SEPTIC SHOCK

This study tested a new approach to managing fluids in intensive care patients with septic shock. Researchers wanted to see if strictly limiting fluids given for routine maintenance and medication delivery, while still giving emergency resuscitation fluids, could improve a patien…

This study tested whether adding a low-cost, widely available drug called methylene blue to standard care could help adults with septic shock in the intensive care unit. It was a small pilot trial with 50 participants to see if a larger study would be possible. The goal was to se…

This study tested whether a simple procedure called remote ischemic conditioning could reduce organ failure in people with septic shock. Doctors used a blood pressure cuff on patients' arms to create brief, controlled periods of reduced blood flow, hoping this would trigger the b…

This study tested two different monitoring tools to help doctors give the right amount of fluids to patients with septic shock in the emergency room. Sixty patients were randomly assigned to have their fluid treatment guided by either a bedside ultrasound machine or a non-invasiv…

This study tested whether adding a medication called methylene blue helps adults with septic shock recover faster. Septic shock is a life-threatening condition where blood pressure drops dangerously low. Researchers gave methylene blue to some patients to see if it helped them ge…

This small, early-stage study tested whether a blood-filtering procedure called therapeutic plasma exchange (TPE) is safe for adults with severe septic shock, a life-threatening condition with high mortality. The main goal was to check for safety issues and determine a tolerable …

This study tested whether a special, standardized plasma product (OctaplasLG®) could help control dangerous blood clotting problems in patients with septic shock. It compared the plasma treatment to a saline placebo in 60 critically ill adults. The main goal was to see if it was …

This UK study tested whether a special fluid made from a blood protein (20% albumin) works better than standard salt solutions for patients with life-threatening septic shock in intensive care. The main goal was to see if it's practical to run a larger future trial. Researchers r…

This study tested whether a drug called GM-CSF could reduce secondary infections in ICU patients recovering from severe sepsis or septic shock. Researchers enrolled 166 patients whose immune systems were weakened by their initial infection. Half received GM-CSF injections and hal…

This pilot study tested whether infusing sodium lactate, compared to normal saline, could help better manage fluid levels in patients with septic shock. It involved 59 critically ill patients and measured how the treatment affected fluid balance, organ failure, and survival over …

This study investigated whether adjusting blood pressure targets could help protect kidney function in patients with septic shock, a life-threatening condition. Researchers tested if raising a patient's average blood pressure from a standard target to a higher one would improve a…

This study tested whether a personalized plan for giving fluids to patients with septic shock could reduce organ damage. Doctors compared a new method using small 'mini-challenges' of fluid to see how a patient's body responds, against the usual standard care. The goal was to fin…

This small, completed pilot study tested whether a gentle massage technique called manual lymphatic drainage is safe and practical for patients recovering from septic shock. The goal was to see if stimulating the body's fluid drainage system could help reduce swelling and improve…

This study aimed to understand how septic shock affects the gut. Researchers monitored 60 adult patients in intensive care to see if bacteria were leaking from their intestines into their bloodstream. They took blood and stool samples over seven days to measure markers of gut dam…

This study aimed to understand how COVID-19 causes organ damage in critically ill patients. Researchers followed 380 patients in intensive care with suspected or confirmed COVID-19, collecting daily blood, urine, and sputum samples. They analyzed these samples to identify biologi…

This study looked back at medical records to compare two different ways of giving blood pressure drugs to patients with septic shock, a severe infection. Researchers wanted to see if dosing based on a patient's weight leads to better or worse results than a standard fixed dose, e…

This study aimed to understand how different patterns of heart function affect survival in patients with septic shock, a severe blood infection. Researchers followed 440 intensive care patients, using daily heart ultrasound scans to measure how well the heart pumps and relaxes. T…

This study aimed to understand if high levels of a protein called VEGF-A, which can make blood vessels leaky, are linked to fluid buildup in patients with septic shock. Researchers measured VEGF-A levels and tracked fluid balance in 103 adults with this severe condition during th…

This study aimed to find better ways to predict how sepsis patients will fare. Researchers tested a new handheld microscope to measure tiny blood vessels and a blood marker related to blood vessel lining in 68 adults with sepsis. The goal was to see if these measurements could be…

This study aimed to see if measuring 'young' platelets in a routine blood test could help predict how sick a patient with severe sepsis might become. Researchers followed 196 adults admitted to intensive care with sepsis or septic shock. They checked if the level of these young p…

This study aimed to understand if the timing of checking a patient's response to intravenous fluids matters in septic shock. Researchers gave 145 critically ill patients a standard fluid dose and measured their heart's response immediately after and 20 minutes later. The goal was…

This study looked at how high doses of a common medication (norepinephrine) used to treat septic shock affect the body's smallest blood vessels. Researchers monitored 30 critically ill patients to see if changes in these tiny vessels were linked to survival after 28 days. The goa…

This study aimed to understand if a blood-filtering device used to treat severe sepsis also removes important antibiotics from a patient's bloodstream. Researchers observed 30 patients with sepsis to measure how much of three common antibiotics was filtered out by the device. The…

This study aimed to understand how severe medical events like septic shock, major trauma, burns, or surgery can weaken a patient's immune system. Researchers followed 552 adult patients and healthy volunteers, taking blood samples to measure immune function over time. The goal wa…

This study looked at whether a simple score calculated from routine blood tests (called EASIX) can predict which sepsis patients are most likely to die or develop serious complications. Researchers followed 150 adult patients in intensive care who had sepsis. The goal was to see …

This study aimed to understand why patients with severe sepsis or septic shock lose muscle mass, which is linked to worse outcomes. Researchers measured a specific protein (PTP1B) and a gut health marker (zonulin) in 52 patients to see if they were connected to muscle loss. The g…

This study aimed to understand how two antifungal drugs (caspofungin and micafungin) move through the bodies of critically ill patients. It involved 24 adults in intensive care with a severe abdominal infection (peritonitis) that led to septic shock. Researchers measured drug lev…

This study aimed to see if two specific markers in the blood could help doctors better understand and predict outcomes for patients with septic shock, a severe and life-threatening infection. Researchers measured these markers in 56 patients on their first and eighth day in the I…

This study aimed to see if a simple finger clip monitor (Peripheral Perfusion Index) could accurately measure blood flow to tissues in patients with septic shock, a life-threatening condition. Researchers tested this at different doses of a standard blood pressure medication (nor…

This small, completed pilot study tested whether two substances in the blood (renin and DPP3) can predict which patients with severe septic shock will respond better to a drug called angiotensin II versus standard vasopressor therapy. The goal was to gather information to design …

This study looked back at the records of 1,248 adult patients in an intensive care unit (ICU) to see if the type of illness they had when admitted (like sepsis or respiratory failure) was linked to their chance of dying in the ICU. Researchers wanted to know if these diagnoses pr…

This study aimed to understand how doctors around the world give fluids to critically ill patients in intensive care units (ICUs). It observed over 4,700 patients to see if the amount, type, and method of giving fluids are linked to how well patients recover, including survival a…

This study aimed to understand how tiny blood cells called platelets become overactive in people with septic shock, a life-threatening condition. Researchers compared blood samples from 27 patients in intensive care with septic shock to samples from people having routine knee or …

This small, completed study aimed to understand why dangerous fluid buildup happens in septic shock, a severe and often fatal infection. Researchers compared the makeup of a specific body fluid from 26 sedated patients—some with septic shock and some with other types of shock. Th…