Multiple organ dysfunction syndrome

This trial tests whether a special alert system called ICU Beacon can help doctors in intensive care units detect early signs of organ failure. The study includes about 1,962 adult ICU patients and compares units using the software plus standard care to those using standard care …

This study looks at whether a special blood filter called oXiris helps people with septic shock and kidney failure survive. Researchers will review medical records of 360 adults in the ICU who needed continuous blood filtering. They will compare those who got the oXiris filter wi…

This study tests a device called Efferon LPS that filters harmful substances from the blood during and after heart surgery. The goal is to see if it can reduce the risk of multiple organ failure, a serious complication. Researchers will enroll 60 adults having heart surgery with …

This study tests whether anakinra, a drug that blocks inflammation, can help children with sepsis who are experiencing multiple organ failure. The trial will involve 500 children in intensive care, comparing anakinra to a placebo. The goal is to see if the drug can reduce organ d…

This phase 3 trial tests a new solution called Custodiol-N for preserving donated kidneys, livers, and pancreases before transplant. About 362 recipients will be randomly assigned to receive organs stored in either Custodiol-N or the standard Custodiol solution. The goal is to se…

This study tests whether a nerve block (erector spinae plane block) can improve organ function in septic patients who also have acute gut injury. The block uses a numbing medicine (ropivacaine) delivered near the spine. Researchers will measure organ failure scores in 116 ICU adu…

This study is watching 5,000 adult ICU patients to understand why some develop more severe organ failure than others. Researchers will track patients' health and quality of life for a year. The goal is to find new clues that could one day lead to better treatments for critical il…

This study is testing whether a device that measures brain activity (called BIS) can help doctors classify how severe sepsis is in critically ill patients. Researchers will compare BIS readings with a standard blood test (procalcitonin) to see if the brain monitor can track worse…

This observational study looks at whether certain genetic elements, called transposable elements, can prematurely age the immune system in people with sepsis. Researchers will analyze blood samples from 116 ICU patients with sepsis to see if these elements are linked to higher de…

This study looks at whether adding certain nutrients to blood cells from people with septic shock can help restore the cells' energy-making machinery (mitochondria). Researchers will collect blood samples from 55 patients in the ICU and test these nutrients in the lab. The goal i…