Tailored breathing support may reduce lung injury in ECMO patients
NCT ID NCT07673250
First seen Jun 29, 2026 · Last updated Aug 07, 2026 · Updated 3 times
Summary
This study tests whether personalized ventilator settings can reduce lung injury in adults with severe respiratory failure who are on ECMO (a heart-lung machine). Researchers will use esophageal manometry or electrical impedance tomography to tailor the ventilator's positive pressure, compared to standard care. The goal is to see if this personalized approach lowers inflammation and improves lung mechanics.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Personalized Positive End-Expiratory Pressure (PEEP) via esophageal manometry or electrical impedance tomography
- What this could lead to
- If successful, this approach could reduce lung injury and speed recovery for patients with severe respiratory failure on ECMO.
- What could go wrong
- This is a small, early-stage study (62 participants) focused on biomarkers and mechanics, not yet proven to improve survival or long-term outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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UC San Diego Health Jacobs Medical Center
La Jolla, California, 92037, United States
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