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Multiple organ dysfunction syndrome
MONDO:0043726The development of potentially reversible physiologic derangement involving two or more organ systems not involved in the disorder that resulted in intensive care unit (ICU) admission, and arising in the wake of a potentially life-threatening physiologic insult.
Also known as: multiorgan failure, multiple organ dysfunction syndrome, multiple organ failure, multiple organ system failure, MODS, failure, multiple organ, multi-organ failure, multiple organ failures
45 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Blood filters aim to reverse organ failure in septic shock
Disease control Not yet recruitingThis study tests whether special blood purification devices can help people with septic shock, a life-threatening condition where infection causes organ failure. The trial includes adults aged 18 to 80 with severe septic shock. Depending on their level of endotoxins, patients rec…
Phase: NA • Sponsor: Moscow Multidisciplinary Clinical Center "Kommunarka" • Aim: Disease control
Last updated Jul 04, 2026 00:00 UTC
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Can a blood filter save lives in septic shock?
Disease control Not yet recruitingThis study tests a blood purification filter called Oxiris in adults with septic shock and organ failure. Researchers want to see if it lowers the risk of death or worsening organ function within 7 days. Participants will receive the filter treatment for up to 3 days in the ICU a…
Phase: NA • Sponsor: Pusan National University Yangsan Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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Could a simple drug shield organs after aortic tear surgery?
Disease control Not yet recruitingThis study tests whether a drug called sivelestat sodium can reduce organ damage in people who have emergency surgery for a torn aorta (type A aortic dissection). About 236 patients will receive either the drug or a placebo for 3 days after surgery. The main goal is to see if the…
Phase: PHASE4 • Sponsor: Shanghai Zhongshan Hospital • Aim: Disease control
Last updated Jun 26, 2026 14:02 UTC
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Scientists probe immune cell shifts in ICU patients to unlock sepsis secrets
Knowledge-focused Not yet recruitingThis study examines how a type of immune cell called gamma delta T cells adapt and function in critically ill patients, both with and without sepsis. Researchers will compare these cells in healthy people, non-septic ICU patients, and septic ICU patients. The goal is to understan…
Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology • Aim: Knowledge-focused
Last updated Jul 04, 2026 00:00 UTC
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Gut feeling could save lives: new score may improve ICU death predictions
Knowledge-focused Not yet recruitingThis study looks at whether adding a measure of gut function to a standard organ failure score can better predict which critically ill patients are at highest risk of dying. Researchers will follow 800 adults in Turkish ICUs, using only routine data—no extra tests or treatments. …
Sponsor: Ozkul Yilmaz Colak • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:38 UTC
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Can a computer model predict sepsis after severe burns?
Knowledge-focused Not yet recruitingThis study follows 40 adults with serious burn injuries to collect blood, tissue samples, and medical record data. Researchers will look for patterns that could help predict who will develop sepsis or other complications. The goal is to build a computer-based 'digital twin' model…
Sponsor: Henry M. Jackson Foundation for the Advancement of Military Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Burn patient data could help predict deadly infections
Knowledge-focused Not yet recruitingThis study follows 80 adults with serious burns to understand how their bodies respond to injury and treatment. Researchers collect blood and tissue samples and review medical records to find patterns that might predict sepsis and other complications. The goal is to build compute…
Sponsor: Henry M. Jackson Foundation for the Advancement of Military Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Can the Body's own 'Off Switch' for inflammation predict who survives severe infection?
Knowledge-focused Not yet recruitingThis study will follow 300 adults with severe infections in the ICU to see how levels of specialized pro-resolving mediators (SPMs)—natural molecules that help stop inflammation—change over time. Researchers will use blood samples already collected during routine care, so no extr…
Sponsor: Second Affiliated Hospital of Wenzhou Medical University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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AI doctor in the ICU: can ChatGPT-5 save lives?
Knowledge-focused Not yet recruitingThis study tests whether an AI model (ChatGPT-5) can help doctors make better decisions for critically ill patients in the intensive care unit (ICU). About 1000 adults admitted to the ICU will be randomly assigned to standard care or care where the AI provides diagnostic and trea…
Phase: PHASE1, PHASE2 • Sponsor: MetroWest Artificial Intelligence Research Workgroup • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC