Multiple organ dysfunction syndrome
MONDO:0043726The development of potentially reversible physiologic derangement involving two or more organ systems not involved in the disorder that resulted in intensive care unit (ICU) admission, and arising in the wake of a potentially life-threatening physiologic insult.
Also known as: multiorgan failure, multiple organ dysfunction syndrome, multiple organ failure, multiple organ system failure, MODS, failure, multiple organ, multi-organ failure, multiple organ failures
45 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
-
New strategy could reduce organ failure in critically ill kids on life support
Disease control OngoingThis study looks at whether giving red blood cell transfusions only when a child is bleeding or not getting enough oxygen (instead of using a fixed hemoglobin level) can reduce organ damage and improve brain development. It involves 228 children under 6 years old on ECMO life sup…
Phase: NA • Sponsor: Boston Children's Hospital • Aim: Disease control
Last updated Jul 04, 2026 00:00 UTC
-
Could a simple drug stop deadly organ failure after surgery?
Prevention OngoingThis study tests if a drug called dalargin can prevent serious organ problems like kidney injury, lung failure, or heart damage after major abdominal surgery. About 200 adults having high-risk surgery will get either dalargin or a placebo for 3 days. The goal is to see if dalargi…
Phase: PHASE3 • Sponsor: Botkin Hospital • Aim: Prevention
Last updated Jun 27, 2026 09:05 UTC
-
New device aims to solve feeding problems in ICU patients with organ failure
Symptom relief OngoingThis study tests whether a device called RELiZORB™ can help critically ill adults with multiple organ failure better tolerate tube feedings. The device breaks down fats in the feeding to make them easier to digest. Researchers will compare how well patients meet their nutrition g…
Phase: NA • Sponsor: Inova Health Care Services • Aim: Symptom relief
Last updated Jul 03, 2026 00:00 UTC
-
New sedative could be safer for frail patients during medical procedures
Symptom relief OngoingThis study compares remimazolam, a new ultra-short-acting sedative, to propofol in 200 patients aged 65 or older with serious health conditions. The goal is to see if remimazolam provides better heart and breathing stability during endoscopic procedures. Researchers will also mea…
Phase: PHASE4 • Sponsor: Iuliu Hatieganu University of Medicine and Pharmacy • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
-
AI could help heart surgery patients get the right Anti-Inflammatory drug
Knowledge-focused OngoingThis study is looking at whether an artificial intelligence tool can help doctors decide which heart surgery patients might benefit from a drug called ulinastatin. Ulinastatin is used to reduce inflammation after surgery, but it doesn't work for everyone. Researchers will analyze…
Sponsor: Beijing Anzhen Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:33 UTC
-
New test could forecast COVID-19 Patients' future health
Knowledge-focused OngoingThis study aims to create a test that predicts how hospitalized COVID-19 patients will fare in the short and long term (up to one year). Researchers will enroll 600 adults from hospitals and Veterans' facilities, using medical records and lab data to forecast risks like frailty, …
Sponsor: University of California, Los Angeles • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
-
Sepsis heart damage: new study aims to unravel mysteries
Knowledge-focused OngoingThis study looks at how sepsis, a severe infection, can cause heart problems in intensive care patients. Researchers will collect data, blood samples, and heart ultrasound images from 330 adults with septic shock. The goal is to find patterns that help doctors better diagnose and…
Sponsor: Linkoeping University • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:03 UTC
-
Can early blood filtering help kids with septic shock?
Knowledge-focused OngoingThis study looks at 50 children with septic shock who receive early continuous renal replacement therapy (CRRT), a type of blood filtering. Researchers want to see if early CRRT helps stabilize blood pressure, reduce organ damage, and improve recovery. The goal is to gather infor…
Sponsor: National Children's Hospital, Vietnam • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC