard care, the other got a strict fluid-minimizing plan. The go…

This study looked at 60 adults with septic shock in the ICU to see if their intestines were leaking bacteria into the blood. Researchers measured specific DNA markers and gut health proteins over seven days. The goal was to better understand how gut problems might make septic sho…

This study looked at how COVID-19 causes organ failure in intensive care patients. Researchers tracked 380 adults with suspected or confirmed COVID-19 in the ICU, measuring kidney injury, breathing problems, and survival rates. The goal was to better understand the disease, not t…

This study looked at 945 adults with septic shock in the ICU to compare two ways of giving blood pressure medicines (vasopressors): one based on the patient's weight and one not. The goal was to see if one approach leads to better outcomes or fewer side effects. Researchers also …