Can a blood protein boost survival in septic shock?

NCT ID NCT07212582

Not yet recruiting Disease control Sponsor: Mahidol University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving extra human albumin—a natural blood protein—along with standard care can help people survive septic shock after surgery. Septic shock is a life-threatening condition where infection causes dangerously low blood pressure. The trial will enroll 304 adults in the surgical ICU, giving some patients albumin infusions for up to 3 days to keep their albumin levels high. The main goal is to see if more patients are alive at 28 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: human albumin (20% solution)
What this could lead to: If it works, this could point toward a simple, widely available treatment to improve survival in surgical septic shock.
What could go wrong: This is a single-center trial with 304 patients, so results may not apply everywhere. Previous studies on albumin in sepsis have had mixed results, so there is no guarantee of benefit.

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Conditions

The condition(s) this trial relates to.

Critical Illness toxic shock syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CRITICAL ILLNESS SEPTIC SHOCK

Contacts and locations

Locations

Faculty of Medicine, Siriraj Hospital, Mahidol University

Bangkok, Bangkoknoi, 10700, Thailand

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