Blood filters aim to reverse organ failure in septic shock

NCT ID NCT07661303

Not yet recruiting Disease control Sponsor: Moscow Multidisciplinary Clinical Center "Kommunarka" Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This study tests whether special blood purification devices can help people with septic shock, a life-threatening condition where infection causes organ failure. The trial includes adults aged 18 to 80 with severe septic shock. Depending on their level of endotoxins, patients receive either a device that targets bacterial toxins or one that removes general inflammatory substances. The goal is to see if these treatments improve organ function within 72 hours.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: blood purification devices (Efferon LPS, Toramyxin PMX 20R, Jafron HA 330, CytoSorb)
What this could lead to: If effective, these blood purification methods could offer a new way to reduce organ failure and improve survival in septic shock.
What could go wrong: This is a small pilot study, so results may not be definitive. The devices are compared against each other, not a placebo, and septic shock is complex with many variables.

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Conditions

The condition(s) this trial relates to.

Endotoxemia multiple organ dysfunction syndrome toxic shock syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEPTIC SHOCK

Contacts and locations

Locations

Bakulev Scientific Center of Cardiovascular Surgery

Moscow, Russia
City Clinical Hospital No 52, Moscow, Russia

Moscow, Russia
City clinical hospital named after S. S. Yudin, Moscow City Health

Moscow, Russia
Moscow Multi-disciplinary Clinical Center "Kommunarka"

Moscow, Russia
National Medical Research Centre for Oncology Rostov-on-Don

Rostov-on-Don, Russia
Petrovsky National Research Centre of Surgery

Moscow, Russia
Sklifosovsky Institute of Emergency Care

Moscow, Russia

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