New strategy could reduce organ failure in critically ill kids on life support

NCT ID NCT05405426

Ongoing Disease control Sponsor: Boston Children's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This study looks at whether giving red blood cell transfusions only when a child is bleeding or not getting enough oxygen (instead of using a fixed hemoglobin level) can reduce organ damage and improve brain development. It involves 228 children under 6 years old on ECMO life support. The goal is to find a safer transfusion approach for these critically ill patients.

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Conditions

The condition(s) this trial relates to.

multiple organ dysfunction syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EXTRACORPOREAL MEMBRANE OXYGENATION ORGAN FAILURE, MULTIPLE RED BLOOD CELL TRANSFUSION

Contacts and locations

Locations

Arkansas Children's Hospital

Little Rock, Arkansas, 72202, United States
Boston Children's Hospital

Boston, Massachusetts, 02115, United States
Children's Health Dallas University of Texas Southwestern

Dallas, Texas, 75235, United States
Children's Healthcare of Atlanta

Atlanta, Georgia, 30322, United States
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Children's Hospital Los Angeles

Los Angeles, California, 90027, United States
Children's Hospital of Michigan

Detroit, Michigan, 48201, United States
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Inova Children's Hospital

Falls Church, Virginia, 22042, United States
Lucile Packard Children's Hospital

Palo Alto, California, 94304, United States
Lurie Children's Hospital

Chicago, Illinois, 60611, United States
MUSC Shawn Jenkins Children's Hospital

Charleston, South Carolina, 29425, United States
Monroe Carell Jr. Children's Hospital at Vanderbilt

Nashville, Tennessee, 37232, United States
Phoenix Children's Hospital

Phoenix, Arizona, 85016, United States
Primary Children's Hospital

Salt Lake City, Utah, 84132, United States
Riley Children's Hospital

Indianapolis, Indiana, 46202, United States
Seattle Children's Hospital

Seattle, Washington, 98105, United States
Texas Children's Hospital - Baylor College of Medicine

Houston, Texas, 77030, United States
The Children's Hospital at Westmead

Westmead, New South Wales, Australia
The Hospital for Sick Children

Toronto, Ontario, M5G 1X8, Canada
University of Michigan Medical Center

Ann Arbor, Michigan, 48109, United States

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