Viral infectious disease

This study tests a collaborative care model where pharmacists, doctors, and patient navigators work together to provide hepatitis C treatment to people who use drugs and live in supportive housing. 444 participants will be randomly assigned to either this model or usual care. The…

This study tests a new two-drug combination (ASC22 and Peg-IFNa) to see if it can functionally cure chronic hepatitis B. About 150 adults with low virus levels will receive the treatment. The goal is to raise the cure rate above 50% without needing lifelong medication.

This study tests an experimental flu vaccine called BPL-1357, given as a shot or nasal spray, to see if it is safe and can protect against multiple flu types. About 129 healthy adults aged 18-55 will receive the vaccine or a placebo, then be exposed to a flu virus in a controlled…

This early-stage trial tests a vaccine called OSU-2131, designed to help the immune system fight Epstein-Barr virus (EBV). EBV can cause cancers in people who have weakened immune systems, such as those awaiting organ transplants. The study includes healthy volunteers and transpl…

This phase 1 trial tests a DNA vaccine designed to target HPV16, a virus that can cause high-grade cervical lesions (CIN2/3). The vaccine is given by injection into the muscle followed by a mild electrical pulse to help cells take up the DNA. The study includes both HIV-negative …

This phase 2 trial tests a CMV vaccine (CMV-MVA Triplex) given before a liver transplant to see if it reduces the need for antiviral drugs after surgery. The study enrolls 416 CMV-negative adults awaiting a liver transplant from a CMV-positive donor. Participants receive two vacc…

This early-stage trial tests a new vaccine called WGc0201 in 9 adults with chronic hepatitis B who are already on standard antiviral therapy. The vaccine is designed to boost the immune system to clear the virus, potentially leading to a functional cure. The main goal is to check…

This early-stage study is testing a new mRNA vaccine that aims to protect against both seasonal flu and COVID-19 with a single shot. Around 1,475 healthy adults aged 65 to 85 will receive either the new combo vaccine, a standard flu vaccine, or a licensed COVID-19 vaccine. Resear…

This study tests a dengue vaccine (TDV) in children aged 6 to 21 months. The goal is to see if the vaccine is safe and triggers a strong immune response. Participants receive two shots three months apart and are monitored for side effects and antibody levels.

This study tests a new vaccine to prevent chikungunya, a virus that causes fever and severe joint pain. About 6,144 people aged 12 and older will receive either the vaccine or a placebo. Researchers will check if the vaccine safely prevents infection and reduces long-term joint p…

This early-stage trial is testing a new COVID-19 booster vaccine called OCU500, which is given as a nasal spray or inhaled mist instead of a shot. The study involves 80 healthy adults aged 18-64 who have already been vaccinated against COVID-19. Researchers are checking if the va…

This Phase 1 trial tests a new type of COVID-19 vaccine made from artificial antigen presenting cells (aAPC). The vaccine is designed to teach the body's T cells to recognize and attack the SARS-CoV-2 virus. The study includes healthy volunteers and people with mild COVID-19, and…

This study tests a new dengue vaccine called V181 in 12,000 healthy children aged 2 to 17. The goal is to see if the vaccine is safe, triggers a strong immune response, and reduces cases of dengue fever caused by any of the four dengue virus types. Participants will receive eithe…

This trial is testing whether three different batches of a 9-valent HPV vaccine produce similar immune responses in 720 women aged 18-30 in China. Participants will receive three doses over six months, and researchers will measure antibody levels one month after the final dose. T…

This trial tests a new vaccine called LV-SMENP, designed to teach the body's immune cells to recognize and attack the COVID-19 virus. The vaccine uses a harmless virus to deliver pieces of the coronavirus into dendritic cells, which then activate T cells to fight infection. The s…

This early-stage study tests a new vaccine designed to prevent Sudan virus disease, a severe illness similar to Ebola. About 112 healthy adults aged 18-50 will receive either the vaccine or a placebo to check for side effects and measure immune responses. The goal is to see if th…

This study tests a new COVID-19 vaccine called VYD2311, given alone or together with an existing mRNA COVID-19 vaccine, in healthy adults aged 18 to 49. The goal is to check safety and measure the body's virus-fighting antibody levels. Participants receive one injection and are m…

This early-stage trial tests two experimental mRNA vaccines designed to train the immune system to make special antibodies that could block HIV. The study involves 40 healthy adults without HIV who will receive the vaccines and be monitored for safety and immune responses. It is …

This study is testing a new vaccine called JT118 to see if it is safe and triggers an immune response against monkeypox. About 180 healthy adults aged 18 to 59 will receive either the vaccine or a placebo. Researchers will monitor for side effects and measure immune responses ove…

This study tests the Shingrix vaccine in people with HIV and healthy volunteers to see how well it boosts immunity against shingles. Participants receive two shots two months apart and are followed for a year. The goal is to understand if the vaccine works safely in those with di…

This early-stage trial is testing a new HIV vaccine booster called VRIPRO, given with an immune-boosting adjuvant, in 40 healthy adults aged 18-60 who previously received an HIV vaccine in the HVTN 706 study. Participants will get three shots over 24 weeks. The main goals are to …

This early-stage study tests a new flu vaccine (STEMos1) in 56 healthy adults aged 18-50. Half of the participants get the vaccine with an adjuvant (a substance that boosts the immune response), and half get it without. The goal is to check safety and how well the vaccine trigger…

This study tests a new nasal spray vaccine (BLB-201) to prevent RSV, a common virus that can cause serious breathing problems in young children. About 137 infants and children aged 8 to 59 months will receive either the vaccine or a placebo. The goal is to check if the vaccine is…

This early-stage study is testing two new vaccines (V350A and V350B) designed to prevent diseases caused by the Epstein-Barr virus (EBV), which can cause infectious mononucleosis and is linked to certain cancers and multiple sclerosis. The study will enroll 250 healthy adults and…

This study tests an RSV vaccine in adults aged 18-59 who have health conditions like chronic lung, heart, or kidney disease that put them at higher risk for severe RSV. The goal is to see if the vaccine triggers a strong immune response and is safe. Participants receive one shot …

This study tests a new chickenpox vaccine in 600 healthy toddlers aged 12-15 months. The children receive two doses, and the new vaccine is compared to the current standard, Varivax. The goal is to see if the new vaccine produces a strong immune response and is safe.

This study tests a new chickenpox vaccine in 750 healthy children aged 12-15 months. Researchers will compare its safety to the existing Varivax vaccine. The goal is to see if the new vaccine causes similar side effects like injection site pain, fever, or rash.

This study tests a new chickenpox vaccine given as a muscle injection in healthy children aged 12 to 15 months. It compares the immune response and safety of this vaccine to the standard shot given under the skin. The study also looks at combining it with the MMR vaccine. About 9…

This study tests a new chickenpox vaccine in healthy children aged 12 to 15 months who have never had chickenpox or the vaccine. Researchers want to see if the new vaccine works as well as the approved Varivax vaccine and if different batches of the new vaccine produce consistent…

This study tests a single dose of an experimental RSV vaccine in Chinese adults aged 18 to 59 who have health conditions that raise their risk for severe RSV disease. Researchers will compare their immune response to that of older adults (60+) from a previous study. The trial als…

This study tests a new vaccine against respiratory syncytial virus (RSV) in adults. Phase I includes adults 18 and older to check safety of different doses. Phase II focuses on adults 60 and older to see how well the vaccine triggers an immune response and how safe it is. The vac…

This study tests an updated COVID-19 vaccine (mRNA-1283) designed to protect against current virus variants. About 832 people aged 12 and older, especially those at higher risk, will receive the vaccine. Researchers will measure immune response and monitor for side effects to ens…

This large study tests an RSV vaccine given to pregnant women to see if it safely protects their babies from severe RSV infection in the first months of life. About 13,000 pregnant women in Africa will receive either the vaccine or a placebo. The study also closely monitors wheth…

This study tests two experimental vaccines against Epstein-Barr virus (EBV), which causes mono and is linked to cancers. Researchers will give 750 healthy adults aged 18-29 three shots over several months to check for side effects and immune response. The goal is to find a safe v…

This study tests a bivalent HPV vaccine in healthy infants (9 months), toddlers (15 months), children (2-5 years), and unmarried young women (15-20 years) in Ghana. Researchers want to see if the vaccine is safe and triggers a strong immune response, especially when given alongsi…

This study tests a new vaccine called GBP511, designed to protect against several sarbecoviruses (a group that includes SARS-CoV-2). About 368 healthy adults will receive one or two doses at different strengths, with or without an adjuvant to boost immune response. The goal is to…

This study tests a new oral polio vaccine (nOPV3) in healthy young children, infants, and newborns in Panama. The goal is to see if it is safe and triggers a strong immune response compared to the current vaccine. About 1,500 participants will receive either the new or existing v…

This early-stage trial is testing several new vaccine formulas against RSV and H5N1 bird flu in 570 healthy adults aged 18 to 49. The main goals are to check safety and see how well the vaccines trigger an immune response. Participants will receive one or two shots and be followe…

This study tests a new seasonal flu vaccine that includes an adjuvant (ZFA02) to potentially boost the immune response. The trial involves 620 adults aged 18 and older, split into low-dose and high-dose groups, with some receiving a placebo. Researchers will monitor side effects …

This Phase 3 trial tests a new yellow fever vaccine (vYF) in about 2,440 healthy children aged 9 months to 5 years. Researchers will compare vYF to two licensed vaccines (Stamaril and YF-VAX) to see if it triggers a strong immune response and is safe. Some children will also rece…

This Pfizer study tests several experimental mRNA-based flu vaccines in 770 healthy adults aged 18 and older. Participants receive one dose and are monitored for about 6 months for safety and immune response. The goal is to see if these new vaccines are safe and trigger a strong …

This phase 2 trial tests a DNA vaccine called PVX4 in 138 women with HPV16-related high-grade cervical dysplasia (CIN2/3). The vaccine is given as a shot with a small electrical pulse to help it enter cells. The goal is to see if it can clear the virus and make abnormal cervical …

This study tests a stem cell transplant to control peripheral T-cell lymphoma in people whose cancer has not responded to standard treatments. Participants receive a donor's stem cells after chemotherapy or antibody therapy to prepare their body. The goal is to see if this approa…

This early-phase study tests whether Mozobil, a drug already used to boost stem cells for transplants, can safely raise white blood cell counts in people with WHIMS. WHIMS is a rare genetic condition that traps infection-fighting cells in the bone marrow, leading to frequent infe…

This early-stage study tests a new drug called IB-001 for chronic hepatitis B. It will first check safety in up to 60 healthy volunteers, then test multiple doses in about 30 people with chronic hepatitis B. The main goal is to see if the drug is safe and how the body handles it.

This phase 2 trial tests whether the drug nivolumab can slow or stop the growth of Epstein-Barr virus (EBV)-positive lymphoproliferative disorders and non-Hodgkin lymphomas. About 40 people aged 12 and older whose cancers have not responded to standard therapy will receive nivolu…

This study tests a program called Mentor Moms+ for pregnant women in South Africa who drink alcohol. Trained mentor mothers—women who have successfully reduced alcohol use while on HIV medication—provide one-on-one counseling sessions. The goal is to see if this approach helps wo…

This early-phase study tests two cancer drugs—lenvatinib (a daily pill) and pembrolizumab (an IV infusion)—in 20 adults with HPV-related recurrent respiratory papillomatosis (RRP) that has spread to the lungs. The goal is to see if the combination can shrink papillomas and reduce…

This study tests whether a combination of three drugs (cyclophosphamide, bortezomib, and maraviroc) can safely prevent graft-versus-host disease after a half-matched bone marrow transplant in people living with HIV who also have a blood cancer. The trial involves 265 participants…

This phase 3 trial tests a new antiviral pill, ibuzatrelvir, alone or with an IV drug (remdesivir) in 300 adults with weak immune systems who have mild-to-moderate COVID-19. The goal is to see if the combination prevents hospitalizations or worsening symptoms better than remdesiv…

This trial tests whether a two-drug combination (darunavir/cobicistat plus lamivudine) works as well as a standard three-drug combination (darunavir/cobicistat plus tenofovir alafenamide/emtricitabine) in people with HIV whose virus is already suppressed. The study involves 78 ad…

This phase 2 trial tests a DNA vaccine called pBI-11 in 48 women with persistent HPV16 or HPV18 cervical infection. The vaccine is designed to boost the immune system to clear the virus. Participants receive the vaccine or a placebo via injection with a special device. The study …

This phase 3 trial tests whether an inhaled solution of human interferon α1b can safely help children under 2 years old recover from respiratory syncytial virus (RSV) lower respiratory tract infections. The study compares the interferon treatment to a placebo, measuring improveme…

This study is testing the safety and drug levels of glecaprevir/pibrentasvir, a hepatitis C treatment, in 30 pregnant women with or without HIV. The goal is to see how the drug works during pregnancy and to monitor the health of both mothers and their infants up to 10 weeks after…

This study tests whether giving a second dose of an RSV vaccine to pregnant women who already received it in a prior pregnancy is safe and boosts immunity. About 550 women aged 18-49, between 24-36 weeks pregnant, will receive either the vaccine or a placebo. Researchers will tra…

This study tests a program to help women living with HIV in Ghana get screened for cervical cancer more easily. The program includes self-sampling kits, patient navigators, and training for healthcare providers. Researchers want to see if these tools increase screening rates and …

This study tests an oral medication called ibuzatrelvir in adults and teens with COVID-19 who are not hospitalized but have a high risk of becoming severely ill. Participants will receive either the drug or a placebo for 5 days, and researchers will track whether it reduces emerg…

This study tests a new treatment called LB-DTK-CMV for people with cytomegalovirus (CMV) retinitis that has not responded to standard antiviral medicines. The treatment uses a patient's own immune cells, specially trained to attack CMV, and is given as two infusions. The trial ai…

This study is for people with HPV-related throat cancer who have surgery to remove the tumor. Normally, some patients also get radiation afterward to lower the risk of cancer coming back. This trial tests whether it's safe to skip that radiation if a blood test two weeks after su…

This study tests a drug called felzartamab in people who received a kidney transplant and later developed microvascular inflammation (MVI), a type of injury to small blood vessels in the new kidney that can lead to serious problems. The trial includes 81 participants who will rec…

This study tests whether a non-invasive physical plasma treatment can clear HPV infections from the cervix. About 50 adults with HPV will receive the treatment, and researchers will check if the virus is gone afterward. The goal is to find a new way to prevent cervical cancer cau…

This study tests a new long-acting injectable drug called VH4524184 in healthy adults to see if it is safe and how the body handles it. The goal is to find a dose that could one day help control HIV with fewer shots. About 268 volunteers will receive either the drug or a placebo …

This study looks at a newly recognized disease called KSHV Inflammatory Cytokine Syndrome (KICS), caused by a virus that can also lead to certain cancers. Researchers aim to learn more about the disease and test experimental treatments, including antiviral and chemotherapy drugs,…

This early-stage trial tests whether adding the drug pomalidomide to standard chemotherapy (with or without rituximab) is safe and effective for people with HIV who have aggressive B-cell non-Hodgkin lymphoma. About 25 adults with high-risk features will receive up to 6 cycles of…

This trial tests whether giving the antiviral drug tenofovir disoproxil fumarate (TDF) to pregnant women with active hepatitis B can prevent the virus from spreading to their babies. The women take TDF from the 28th week of pregnancy until six weeks after giving birth, and all ne…

This study tests whether community health workers (CHWs) can help Black people with poorly controlled HIV achieve long-term viral suppression. CHWs provide support through weekly phone calls, home visits, and clinic accompaniment for three months. The study enrolls 10 Black adult…

This study tests whether adding the drug lenacapavir to standard HIV treatment can reduce the hidden HIV reservoirs that remain in the body. About 50 adults with well-controlled HIV will either continue their usual therapy or receive lenacapavir injections plus pills. Researchers…

This study tests whether switching from the current drug bulevirtide to a new drug called brelovitug can better control chronic hepatitis Delta. About 120 adults who have been on bulevirtide for at least 6 months will take brelovitug for 24 weeks. The main goal is to see if the v…

This study tests a program that sends personalized text messages and provides nicotine patches to help people with HIV in Cambodia stop smoking. Researchers will enroll 800 smokers and check if they quit after 6 months using self-reports and breath tests. The goal is to find a pr…

This study tests whether a combination of a special diet, omega-3 and L-carnitine supplements, and resistance exercise can improve muscle quality and reduce fat in veterans with HIV and obesity. The trial will enroll 70 participants and measure changes in muscle density, metaboli…

This study tests whether the antiviral drug molnupiravir can prevent severe illness from COVID-19 in adults at high risk. About 3,000 non-hospitalized participants will take either molnupiravir or a placebo for 5 days. The main goal is to see if the drug reduces hospitalizations,…

This early-phase trial tests a treatment called LB-DTK-MV, which uses immune cells from a healthy donor to fight three viruses (CMV, BKV, and EBV) that have become resistant to standard antiviral drugs. The study includes 27 adults who have had a stem cell transplant or certain c…

This early-phase trial tests a new type of immune cell therapy for patients with EBV-positive Hodgkin or non-Hodgkin lymphoma that has returned or not responded to standard treatments. The researchers add a gene called C7R to the patient's own T cells to help them survive longer …

This study tests whether giving patients special donor immune cells (called CD45RA-depleted DLI) can treat viral infections that persist after a stem cell transplant. The trial involves 30 participants who have not improved with standard antiviral drugs. Researchers will measure …

This study tests an experimental drug called DAS181 in people with weakened immune systems who have a serious lung infection caused by parainfluenza virus. The goal is to see if the drug helps them breathe without extra oxygen and reduces the risk of death. About 274 participants…

This study compares two patient navigation models for people recently involved in the criminal legal system who have substance use disorders. One group gets standard navigation, while the other can choose from a menu of services like in-person clinics, mobile health units, or tel…

This early-phase trial is testing an oral drug called VK-2019 in 30 adults with a type of lymphoma (DLBCL) that is linked to the Epstein-Barr virus and has not responded to at least two prior treatments. Participants take the drug daily in 28-day cycles at one of three dose level…

This trial tests whether infusing HPV-specific immune cells (HPV-CTLs) can safely reduce or clear HPV infection in people who haven't responded to standard treatments. Up to 100 participants will receive 2 to 4 infusions of these cells. The study measures safety and viral load ch…

This early-stage study tests whether a single dose of an experimental drug called IAP086 is safe in 30 adults with HIV whose virus is already well-controlled by standard antiretroviral therapy. Participants receive one intravenous infusion and are monitored closely for 28 days. T…

This early-stage trial tests a new gene therapy for certain T-cell lymphomas that have come back or not responded to treatment. The therapy uses a patient's own white blood cells, modified to attack cancer cells that carry a protein called CCR4. Up to 60 adults will receive the m…

This study tests an experimental antiviral drug called S-337395 in adults with RSV who are at high risk for severe illness. Participants must have symptoms for less than 72 hours and a confirmed RSV infection. The goal is to see if the drug can lower the amount of virus in the bo…

This early-stage trial is testing an experimental drug called GIGA-2339 in 48 adults with chronic hepatitis B. The main goal is to check if the drug is safe and how the body processes it. Participants will receive either GIGA-2339 or a placebo by IV infusion, and researchers will…

This study tests a 5-session virtual program called MATTER for 256 people living with HIV and substance use disorders in Boston and Miami. The program uses text messages and coaching to help people manage shame and stigma, set health goals, and stay connected to HIV care. The goa…

This trial investigates whether specially grown immune cells, called pathogen-specific cytotoxic T lymphocytes (CTLs), can safely and effectively treat stubborn infections like EBV, CMV, and adenovirus in people with weakened immune systems, such as stem cell or organ transplant …

This study tests whether teriflunomide, a drug already used for multiple sclerosis, can help people with a rare spinal cord disease called HAM/TSP caused by the HTLV-1 virus. About 24 adults will take the drug daily for 9 months to see if it reduces harmful immune activity and im…

This large platform trial is testing new antifungal drug combinations for cryptococcal meningitis, a severe brain infection that is fatal without treatment and common in people with HIV. The study will enroll 2,000 participants across multiple sites to compare a newer oral drug, …

This study follows 200 people with HIV who need a kidney transplant. Half will receive a kidney from a donor with HIV, half from a donor without HIV. Researchers track how many patients experience organ rejection or death over time to see if donor HIV status affects outcomes.

This early-stage study tests a new antibody called BNT351 in 67 adults, both with and without HIV. The goal is to check safety, how long the antibody stays in the blood, and whether it can lower HIV levels in people with the virus. It is a first step toward possibly controlling H…

This study tests an oral antiviral called ziresovir (AK0529) in adults at high risk for severe RSV infection, such as those with chronic lung or heart disease, weakened immune systems, or age 65 and older. Participants receive either the drug or a placebo, and researchers measure…

This study investigates whether a mobile app called reSET can help men who have sex with men, are living with HIV, and have a stimulant use disorder reduce their drug use and keep their HIV under control. Participants use the app for 12 weeks, completing modules on topics like ma…

This study tests whether a simple text-message system can help caregivers in Kenya spot and prevent malnutrition in children exposed to HIV. About 776 caregiver-child pairs will be split into two groups: one gets weekly SMS reminders to measure the child's arm and receive feeding…

This study looks at whether people with a type of throat cancer linked to the Epstein-Barr virus can safely receive lower doses of radiation after initial chemotherapy. The goal is to see if reducing radiation can still control the cancer while causing fewer long-term side effect…

This study tests a behavioral program for sexually active young people aged 16-24 who use stimulants like meth, cocaine, or MDMA. The goal is to help them reduce stimulant use and lower the risk of passing or getting HIV. Participants will receive counseling and support through v…

This study tests whether giving very early and intensive antiretroviral therapy, plus an antibody, can help infants with HIV achieve remission—meaning the virus stays undetectable even after stopping treatment. Researchers will enroll about 1,120 infants and follow them for safet…

This study tests whether adding the HIV drug rilpivirine to standard treatment can help people with HIV whose immune systems haven't fully recovered. About 21 adults with low CD4 counts despite years of successful viral suppression will receive rilpivirine for 48 weeks. The goal …

This phase 3 trial compares a new drug, brelovitug, to an existing treatment (bulevirtide) for chronic hepatitis delta, a serious liver infection. About 172 adults with the infection will receive either drug to see which better controls the virus and normalizes liver enzymes. The…

This study tests a short counseling program (about 4 sessions) designed to help pregnant and postpartum women in Cape Town, South Africa, keep taking their daily HIV-prevention pill (PrEP). Many women stop PrEP due to depression or trauma from violence. The program uses cognitive…

This study tests a device called DaRT that delivers a unique type of radiation (alpha particles) directly into tumors. It is designed for people with certain skin cancers, mouth cancers, or soft tissue sarcomas that are accessible for direct injection. The goal is to see if this …

This study tests a new biologic drug called HH-006 in 45 adults with chronic hepatitis B. Participants receive injections for 48 weeks, and researchers track how well the drug lowers hepatitis B surface antigen (HBsAg) levels. The goal is to see if the drug can control the infect…

This study looks at whether stem cell transplant patients can safely stop taking a medicine called letermovir earlier if their immune system shows a strong response to CMV. About 105 participants will be monitored to see if this approach reduces infections and side effects compar…

This early-stage trial tests a new therapy called CRMA-1001, which uses epigenetic gene silencing to turn off the hepatitis B virus in the body. About 66 adults with chronic hepatitis B who are already on antiviral pills will receive one or more IV infusions of the therapy. The m…

This study tests a mobile app called DynamiCare, combined with a patient navigator, to help people recently released from jail or prison reduce their use of stimulants like methamphetamine or cocaine. The app uses at-home saliva tests and financial rewards to encourage healthy be…

This study is testing whether the steroid dexamethasone can help people with severe dengue. The researchers will give either dexamethasone or a placebo to 200 infected adults in Thailand. They want to see if the drug lowers the death rate and shortens hospital stays.

This early-stage trial is testing whether lab-made antibodies that target HIV are safe and how long they stay in the body. About 83 healthy adults without HIV will receive the antibodies by vein or under the skin, alone or in combination. The goal is to find the right dose and ch…

This study offers continued access to HIV medications for children and adolescents who completed a previous Gilead HIV treatment study. About 350 participants will receive their study drug or switch to a standard HIV medication, and researchers will monitor for side effects. The …

This early-phase study tests whether specially trained immune cells from healthy donors can safely treat viral infections (EBV, CMV, adenovirus, BK virus) in patients who have had a stem cell transplant or certain CAR-T therapy. These infections can be life-threatening when the i…

This study tests whether a daily pill called AP1189 can help hospitalized patients with breathing failure due to viruses like flu, RSV, or COVID-19. About 96 adults will receive either AP1189 or a placebo for 14 days, on top of usual care. The main goal is to see if the drug redu…

This study tests whether the drug letermovir can prevent cytomegalovirus (CMV) from coming back in kidney or kidney/pancreas transplant patients who are at high risk. About 90 adults will take letermovir daily for 84 days and be followed for 6 months. The goal is to see if it red…

This study tests whether specially grown donor immune cells (called cytotoxic T lymphocytes) can safely and effectively control BK and JC virus infections in people with weakened immune systems, such as those with cancer, HIV, or organ transplants. About 100 participants will rec…

This study is testing the drug letermovir to prevent cytomegalovirus (CMV) infection in children and teens who have had a kidney transplant and weigh less than 40 kg. About 40 participants will receive the drug to see how it moves through their bodies and if it is safe. The goal …

This Phase 3 trial is testing a new drug called libevitug in 160 people with chronic hepatitis D, a serious liver infection. The goal is to see if libevitug can lower the virus in the blood and improve liver health. Participants receive the drug by IV infusion, and the study comp…

This early-stage trial tests whether specially grown immune cells from a donor can safely help transplant patients fight off viral infections that standard treatments can't control. The cells target Epstein-Barr virus, cytomegalovirus, adenovirus, and BK virus. Up to 36 adults wh…

This phase 2 trial tests whether adding an experimental vaccine (PRGN-2009) to standard chemotherapy can improve outcomes for people with newly diagnosed HPV-related throat cancer, potentially allowing them to skip radiation. About 70 adults will receive either chemo alone or che…

This study tests a therapeutic vaccine called TherVacB in 81 adults with chronic hepatitis B who are already on antiviral medication. The vaccine is given as a series of shots to boost the immune system and lower hepatitis B virus levels. The main goals are to check safety and se…

This early-stage trial tests a new drug called PRS CK STORM, made from a mix of immune and fat cells, to see if it can safely calm the 'cytokine storm'—a dangerous overreaction of the immune system—in people with severe lung infections from COVID-19, flu, or RSV. The study will e…

This phase 2 trial is testing whether combining two chemotherapy drugs—Abraxane and liposomal doxorubicin—can shrink tumors in people with advanced or unresectable angiosarcoma, a rare and aggressive cancer of blood vessels. The study will enroll 69 patients who have already trie…

This study tests whether a special T-cell vaccine, combined with an immune-boosting drug (vesatolimod) and two powerful antibodies, can help people with HIV control the virus without needing daily antiretroviral therapy. The trial involves 36 adults who started HIV treatment soon…

This study tests a new drug called GS-4321 for chronic hepatitis delta, a serious liver infection. First, healthy volunteers will help determine safe dosing. Then, people with the disease will receive multiple doses to see if the drug can reduce virus levels and improve liver hea…

This study looks at how well a long-acting injectable HIV treatment works in people with HIV-1 subtype A6, a common type in Eastern Europe. Researchers will compare medical records from 250 adults in Poland, Germany, and the Czech Republic who have already received the shots. The…

This study looks at whether starting hepatitis C treatment during pregnancy is feasible and acceptable for women who have used drugs. Fifty pregnant adults with hepatitis C will take glecaprevir-pibrentasvir daily for 56 days. Researchers will track how well participants stick to…

This study tests whether a once-weekly combination of two experimental drugs (islatravir and ulonivirine) works as well as the standard daily three-drug pill Biktarvy for people newly diagnosed with HIV-1. About 570 adults who have never taken HIV medication will be randomly assi…

This study tests two smoking cessation methods—varenicline pills and nicotine patches with gum—in 660 people with HIV in South Africa. Participants will receive one of these treatments for 12 weeks, along with counseling. The goal is to see which approach works best to help them …

This study tests a daily combination pill (TLD) as first-line HIV treatment for 100 people who became infected with HIV despite receiving long-acting cabotegravir PrEP in the past year. Researchers will check if the pill can suppress the virus to undetectable levels after 6 month…

This study tests whether reducing anti-rejection drugs, with or without an extra treatment called IVIG, can better control BK virus in kidney transplant patients. BK virus can damage the new kidney and lead to transplant failure. About 280 adults and children who have a kidney or…

This study tests whether specially grown immune cells (called cytotoxic T lymphocytes) can safely lower BK virus levels in 20 transplant patients with weakened immune systems. Participants have had a stem cell or kidney transplant and show signs of BK virus infection. The goal is…

This study tests a program called Friendship Bench + Safety Planning for teens aged 13-19 living with HIV who have had suicidal thoughts. The goal is to see if the program is practical, acceptable, and helps reduce suicidal thoughts and improve engagement in HIV care. Sixty parti…

This study follows about 10 adults and children (12 years and older) in Argentina who have a CMV infection after an organ transplant that did not get better with standard treatments. Researchers will track how well maribavir works and what side effects occur during routine care. …

This early-stage study tests whether infusing virus-fighting T cells from a donor can help stem cell transplant patients overcome a stubborn adenovirus infection. About 20 participants will receive the experimental cell therapy, and researchers will monitor side effects and wheth…

This phase 1 study tests a combination of two drugs, pomalidomide (a pill) and nivolumab (an infusion), in adults with cancers caused by viruses like Epstein-Barr, HPV, or hepatitis. The goal is to find a safe dose and see if the drugs can shrink tumors. Up to 58 people with Kapo…

This study tests a new supplement called PNMR in 82 adults with long COVID. Participants either take PNMR plus standard care or standard care alone for 6 weeks. The main goal is to see if PNMR helps people walk farther in a 6-minute test. All participants also get diet and lifest…

This study is testing whether a smartphone app designed for people with HIV can help them quit smoking when combined with a lung cancer screening CT scan. About 100 participants will use the app and get a low-dose CT scan. The goal is to see if this approach is practical and help…

This study tests whether dasatinib, a drug used for leukemia, can reduce the hidden HIV reservoir in people whose virus is already suppressed by antiretroviral therapy (ART). Fourteen adults on ART for at least 4 years will be randomly assigned to take dasatinib or a placebo dail…

This study tests a new approach for people with advanced lung cancer whose disease got worse after initial treatment. It combines an injected virus (Olvi-Vec) that targets cancer cells, followed by chemotherapy and an immunotherapy drug, and compares it to standard chemotherapy a…

This study tests two drugs, PDS01ADC and M7824, that work with the immune system to fight Kaposi sarcoma (KS), a cancer often linked to HIV or organ transplants. The trial enrolls 80 adults with advanced KS that has not responded well to prior therapy. Participants receive PDS01A…

This study tests whether the antiviral drug remdesivir can help treat RSV (a common respiratory virus) in people whose immune systems are weakened by certain cancer treatments or autoimmune therapies. About 60 adults with confirmed RSV will receive remdesivir intravenously. The m…

This study looks at how obesity affects recovery from post-COVID conditions in older Veterans. Researchers will test if a weight loss program with diet and exercise can reduce inflammation and improve physical function and quality of life. The study involves 150 Veterans, some wi…

This study tests a program called Full-SPARCS, where trained peers lead group sessions to help people with HIV stay in care after they leave prison in South Africa. The program includes one-on-one check-ins and group meetings in community centers. Researchers will compare viral s…

This study tests whether an internet-based depression treatment called cognitive behavioral therapy (iCBT-D) can prevent insulin resistance from getting worse in adults with HIV who are on antiretroviral therapy and have depression. Researchers will compare the online therapy pro…

This phase 2 trial tests the drug daratumumab in 28 adults with three rare and aggressive blood cancers: primary effusion lymphoma, plasmablastic lymphoma, and multicentric Castleman disease. Participants must have failed standard therapy or be unable to receive it. Daratumumab i…

This Phase 2 trial compares the drug dolutegravir alone versus dolutegravir combined with tenofovir in 146 adults with HTLV-1 infection and related symptoms. The main goal is to see if the combination lowers the virus level more effectively and improves pain, spasticity, and musc…

This early-stage study tests an injection called AHB-171 in healthy volunteers and people with chronic hepatitis B. The main goals are to check safety, how the body processes the drug, and whether it shows any signs of controlling the virus. About 110 participants will be enrolle…

This study tests several potential COVID-19 treatments in adults to find safe doses and see if they help patients recover faster. It uses a flexible 'platform' design to add new drugs quickly. The trial includes people with mild to severe COVID-19 and focuses on reducing symptoms…

This study tests whether offering a choice of e-cigarettes, nicotine pouches, or nicotine patches helps people with HIV stop smoking tobacco. About 972 participants in Switzerland will receive their preferred product free for 6 months, plus standard care. The main goal is to see …

This study tests whether a drug called letermovir is easier to tolerate than the standard treatment for preventing CMV infection in heart and lung transplant recipients. About 80 adults who have had a heart or lung transplant will take either letermovir or the usual drug, and res…

This Phase 2 trial tests an experimental drug called AHB-137 in 84 adults with chronic hepatitis B who are already on antiviral therapy. The goal is to see if AHB-137 can clear the hepatitis B surface antigen and keep the virus under control, potentially leading to a functional c…

This study in Botswana tests whether giving three powerful antibodies by infusion can help children who started HIV treatment early keep the virus suppressed without taking daily antiretroviral pills. About 41 children aged 2 to 12 will receive the antibodies while stopping their…

This study tests two drugs, VIR-2218 and peginterferon, in 50 adults with mild chronic hepatitis B. The goal is to lower the virus level in the blood and improve the body's immune response. Participants receive injections for 6 months and are followed for over 2 years, including …

This early-stage trial is testing a new treatment called DISP-10 for people with advanced gastrointestinal cancers, including colorectal and stomach cancers. The treatment combines a virus (DV-10) with specially engineered immune cells (CAR T cells) to attack cancer. The study ai…

This trial tests a program called WeCare, which combines problem-solving therapy with support for taking HIV medication. It is designed for men who have sex with men (MSM) in South Africa. The study will enroll 60 participants to see if the program reduces depression and anxiety,…

This study tests four approaches to help adults with drug-resistant tuberculosis and HIV stick to their treatments. Participants receive either standard care, counseling, phone reminders via a special pill bottle, or both counseling and reminders. The goal is to see which method …

This early-stage trial tests a lab-made antibody (HepB mAb19) in 15 people with chronic hepatitis D, a serious liver infection that requires hepatitis B to survive. The goal is to see if the antibody is safe and can lower virus levels, potentially reducing the risk of liver damag…

This study tests whether semaglutide, a drug used for diabetes, can help adults with HIV reduce their alcohol intake and smoking, and lower their risk of heart disease. About 200 participants will take semaglutide or a placebo for 3 months and provide blood, stool, and saliva sam…

This study tests if tirzepatide, a weekly injection, can help overweight or obese people with well-controlled HIV lose weight and reduce chronic inflammation. Twelve adults will receive increasing doses over 12 weeks, with a 4-week safety follow-up. Researchers will measure chang…

This study tests whether a drug called defibrotide is safe and feasible for people with severe COVID-19 pneumonia. About 42 adults with confirmed COVID-19 and lung infiltrates will receive the drug intravenously. Researchers will monitor for bleeding and low blood pressure as key…

This study tests a long-acting injectable HIV medication (CAB LA + RPV LA) in people whose virus is still detectable despite taking daily oral pills. About 332 participants will either get the shots or continue standard oral therapy. The goal is to see if the injections can bette…

This study tests a drug called maribavir for children and teens who have a CMV infection after a stem cell or organ transplant. About 80 participants will take the drug for 8 weeks and be followed for 12 more weeks. The goal is to find the safest dose and see how well it controls…

This early-phase study tests an oral antiviral drug called letermovir in 12 infants born with symptomatic congenital cytomegalovirus (CMV) infection. The goal is to find the right dose and see if it safely lowers the amount of virus in the body. Babies also receive standard treat…

This phase 3 trial tests tabelecleucel, a cell therapy made from donor immune cells, in 115 organ or stem cell transplant patients who developed a rare cancer (EBV+ PTLD) after standard treatment failed. The goal is to see if it can shrink tumors and improve outcomes. Participant…

This study looks at whether the HIV drug cabotegravir is safe for newborns who were exposed to HIV during birth. About 44 healthy babies will receive the drug either by mouth or injection. The goal is to find the right dose and check for side effects, helping to protect these inf…

This phase 2 trial tests whether adding tesamorelin (a growth-hormone-releasing hormone analogue) to a home-based exercise program can improve physical function in 100 adults aged 50-80 with HIV. Participants are randomly assigned to receive tesamorelin or a placebo injection dai…

This study tests whether adding the malaria drug artesunate to standard antiviral treatment can better control cytomegalovirus (CMV) infection in people who have received a solid organ transplant (kidney, lung, heart, or liver). About 90 adult participants will receive either a l…

This study tests whether a special placental graft, used alongside standard wound care, helps close diabetic foot ulcers that won't heal on their own. About 350 adults with type 1 or 2 diabetes and a foot ulcer between 1 and 15 cm² will be randomly assigned to get the graft plus …

This Phase 2 trial tests a new drug called AHB-137, given alongside a hepatitis B vaccine or peginterferon, in 200 adults with chronic hepatitis B who are already on antiviral pills. The goal is to see if the combination can clear the hepatitis B surface antigen (HBsAg) from the …

This study tests a program called ARC that helps HIV clinics improve their work environment and reduce discrimination. Researchers will compare viral suppression and care retention in clinics using ARC versus standard care. The goal is to see if better clinic culture leads to bet…

This study is testing a long-acting injectable medication for children aged 2 to 12 who have HIV and whose virus is already under control. The goal is to see if switching from daily pills to a shot given every few weeks is safe, tolerable, and effective. About 90 children will pa…

This study tests whether a mobile app with a virtual group support feature can help young Black women (ages 18-30) who misuse alcohol reduce their drinking and risky sexual behavior, and increase their use of PrEP (a daily pill that prevents HIV). About 500 HIV-negative women in …

This study tests a program called PrTNER that helps young people aged 15-29 who are at risk for HIV or already living with it, and who also have substance use issues. The program provides prevention, treatment, and support to help them start HIV prevention medication (PrEP) or lo…

This study tests whether a vaginal suppository called Dysplasix can help women clear high-risk human papillomavirus (HPV) and reverse low-grade cervical abnormalities. About 45 women with HPV and mild cervical changes will use the suppository or a placebo for 19 days. Researchers…

This study tests a program called Mlambe for married couples in Malawi where one partner drinks heavily and both are affected by HIV. The program offers savings accounts, money management classes, and relationship skills training to help couples reduce alcohol use. Researchers wi…

This early-stage trial tests whether a specially engineered herpes virus (G207) is safe to inject directly into the brain tumors of children whose cancer has returned. Up to 24 children aged 3 to 21 will receive the virus, and some will also get a small dose of radiation to help …

This study tests whether the steroid dexamethasone can reduce brain damage in adults hospitalized with tick-borne encephalitis. Researchers will compare disability outcomes in 200 patients who receive either dexamethasone or a placebo. The goal is to see if this treatment lowers …

This project aims to make hepatitis C testing and treatment easier for people who visit drug treatment clinics and needle exchange programs. Researchers will work with clinics across New South Wales, Australia, to help more people start treatment. The study includes up to 6,000 a…

This study compares two antiviral drugs, tenofovir alafenamide (TAF) and entecavir, in 140 adults with chronic hepatitis B. The goal is to see which one controls the virus better and causes fewer kidney problems. Participants take one pill daily for about a year.

This study tests whether a mobile app called HBVCare can help people with chronic hepatitis B take their medication regularly and attend follow-up visits. About 70 adults in Vietnam will either use the app or receive standard care. After 3 months, researchers will compare how wel…

This early-stage trial is testing whether injecting the local anesthetic lidocaine into HPV-related throat tumors before robotic surgery is safe and might help destroy more cancer cells. About 30 adults with HPV-positive oropharyngeal cancer will receive the injection during a ro…

This study tests whether baricitinib, a drug used for arthritis, can improve thinking, physical function, and quality of life in people with Long COVID. About 550 adults who had COVID-19 at least 6 months ago will receive either baricitinib or a placebo for 6 months. The main goa…

This study tests a program called Kisoboka for men living with HIV who drink heavily in fishing communities. The goal is to help them drink less, take their HIV medication as prescribed, and achieve undetectable viral loads. About 716 men will be randomly assigned to different co…

This early-stage study tests whether a new oral drug called VNT-101 is safe for people. About 78 healthy adults aged 18-59 will receive either the drug or a placebo. The goal is to check for side effects and how the body processes the drug, not yet to treat the flu.

This study is testing an experimental injection called LP-98 in 30 adults with HIV who have never taken HIV medication. The goal is to see if the drug can safely lower the amount of virus in the blood and improve immune cell counts. Participants will receive the injection and be …

This study tests whether personalized text messages can help HIV-positive women in Africa who sell sex take their antiretroviral therapy (ART) regularly. 350 women will either get standard care or standard care plus text reminders and tips for six months. The goal is to see if mo…

This study tests a new medicine called CP-COV03 in adults with dengue fever. The goal is to see if it can safely lower the amount of virus in the blood and help people feel better faster. About 210 participants will receive either the drug or a placebo. The trial is currently rec…

This study tests whether giving newborns plasma from people who recently recovered from chikungunya can prevent brain swelling or damage. The trial will include 60 newborns whose mothers were infected around the time of birth. Half will receive the plasma transfusion, and their o…

This study tests a lab-made human protein called CYT107 in 55 people with HIV and Kaposi sarcoma. The protein aims to boost T cells, which may help shrink cancer tumors. Participants receive weekly injections for up to 4 weeks, with follow-up for 3 years.

This study is testing a new experimental drug called VH4524184 for people with HIV-1 who have never taken HIV medication before. About 150 adults will receive either a low or high dose of VH4524184 along with two standard HIV drugs (emtricitabine and tenofovir alafenamide), or a …

This early-stage trial tests whether venetoclax, a drug used for certain blood cancers, can help eliminate the hidden HIV reservoir. The study enrolls 38 adults newly starting HIV therapy. Participants receive venetoclax in three short cycles while researchers monitor safety and …

This study tests a program called Tunawiri (meaning 'thrive') that adds mental health screening, counseling, and support to regular HIV care for pregnant and postpartum women in Kenya. The goal is to improve depression, anxiety, and HIV treatment success. Nine hundred women will …

This study checks if people with chronic hepatitis B who got better with the drug AHB-137 stay virus-free over time. About 200 adults who already responded to AHB-137 will be followed for years. The goal is to see if the virus stays undetectable and if liver health improves witho…

This Phase 3 trial tests whether a combination of two drugs, tobevibart and elebsiran, can suppress hepatitis D virus in adults who are still infected despite taking bulevirtide. About 150 participants will receive the combo as injections. The main goal is to see if the virus bec…

This Phase 2 trial tests an injection called AHB-137 in 60 adults with chronic hepatitis B who are already on antiviral pills. The goal is to see if the drug can lower virus levels enough that patients can safely stop all treatment. The study will check if the virus stays undetec…

This study tests whether the antiviral drug letermovir can prevent cytomegalovirus (CMV) infection in children and teens who have had a stem cell transplant. About 105 participants aged 2 to 17 will receive letermovir and be monitored for 14 weeks. The goal is to see if the drug …

This study tests a drug called abemaciclib, already used for breast cancer, in people with Kaposi sarcoma (KS), both with and without HIV. The goal is to find a safe dose and see if it can shrink KS tumors. About 111 adults will take the drug daily in 28-day cycles until their ca…

This study compares two antibiotics for treating early syphilis: a single penicillin shot (standard care) versus a 14-day course of cefixime pills. Researchers want to see if the pill works just as well. The study includes 400 adults with early syphilis, including those with well…

This study follows people who already took part in earlier YCANTH wart studies. It tests whether up to 4 more treatments, applied every 21 days, can safely clear common warts. About 600 adults and children will be monitored for a year. The goal is to see if the medicine continues…

This study tests whether resmetirom, a drug already approved for another liver condition, can safely reduce liver fat in people with HIV who also have fatty liver disease (MASLD). About 120 adults with well-controlled HIV will take either resmetirom or a placebo daily for 24 week…

This study provides free testing for chlamydia, gonorrhea, syphilis, and HIV to Black youth aged 15-26 in New Orleans. Those who test positive can get treatment at no cost and are encouraged to bring their partners. The goal is to reduce STI rates and health disparities in this c…

This study tests a program led by trained peers (other women with HIV) that combines acceptance and commitment therapy, exercise, and social support. The goal is to help 300 women in four counties stick to their HIV medication and manage substance use and trauma. Researchers will…

This Phase 2 study tests an experimental drug called ALG-000184 against a standard hepatitis B medication (tenofovir) in 200 adults with chronic hepatitis B. Participants take one pill daily for 48 weeks. The main goal is to see if the new drug can lower hepatitis B virus levels …

This study looks at how well the flu drug baloxavir marboxil works in children under 12 and whether it stops the flu from spreading to family members. About 1,100 kids with flu symptoms will take the drug, and researchers will check for drug resistance and track infections in hou…

This phase 2 trial is testing two antivirals—molnupiravir (used for COVID-19) and a lab-made antibody called VIS513—in 500 people with early dengue. Participants must have had fever for less than 48 hours and a positive rapid test. The goal is to see if these drugs can clear the …

This study aims to create and test a clinical prediction score called FUNGAL-P to help doctors identify fungal pneumonia early in adults who come to the hospital with pneumonia. Researchers will analyze medical records from past patients and then test the score on new patients to…

This study investigates whether urine samples can be used to screen for cervical cancer in women living with HIV. Researchers will compare the accuracy of urine HPV testing with self-collected and provider-collected samples to detect cervical precancer (CIN2 or worse). The goal i…

This study is testing whether self-collected vaginal samples for HPV testing work as well as samples collected by a doctor during a pelvic exam. The goal is to make cervical cancer screening more accessible and comfortable. About 500 people referred for colposcopy or cervical pro…

This study looks at 200 adults with inflammatory bowel disease (IBD) who are hospitalized due to worsening symptoms. Researchers want to see if testing blood or stool for CMV (a common virus) is as accurate as the standard method of testing a tissue sample from the colon. The goa…

This study tests a new way to collect and transport samples for mpox diagnosis using a special paper strip treated with SDS and EDTA. The strip inactivates the virus, making transport safer, and stabilizes the genetic material so cold storage isn't needed. Researchers will compar…

This study is testing a new rapid diagnostic test for Crimean-Congo hemorrhagic fever (CCHF) that gives results in 20 minutes. Researchers will enroll 492 adults in Turkey with suspected CCHF to see if the test is accurate compared to standard lab methods. The goal is to provide …

This study tests a decision-support tool called MyCMV that helps doctors interpret blood test results for cytomegalovirus (CMV) infection during pregnancy. CMV is a common virus that can cause hearing loss and developmental problems in babies if the mother catches it for the firs…

This study compares two ways to offer cervical cancer screening to women living with HIV: standard clinic-based screening versus adding community outreach where health workers provide HPV self-collection kits at home or in community settings. About 7,600 women across multiple cli…

This study is testing a new, portable breath test called eBAM-CoV to see if it can detect COVID-19 as accurately as the standard nasal swab test (RT-PCR). The breath test is less invasive and gives immediate results. Researchers will compare the two tests in 250 adults who have s…

This study is testing whether measuring a natural immune marker called IFN-I in nasal swabs can help detect respiratory viral infections in older adults. Current PCR tests only look for a few viruses and can miss others or show old infections. The goal is to improve diagnosis, es…

This study is testing a new point-of-care diagnostic test for HPV, called the Rice HPV test, to see if it works as well as standard tests. Researchers at MD Anderson Cancer Center will enroll 600 people with a cervix aged 21 or older. The goal is to develop a test that requires l…

This study tests whether offering a self-sampling kit for HPV in the emergency department can increase the number of people who get screened for cervical cancer. About 200 eligible individuals (ages 30-65 with a cervix) will be offered the kit while in the ED. The goal is to see …

This study is testing a new rapid diagnostic device called TruPlex that can detect HIV, Hepatitis B, and Syphilis from a small blood sample. Researchers will enroll 1000 adults at risk for these infections to see how accurate and easy the test is to use in clinics and point-of-ca…

This early-phase trial tests a vaccine (CMV-MVA Triplex) given to both stem cell donors and recipients to boost immunity against cytomegalovirus (CMV) and prevent active infection after a half-matched stem cell transplant. About 46 people with various blood cancers will take part…

This study tests whether text messages about HIV prevention, sent to dental patients at community health centers, can increase HIV testing and use of preventive medications like PrEP. About 266 HIV-negative adults with at least one HIV risk factor will receive either HIV-focused …

This study looks at how well people stick to a new HIV prevention shot called lenacapavir. About 3,000 people in the U.S. who want or need HIV prevention will take part. Researchers will track who stays on the shot and how it works in everyday clinic settings.

This phase 3 trial tests MK-8527, a once-monthly oral pill, to prevent HIV-1 infection in women. About 4580 HIV-negative women will take either MK-8527 monthly or a daily PrEP pill (Truvada) to see which works better and is safer. The goal is to offer a more convenient prevention…

This large phase 3 trial is testing whether a new oral pill called MK-8527, taken just once a month, can prevent HIV infection as well as the standard daily PrEP pill. About 4,390 people at risk of HIV will be randomly assigned to receive either the monthly pill or daily Truvada …

This study tests a program called SAKHI HPV for women in India who have both HPV and HIV. The program provides support from community health workers, group sessions, and nutrition education to help women stay healthy and reduce their risk of cervical cancer. Researchers will comp…

This study tests whether a mobile app plus virtual peer support can help young men who have sex with men (ages 16–25) start and stick with PrEP, a daily pill that prevents HIV. The app provides sexual health information and connects users with a peer navigator who can guide them …

This study tests a quick digital toolkit that teaches cisgender women about PrEP, a daily pill that prevents HIV. About 125 women at clinics in Alabama and Mississippi will use the toolkit on a tablet and then talk with a healthcare worker about starting PrEP. Researchers want to…

This study tests a program called JUNTOS that helps HIV test counselors refer Latino men who have sex with men to prevention and treatment services. The goal is to see if this referral network increases the number of men who use HIV prevention or get treated. About 245 participan…

This study tests a mobile health program called WINGS+PrEP for women who have experienced heavy drinking, partner violence, and involvement with the criminal legal system. The program provides information about PrEP (a daily pill that prevents HIV) and offers support sessions. Re…

This study tests a new way to offer HIV prevention pills (PrEP) to people visiting family planning clinics in Kenya. Instead of requiring a separate appointment, HIV counselors will provide PrEP screening and prescriptions right at the family planning visit. The goal is to see if…

This study tests four different approaches to help people who inject drugs remember and stick with their daily HIV prevention pill (PrEP). Researchers will enroll 256 adults who are newly on medication for opioid use disorder and have started PrEP. The goal is to see which method…

This study is looking at whether it's safe and effective to give the Tdap vaccine (for whooping cough) and the RSV vaccine at the same doctor's visit during pregnancy, or if they should be given separately. The researchers will recruit 60 healthy pregnant individuals and randomly…

This study in Botswana tests whether offering sexually transmitted infection (STI) testing alongside HIV prevention medication (PrEP) helps more pregnant women start and continue using PrEP. About 600 pregnant women without HIV will be split into two groups: one gets standard car…

This study is developing and testing a virtual reality tool to help young people aged 15-30 who have experienced trauma and are at risk for substance use and HIV. The goal is to see if the tool can reduce substance use and risky behaviors. Researchers are recruiting young men who…

This study tests whether at-home HPV self-sampling (using urine or a vaginal swab) can help more people get screened for cervical cancer compared to the traditional in-clinic Pap smear. About 735 Latinx individuals aged 30-65 who haven't had a Pap test in at least three years wil…

This study tests whether a monthly injection of naltrexone can prevent fentanyl overdose in people who use stimulants like cocaine or methamphetamine but do not intentionally use opioids. One hundred participants will either receive the shot or standard harm reduction supplies. R…

This study aims to make cervical cancer prevention easier for women who often miss out on routine care, such as those experiencing homelessness, substance use, or incarceration. Researchers will offer the HPV vaccine (Gardasil-9) and a self-swab test during regular sexual health …

This study tests a digital health program to help women involved in the criminal justice system start PrEP (a daily pill to prevent HIV) and get treatment for opioid use disorder. Researchers will compare the program to a simpler decision aid alone. The goal is to reduce stigma a…

This study tests whether giving HIV prevention pills (PrEP) to people right in the emergency room helps them start and stay on prevention. Researchers will enroll 250 HIV-negative adults at risk for HIV in Dallas. Participants get a 30-day pill supply and a clinic appointment to …

This study tests a personalized approach to stopping the drug Letermovir, which prevents a common virus called CMV after a stem cell transplant. Instead of giving the drug for a fixed 100 days, doctors will use a blood test to see when a patient's own immune system has recovered …

This study tests whether giving the flu vaccine to heart patients just before they leave the hospital can lower their risk of infections, heart problems, and death in the next 6 months. About 400 adults hospitalized for serious heart conditions will be randomly assigned to get th…

This study tests an online program called UPDOs Protective Styles to help Black women in the southeastern US learn about and start using PrEP, a medicine that prevents HIV. Researchers will recruit 1000 participants from 32 beauty salons in areas with high HIV rates. One group wi…

This study looks at whether patients and doctors in a family planning clinic find it acceptable to discuss and start PrEP, a daily pill that prevents HIV. About 83 English- or Spanish-speaking patients aged 16 and older, along with their doctors, will take part. Patients will rec…

This study tests whether giving nurses and doctors special training and allowing nurses to give the HPV vaccine without a doctor's order can increase vaccination rates. About 16,000 teens aged 9-17 from 40 medical practices will take part. The goal is to prevent HPV-related cance…

This early-stage study is testing whether two lab-made antibodies, PGT121.414.LS and VRC07-523LS, are safe for newborns who were exposed to HIV during birth. The 48 infants will receive one or two shots of the antibodies under the skin. Researchers will monitor for side effects a…

This study combines peer navigation (trained community members) with mobile health tools to help gay, bisexual, and transgender people in rural Appalachia access HIV, STI, and hepatitis C testing and prevention services. About 141 participants will be split into two groups: one g…

This study tests whether giving both an RSV vaccine to pregnant women and an antibody shot to their babies prevents RSV infection better than giving only the baby shot. About 1000 pregnant women in France will be randomly assigned to one of two groups. The goal is to see if the c…

This study expands on a previous mobile van HIV/STI testing program for men who have sex with men (MSM) in online spaces. Researchers will add a peer health navigator to help participants get PrEP or HIV care after testing. The study will compare this navigator approach to a refe…

This pilot study tests whether a peer-driven program can help people who inject drugs in Baltimore reduce their risk of HIV, hepatitis C, and overdose. Researchers will identify high-risk injection settings and train peers to promote safer practices, like carrying naloxone and av…

This study compares two strategies to help clinics increase HPV vaccination rates among children aged 9-17. One strategy provides online communication training for providers; the other adds a learning collaborative with performance feedback. The goal is to see which approach work…

This pilot study tests whether a health-themed video game can encourage HPV vaccination among underserved youth aged 11-14 who have not yet received the vaccine. About 180 parent-child pairs will play the game and report their vaccination intentions and actual shots. The goal is …

This study tests a program called CUPID that helps couples make decisions together about HIV prevention. About 1,424 women in Uganda will join with their male partners to choose and use PrEP (medicines that prevent HIV). The goal is to see if partner support increases women's use…

This early-stage study is testing an experimental antibody called MDX2301 to see if it can help prevent severe COVID-19 in healthy adults and those at higher risk. About 80 participants will receive either the antibody or a placebo, given as an injection or infusion. The main goa…

This study looks at how well a live shingles vaccine prevents shingles over 6 years in adults aged 40 and older. It follows about 24,740 people who were in an earlier vaccine trial, comparing those who got the vaccine first to those who got it later. Researchers will track new sh…

This study aims to make HIV prevention easier to access for underserved groups in Rio de Janeiro, such as gay and bisexual men, transgender women, and sex workers. Instead of requiring clinic visits, participants can get daily PrEP pills and support through community organization…

This study tests whether community health workers can help adults with chronic illnesses get up-to-date on COVID-19 and flu vaccines. Participants receive up to three counseling sessions in English or Spanish to address their vaccine concerns. The goal is to reduce health dispari…

This study tests a smartphone app called MY-RIDE that offers just-in-time support and nurse-led sessions to help homeless youth reduce substance use and adopt HIV prevention methods like PrEP. 450 participants aged 15-24 who are homeless, use substances, and are sexually active w…

This study is testing whether the Shingrix vaccine, already used to prevent shingles, can also lower the risk of dementia in adults aged 76 and older. Over 33,000 participants in Finland will receive either the vaccine or a placebo. Researchers will track new dementia diagnoses o…

This study tests an online program called all2GETHER that teaches relationship and communication skills to gay, bisexual, and queer men, as well as transgender and non-binary people who partner with cisgender men. The goal is to see if the program can lower HIV and STI rates. 5,0…

This study tests two approaches to help men who have sex with men and use methamphetamine start or restart HIV prevention (PrEP) or treatment (ART). 400 participants will receive either contingency management (rewards for filling prescriptions) alone or combined with motivational…

This study looks at the safety of two HIV prevention methods (a long-acting shot and daily pills) in pregnant and breastfeeding women in Malawi. About 621 women who are already using or start these drugs during pregnancy will be followed along with their infants. The goal is to s…

This large study in Denmark is testing whether the shingles vaccine (Shingrix) can do more than prevent shingles—it may also lower the risk of heart attacks, strokes, and dementia. About 162,000 adults aged 65 and older will either get the vaccine or no vaccine, and researchers w…

This study in Uganda tests whether offering HIV self-testing and PrEP (a daily pill to prevent HIV) at home during routine TB contact tracing can increase HIV prevention. About 2,480 people from households with a TB patient will be randomly assigned to either home-based HIV testi…

This study tests whether training and supporting healthcare providers can increase HPV vaccination rates among Latino adolescents. Researchers will work with nine health centers to implement strategies like provider education and clinical plans. The goal is to see if these effort…

This study tests an oral drug called vapendavir in 180 adults with COPD who catch a rhinovirus (common cold). The goal is to see if it can reduce the severity and length of breathing symptoms compared to a placebo. Participants are randomly assigned to one of two doses or a place…

This study tests a new pill containing three ingredients (dipyrone, caffeine, and chlorpheniramine) to see if it works as well as a standard cold medicine for relieving stuffy nose and other cold and flu symptoms. About 620 adults with early cold or flu symptoms will take either …

This study tests whether using a mobile app that gives visual feedback can help lung cancer patients do breathing exercises more effectively after having part of a lung removed. Forty patients will try both standard breathing training and app-guided training on the same day. Rese…

This study compares two drugs, pramipexole and escitalopram, to treat major depression in people with HIV. Some participants also have mild memory or thinking problems. The goal is to see which medication is safer and more effective at easing depression symptoms. About 186 adults…

This study is testing four medical devices (PIR, NS, NHE, NHG) in 150 adults with acute viral rhinitis, rhinosinusitis, or rhinopharyngitis (common cold). The goal is to see if they are safe and help reduce symptoms like sneezing, runny nose, and sore throat. Participants use the…

This study looks at whether electroacupuncture (a type of acupuncture with mild electric pulses) can help relieve pain from shingles and reduce the chance of long-term nerve pain. About 228 adults with shingles will be split into three groups: one gets electroacupuncture plus sta…

This study tests two types of smell training in 80 adults aged 40+ with HIV. Participants will sniff scents at home twice a day for 8 weeks. The goal is to see if the training is easy to do and if it improves smell and thinking abilities.

This study is testing a type of talk therapy for people who have both HIV and PTSD. The therapy helps people understand how trauma affects their emotions and relationships. The goal is to see if this therapy is helpful and acceptable for this group. About 20 adults with HIV and P…

This study is for primary caregivers in the Bronx who feel stressed. It tests a 12-week program called CARE, plus a phone app (Valera) that gives parenting tips and connects families to a care manager. The goal is to see if these tools can lower stress and help parents support th…

This study tests a telehealth program called MCBMAP that combines counseling and skills training to help people with HIV reduce chronic pain and unhealthy drinking. The program is delivered entirely through video calls and online materials, making it easier for participants to jo…

This pilot study tests a mobile game called Change My Story, designed to help young people (ages 16-24) living with HIV who also have depression. The game uses a choose-your-own-adventure format to teach coping skills, and is combined with problem-solving therapy. Researchers wil…

This study tests a home-based exercise program for people who were hospitalized with severe COVID-19. Participants use a smartphone app to guide them through high-intensity interval training and other exercises. The goal is to see if this approach improves walking ability, fitnes…

This study tests whether taking fish oil for 12 weeks can help the body adapt to cold by activating brown fat, which burns energy to produce heat. Thirty healthy adults aged 18-40 will take either fish oil or a placebo and then undergo a cold chamber challenge. Researchers will m…

This study looks at whether hormone therapy (estrogen with or without progesterone) can safely reduce hot flashes and night sweats in women living with HIV. Researchers will also check if it improves sleep, mood, thinking, bone health, and quality of life. About 105 women aged 40…

This study tests two different nerve blocks to control pain after video-assisted lung surgery. One block targets a muscle plane, the other targets individual nerves. Researchers will measure pain levels, opioid use, and breathing problems in 80 adults aged 18-80. The goal is to f…

This study is testing a hypertonic seawater aerosol spray (a saltwater mist) to see if it helps relieve nasal symptoms, improve sleep, and thin mucus in people with colds, sinus infections, or similar upper respiratory infections. About 110 adults and children aged 2 and older wi…

This study tests a powered leg brace called the Nomad in 36 people who have trouble walking due to conditions like stroke, multiple sclerosis, or spinal cord injury. Participants will use the brace at home for three months to see if it improves their walking speed, balance, and q…

This pilot study is testing whether chiropractic care can improve quality of life and reduce inflammation in adults with HIV. Researchers will compare a group receiving weekly chiropractic adjustments to a group receiving no treatment. The study aims to see if a larger trial is p…

This study tests whether combining heat therapy (hyperthermia) with a common antiseptic (3% hydrogen peroxide) can clear stubborn viral warts that haven't responded to other treatments. About 80 adults with warts lasting two years or more will receive either the combination treat…

This study tests whether a single dose of baloxavir marboxil (Xofluza) can help adults hospitalized with severe flu recover faster. About 484 participants in Switzerland will receive either the drug or a placebo. Researchers will measure time to clinical improvement, hospital sta…

This study looks at why some people with HIV who have very low virus levels in their blood still develop thinking and memory problems. Researchers will follow 1,150 participants—including healthy volunteers—for up to 10 years, using brain scans, blood tests, and spinal fluid samp…

This study follows people infected with HTLV-I virus, some of whom develop a rare spinal cord condition called HAM/TSP. Researchers will track changes in symptoms, immune system markers, and virus levels over time. The goal is to better understand why only a few infected people g…

This study aims to learn more about liver diseases like hepatitis B, C, and D by observing up to 8,050 participants over time. Participants will have yearly check-ups, blood and urine tests, and liver ultrasounds. Some may be offered experimental treatments if they qualify. The g…

This early-phase study will give 9 healthy adults a single dose of the experimental HIV drug VH4524184, plus a tiny radioactive version to track it. Researchers will measure how much of the drug gets into the blood, how it's broken down, and how it leaves the body through urine a…

This study aims to understand how HIV behaves differently in the blood compared to lymph nodes and bone marrow. Researchers will take samples from 400 people living with HIV and some without HIV to measure virus levels and immune system changes. The goal is to learn more about wh…

This study looks at people who have had unusually severe or long-lasting viral infections, like serious cases of herpes, HPV, or the flu. Researchers want to find out if these people have hidden immune system or genetic problems that make them more vulnerable. Up to 600 participa…

This study aims to collect samples and medical information from people of all ages who have or have been exposed to viral infections, including COVID-19 and herpes. Researchers want to understand how viruses affect healthy individuals versus those with weakened immune systems. Pa…

This study looks at how the monkeypox vaccine (MVA-BN) sparks immune responses in 100 adults at high risk of infection, including those with and without HIV. Researchers will measure antibodies and other immune markers in blood samples taken after vaccination. The goal is to unde…

This study will test a new 3D imaging device called SkinScan3D to see if it can measure Kaposi Sarcoma skin lesions more accurately and consistently than the current manual method. Researchers will compare the two methods in 300 adults with confirmed Kaposi Sarcoma who are starti…

This study screens up to 5,000 healthy adults aged 18-65 to see if they can join future research on infectious diseases like flu and Zika. Volunteers undergo a 3-5 hour checkup including blood tests, heart exam, and chest X-ray. The goal is to build a pool of eligible participant…

This study collects blood, bone marrow, and tissue samples from people with HIV, KSHV, or certain cancers to help researchers learn more about these diseases. Participants must be 18 or older and may have HIV, KSHV, or related conditions. No treatment is given; the goal is to gat…

This study follows 600 people with GATA2 deficiency, a genetic disorder affecting the immune system and other body systems. Researchers aim to understand the full range of health problems it causes and why it affects people differently. Participants will have yearly check-ups for…

This study looks at how natural hormones and hormone therapy (like birth control or gender-affirming hormones) affect the way the HIV prevention drug cabotegravir works in the body. Researchers will measure drug levels in blood, tissues, and fluids in 32 HIV-negative adults. The …

This study investigates how depression and cannabis use together affect brain circuits involved in reward and pain in young people living with HIV. Researchers will use MRI scans and questionnaires to measure brain activity, mood, and substance use. The goal is to understand why …

This study looks at skin problems that appear during a COVID-19 infection, with a special focus on chilblains (painful red or purple bumps on fingers or toes). Researchers want to understand why these skin changes happen—whether from the virus itself, tiny blood clots, or inflamm…

This study follows a large group of people with HIV over many years to track their health, treatments, and any complications. Researchers will collect medical data during regular clinic visits to better understand how the disease and its treatments affect patients over time. The …

This study looks at how the immune system changes with age and how that affects the risk of infections in people 60 and older. Researchers will collect blood, urine, stool, and other samples from elderly patients with infections and healthy older adults. By analyzing immune cells…

This registry study is collecting blood and urine samples from 60 kidney transplant recipients who have BK virus infection. Researchers want to understand how the immune system responds to the virus and how immunosuppressive drugs affect that response. The goal is to find better …

This study tests whether giving clinics a dedicated coach helps them offer alcohol treatment to people with HIV who drink too much. The coach provides tools and guidance to support a stepped care model, which starts with brief advice and progresses to therapy or medication if nee…

This study tests a program to help people on long-acting injectable HIV prevention (LAI-PrEP) with social needs like food, housing, and transportation. Researchers will screen participants every 4 months and connect them with community organizations for support. The goal is to se…

This study follows 700 people with progressive multifocal leukoencephalopathy (PML), a rare brain infection caused by the JC virus. Researchers will collect blood, spinal fluid, and brain scans over time to understand how the disease progresses. No treatment is given; the goal is…

This study collects white blood cells and plasma from 400 people with HIV, including rare 'non-progressors' who control the virus without medication. Researchers will analyze immune responses and genetic markers to understand what makes these individuals special. The goal is to u…

This study reviews medical records of over 5,600 people with HIV to see how many might need special dental care due to low immune cells or blood issues. The goal is to help dentists know when to take extra steps and when standard care is safe, reducing stigma. It is an observatio…

This study collects blood, bone marrow, and tumor samples from 500 adults with cancer or pre-cancerous conditions. Researchers will use these samples to learn more about how cancers behave and why some respond differently to treatments. Participants provide samples over time and …

This study in South Africa works with women who have HIV and abnormal Pap results to find out why some don't follow up for cervical cancer care. Researchers will interview patients and providers, then create a short counseling and navigation program. They will test if the program…

This study compares two sets of strategies to help HIV clinics in Cape Town, South Africa, treat depression and improve medication adherence. Ten clinics will be randomly assigned to receive either basic support or enhanced training and supervision. Researchers will track how man…

This study collects tissue and blood samples from adults with HIV, other immune disorders, or cancers thought to be caused by viruses. Researchers will compare genes in cancer tissue to normal tissue to find genetic changes that drive these cancers. The goal is to better understa…

This study tracks 1,500 people over two years to see how the COVID-19 pandemic has changed their drinking habits and related stress. Participants complete surveys about alcohol use, stress, and well-being, comparing before and during the pandemic. The goal is to understand the pa…

This study looks at HIV that stays hidden in the body even when the virus is under control. Researchers will measure the 'latent HIV reservoir' in 130 Ugandans with HIV and compare it to similar groups in the US. Participants give blood samples and answer health questions. No new…

This study aims to find out how often people with chronic hepatitis B also have hepatitis D, and which types of the virus are most common. Researchers will interview about 2,400 participants and take blood samples to look for links with vaccination history, lifestyle, and other f…

This study looks at heart health in children five years after they had MIS-C, a rare but serious condition linked to COVID-19. Researchers will compare 90 children who had MIS-C with healthy children of the same age and sex. They will use heart imaging, blood vessel checks, exerc…

This study uses a device called FibroScan to measure liver stiffness and fat content in people with liver disease. The scan is non-invasive, like an ultrasound, and takes only a few minutes. Researchers aim to build a large database of these measurements to help improve future di…

This study is following 1,000 people in the Alpes-Maritimes region of France to see how many were infected with the coronavirus during the deconfinement period. Researchers are using blood tests to measure immune responses and will also look at how air pollution might affect the …

This study looks at people with HIV who are 75 or older and take at least five medications regularly. Researchers want to understand how this 'polypharmacy' affects healthy aging and quality of life. They will interview participants and review their medical records to count medic…

This study enrolls healthy adults who are already part of a respiratory virus challenge study at the NIH. Participants wear a smartwatch and use a smartphone to track temperature, heart rate, coughs, and other health signals. The goal is to see if these devices can detect subtle …

This study in South-East Austria looks at past lab results to find people with hepatitis B, C, or D who may not know they have it. Researchers will invite these individuals to a clinic to discuss treatment options. The goal is to connect them to care and track how many get cured,…

This study talks to people living with HIV from diverse backgrounds to learn what helps or hinders them from getting oral health care and cancer prevention. Researchers will hold focus groups and use questionnaires to understand barriers and gather ideas for improvement. The goal…

This study aims to understand where HIV hides in the body when people stop their daily antiretroviral therapy (ART) for a short time. Fifty adults with HIV will either stay on ART or pause it for up to 90 days. Researchers will use PET/CT scans and take small tissue samples from …

This study aims to learn more about how HIV infects cells and affects the immune system by collecting blood samples from up to 2,419 adults, both with and without HIV. Researchers will analyze these samples to compare genetic and protein differences. The goal is to better underst…

This study is testing different methods to detect COVID-19 infections and measure immunity. Researchers will use PCR tests to find active infections and antibody tests to see who has been infected before. Up to 2500 volunteers, including staff and their families, will participate…

This study collects blood, urine, bone marrow, and tissue samples from over 1,200 adults with lymphoid cancers or precancerous conditions. The goal is to help researchers better understand cancer biology, which may lead to new methods for diagnosing or treating these diseases. No…

This study follows 300 infants to understand how catching RSV very early (before 4 months old) versus later (after 6-9 months) affects their immune system and long-term health. Researchers will measure antibody responses and track asthma-like symptoms. The goal is to learn why ea…

This study follows 950 people with idiopathic CD4+ lymphocytopenia (ICL), a rare condition where low CD4+ white blood cells raise infection risk. Researchers will track participants for up to 10 years, collecting medical history, blood samples, and infection data. The goal is to …

This study aims to find out how common anti-annexin A2 antibodies are in people hospitalized with COVID-19 and whether these antibodies are linked to lung damage or blood clots. Researchers will test blood samples from 300 adult patients at one hospital. The goal is to see if the…

This study tracks the health of people with HIV over time to learn more about the infection and related conditions. It is for adults 18 and older in the Washington, D.C., area who have or may have HIV. Participants visit the clinic every few months for check-ups and blood tests, …

This study aims to improve how doctors evaluate and manage people who have been exposed to bioterrorism agents (like anthrax) or emerging infectious diseases (like SARS or new flu strains). Up to 200 participants, including patients and healthcare workers, will be monitored and t…

This study looks at how people with endometrial cancer find medical information and how satisfied they are with it. Researchers will also ask patients if they'd be interested in using an AI-powered educational tool. The goal is to understand current needs and see if AI could help…

This study is looking at 100 adult patients who have had an organ or stem cell transplant and later developed a CMV infection that is resistant or hard to treat with standard antiviral drugs. Researchers want to find out how common this problem is and what factors make it more li…

This study follows 400 people with mitochondrial disease and their household members to learn how infections affect them. Researchers will analyze blood samples and health records to find immune patterns linked to severe illness. The goal is to improve care and identify potential…

This study tests whether short educational videos can help young adults who survived childhood cancer learn about and get the HPV vaccine. The researchers will enroll 55 survivors aged 18-26 who haven't finished the vaccine series. Participants will watch the videos on Facebook a…

This study follows 650 adults who had pneumonia (including COVID-19) to see how the infection might lead to heart disease later. Researchers will collect blood samples, run heart and lung tests, and track heart attacks, strokes, and other events over three years. No new treatment…

This early-stage study tests a new combination capsule (Ingavirin Forte) that contains two active ingredients against the standard single-ingredient Ingavirin. The goal is to see how the body processes each version and whether the combination is safe. Thirty-six healthy adults wi…

This study follows 420 adults with HIV whose virus is fully suppressed by medication. Researchers want to see if switching to a different HIV drug regimen causes hidden drug resistance to appear. They will compare people who switch drugs with those who stay on their current treat…

This study aims to understand how well the seasonal flu vaccine works in children with blood cancers like leukemia. Researchers will measure the immune response in up to 150 children at St. Jude Children's Research Hospital. The goal is to see if the vaccine triggers enough prote…

This study looks at how well leg muscles produce energy in older adults (60+) with and without HIV. Researchers will use MRI scans and walking tests to measure muscle metabolism and fatigue. The goal is to understand if metabolic problems in the calf muscle are linked to reduced …

This study is testing a new rapid diagnostic device called In-Dx to quickly identify infections and antibiotic resistance in emergency patients with suspected sepsis. Researchers will compare the device's results to standard lab cultures using stored samples from 2,500 patients. …

This study looks at how well the shingles vaccine (Shingrix) works in people with lupus compared to healthy people of the same age and sex. Researchers will measure immune cell responses after two doses and follow participants for up to 5 years. The goal is to understand if the v…

This study analyzes dried blood spots from 630 newborns to find protein and RNA markers that could predict which babies with congenital CMV will develop hearing loss or other problems. Researchers will compare samples from infected babies who had complications, those who did not,…

This study looks at why some people had severe COVID-19 while others had mild symptoms. Researchers will compare the immune system's early response (called interferon) in 134 adults who were sick during the first wave. They also want to see if gut bacteria play a role. The goal i…

This study collects blood, urine, bone marrow, and tumor samples from people with hairy cell leukemia and other blood cancers, as well as from healthy volunteers. Researchers will use these samples to study the diseases and develop new treatments called immunotoxins, which use an…

This study recruits 500 people who inject drugs through social media to see if they can use at-home HIV test kits mailed to them. Participants fill out online surveys and mail back samples. The goal is to find out if this approach is a practical way to conduct HIV prevention rese…

This study collects blood plasma and white blood cells from healthy volunteers and people with HIV using a procedure called apheresis. The samples are used for laboratory research on infectious diseases and immune function. Up to 3,000 participants aged 18 and older will be enrol…

This study aims to find out whether people with long COVID still have inactive remnants of the SARS-CoV-2 virus in their bodies. Researchers will collect tissue samples from 12 adults who have recovered from COVID-19, some with long COVID symptoms and some without. The goal is to…

This study looks at why oral rotavirus vaccines are less effective in some low-income countries like Zambia. Researchers will collect blood, stool, and tissue samples from 43 adults to study how gut health and the immune system affect vaccine response. The goal is to find biologi…

This study will screen 2,000 people with HIV for fatty liver disease using a painless ultrasound technique. The goal is to catch liver problems early and improve long-term care. Researchers will also track how different HIV medications affect liver health.

This study looks at why some people with HIV develop Immune Reconstitution Inflammatory Syndrome (IRIS) after starting HIV medications. Researchers will use PET scans and lymph node biopsies to track inflammation and immune recovery in 300 adults. The goal is to better understand…

This study looks at whether a prebiotic supplement can help repair the gut barrier and reduce inflammation in people with HIV who also have alcohol use disorder. Forty participants will take either a prebiotic or a placebo for four weeks, then switch. Researchers will measure gut…

This study collects blood and tissue samples from 200 adults with HIV and certain cancers (like Kaposi sarcoma, lymphoma, or anal cancer) to help researchers understand how HIV and cancer are connected. Participants donate samples, which are stored for future research. There is n…

This study aims to find genetic mutations that cause chronic active Epstein-Barr virus (CAEBV), a rare and serious disease mainly affecting children and young adults. Researchers will analyze blood and tissue samples from up to 50 patients and 150 relatives, plus anonymous donor …

This study follows 150 adults with Kaposi sarcoma (KS) for up to 10 years to learn how the disease behaves, why it comes back, and how it affects the immune system and organs. Participants will have regular check-ups, scans, and biopsies, but no new treatments are being tested. T…

This study looks at how your immune system reacts when you get the flu. Researchers want to see if your body mostly uses memories from past flu infections or builds a brand new defense. About 50 adults with a confirmed flu will provide blood and nasal samples to help answer this …

This study looks at how the COVID-19 pandemic impacted the emotional, financial, physical, and social well-being of adolescent and young adult (AYA) cancer patients and survivors. Researchers will survey 600 participants to measure COVID-related distress and changes in health beh…

This study collects white blood cells from HIV patients through a process called leukapheresis to examine how the immune system responds to early treatment. Researchers aim to enroll 60 adults—30 with early HIV and 30 with chronic HIV—who are not yet on antiretroviral therapy. Pa…

This study looks at whether inflammation in the brain causes symptoms like loss of interest and slow movement in depressed people with HIV. Sixty participants will receive either the anti-inflammatory drug baricitinib or a placebo for 10 weeks. Researchers will use brain scans an…

This study looks at whether being more forgiving and holding less resentment can improve quality of life for people living with HIV. Researchers will follow 206 participants at a French hospital, measuring their tendency to forgive and their well-being. The goal is to see if forg…

This observational study will follow 2,500 people aged 14–55 who are at risk for HIV across multiple countries. Researchers will track how many new HIV and other sexually transmitted infections occur over time. The goal is to gather data that could help design future studies aime…

This study in Malawi aims to understand why COVID-19 was much less severe there than in Europe and the Americas. Researchers will follow 1500 people, including those infected and their household contacts, to see how factors like prior infections, nutrition, and immune responses a…

This study tests a program to help people safely stop taking long-acting injectable HIV prevention (PrEP). It will enroll 30 HIV-negative adults who are considering stopping or have stopped their PrEP shots. The program includes personalized coaching and, for some, monthly drug l…

This study in Zambia will follow about 11,800 people with advanced HIV who are starting or restarting antiretroviral therapy (ART). Researchers want to learn who these patients are, what challenges they face, and how well they do in the first six months of treatment. The goal is …

This study looks at 100 kidney transplant patients to understand where the BK virus comes from and why some people get sicker than others. Researchers will compare the virus in patients and their donors, and check how the immune system responds. The goal is to find better ways to…

This study looks at how viruses change the environment around tumors in people with lymphoma, lung cancer, or anal cancer. Researchers will analyze blood and tumor samples from 254 patients to understand why some cancers resist treatment. The goal is to find new ways to make anti…

This observational study follows 350 adults with blood cancers like lymphoma or multiple myeloma who are being treated with bispecific antibodies. Researchers will track how often infections occur, how severe they are, and what factors raise infection risk. The goal is to better …

This study is creating a large collection of blood samples and health data from 3500 people with hepatitis B, including those who have already cleared the virus. Researchers will use these samples to look for viral RNA patterns that could signal a functional cure. No new treatmen…

This study is creating a large database of health information from 743 adults with HIV/AIDS across Brazil. Researchers will look at how common chronic diseases like heart disease, kidney disease, and cancer are in this group. The goal is to gather data to help improve health poli…

This study is looking at 1,000 liver transplant recipients to see if testing their blood, urine, and tissue samples can detect early signs of chronic kidney disease, acute rejection, or hepatitis C. The goal is to find simple biomarkers that could lead to earlier treatment and fe…

This study looks at 60 adult male smokers under 65 who have both heart disease (acute coronary syndrome) and pneumonia along with COPD. Researchers want to see if certain blood markers (GDF-15, MR proADM, and Presepsin) change after getting a flu shot. The goal is to understand h…

This study looks at why some teenagers and young adults feel tired for months after getting Epstein-Barr virus (the virus that causes mono). Researchers will follow 150 infected people and 150 healthy people for six months, using brain scans, immune tests, and questionnaires. The…

This study collects anonymous symptom descriptions from 1,000 adults through an online platform. An AI tool then searches medical literature to see if it can find reliable biological signals in the free-text descriptions. The goal is to test how accurate and consistent the AI's f…

This study will follow 10,000 people in Australia who have chronic hepatitis B to see how well they are connected to care and treatment. Researchers will collect information from clinics across the country to understand who is getting treated and what their health needs are. No n…

This study is a registry that collects medical information from 1,000 COVID-19 patients treated at San Matteo Hospital in Italy. Researchers will analyze the data to find patterns linked to death during hospitalization. No new drug or treatment is being tested; the goal is to lea…

This study is creating a large database of information and tissue samples from 1,000 people with T-cell lymphoma. Researchers will use this data to learn more about the disease and how to improve patient outcomes. Participants provide medical information and optional blood and na…

This study looks at genetic changes in natural killer (NK) and B cells—key immune cells—in people with chronic hepatitis B. Researchers want to understand why these cells don't work properly during long-term infection. The study will analyze blood samples from 140 adults with chr…

This study gives a single dose of kisspeptin, a natural hormone, to 40 people with and without Long COVID. Researchers will take frequent blood samples to measure how the brain's reproductive hormone system responds. The goal is to understand if Long COVID disrupts this system, w…

This study collects blood and nasal secretions from up to 2,000 people with COVID-19 to learn why some get very sick while others recover easily. Researchers will also track long-term symptoms like fatigue and brain fog. No treatments are tested—the goal is to gather data to guid…

This study is testing a program to help more people in coastal Alabama get tested for HIV, quickly connect to care, and start treatment right away. The program uses data to find areas with high need, helps people link to care when diagnosed, and offers rapid antiretroviral therap…

This study examines the clinical and socioeconomic factors linked to suicidal behavior in children and adolescents during the COVID-19 pandemic in the Auvergne-Rhône-Alpes region of France. Researchers will collect data from 6,500 participants aged 8 to 17, including medical reco…

This study follows 390 adults in Zambia with hepatitis B, some also with HIV, to see how their liver and immune system change over time. Participants join when diagnosed or starting standard antiviral treatment and are monitored for years. The goal is to learn more about the dise…

This pilot study from Colorado State University will test 20 healthy adults (ages 18-40) to see if cold temperatures change how the body burns fat during exercise, and whether that change differs between females and males. Participants will exercise in both a normal room and a ve…

This study looks at whether getting a flu shot in the morning or evening makes a difference for people with chronic kidney disease. Researchers will measure antibody levels four weeks after vaccination to see which time works better. The study involves 735 adults with advanced ki…

This study looks at whether having a respiratory infection in the past changes how your lungs react to ozone, a common air pollutant. One hundred healthy adults will breathe ozone while exercising and have their lung cells sampled. The goal is to understand why some people may be…

This study looks at whether people with chronic hepatitis B who have undetectable virus levels in their blood also have undetectable levels in other body fluids like saliva or semen. Researchers will compare treated patients with suppressed virus to untreated patients with active…

This study at Johns Hopkins Hospital is looking at how COVID-19 infection and mRNA vaccines (Pfizer or Moderna) affect pregnant women and their newborns. Researchers will collect blood, placenta, and breast milk samples from 300 participants to study immune responses and pregnanc…

This study aims to collect blood and saliva samples from 2000 adults who come to the emergency room with a suspected respiratory infection. Researchers will use these samples to better understand how the body responds to infections and to find new ways to diagnose and treat them.…

This study uses a special PET-CT scan to track immune cells in people who have recovered from COVID-19. Up to 80 adults who had COVID-19 will get a tiny dose of a tracer to see where immune cells are active in their bodies. The goal is to learn more about how the immune system re…

This study is collecting medical information and biological samples from up to 6,000 people with COVID-19. Researchers want to find out which factors predict severe illness, death, or response to treatment. The goal is to better understand the disease and help guide future care.

This study looks at how serious respiratory infections (like flu, COVID-19, and RSV) affect the ability of adults aged 60 and older to live independently. Researchers will follow 1,600 hospitalized seniors across multiple countries to track changes in daily activities such as bat…

This study aims to understand why the protection from vaccines like those for COVID-19 fades over time. Researchers will follow 1,200 healthy adults for one year, collecting blood samples and health updates after they receive a vaccine or booster in their community. The goal is t…

This study aims to understand why some people continue to have symptoms like shortness of breath and fatigue long after a severe COVID-19 infection. Researchers will follow 67 adults for up to 12 months, using scans, blood tests, and other measures to look for clues in the lungs …

This study is creating a registry of 600 children under 18 with meningitis treated at hospitals across Brazil. Researchers will collect data during and after hospitalization to see how well current treatments work and what long-term problems, like hearing loss, occur. The goal is…

This study tests a method called SAIA to help family planning clinics in Kenya better offer HIV testing, treatment, and prevention services. About 40 clinics will either use SAIA or continue their usual routines. The goal is to see if this approach increases the number of women a…

This study looks at how the COVID-19 pandemic impacted out-of-pocket costs, lost wages, and unemployment for 600 breast cancer patients undergoing surgery. Participants will fill out questionnaires about their financial experiences. The goal is to understand the financial toxicit…

This study tests whether offering rapid point-of-care testing for gonorrhea and chlamydia helps more teens get HIV testing and PrEP. About 6,460 adolescents aged 16-24 will be compared: some get rapid testing, others get standard lab testing. The goal is to see if same-day result…

This study looks at whether stopping vaginal washing can lower inflammation in the cervix, which might help explain why this practice is linked to a higher risk of HIV. Researchers will measure immune cells and protective bacteria in 122 women who currently wash inside the vagina…

This study looks at the bacteria living in the lungs of people with active tuberculosis (TB) and how they change with treatment. Researchers will compare lung bacteria in diseased and healthy areas, and also check the mouth, nose, and gut. They aim to understand how these microbe…

This study aims to understand why some people lose their sense of smell after a COVID-19 infection and why it doesn't come back. Researchers will collect tiny tissue samples from the nose of 240 people—some with smell problems and some without—to look for differences in cells, in…

This study looks at anal cancer risk in men who have sex with men (MSM) who take PrEP to prevent HIV. Researchers want to find out how common high-grade anal lesions are, how well anal swabs detect them, and how these lesions affect quality of life. About 296 participants will an…

This study tests whether a web-based educational program can improve pregnant women's knowledge about influenza and Tdap vaccines and increase their intention to get vaccinated. Researchers will compare the program to standard antenatal care in 351 pregnant women in Malaysia. Par…

This study is a large international registry that will collect health information from 10,000 adults hospitalized with COVID-19. Researchers will track serious outcomes like death, heart failure, and kidney problems. The goal is to learn more about the course of the disease and i…

This study collects large amounts of blood cells from people with HIV to help researchers understand why the virus persists even with treatment. It involves up to 100 participants who are either on HIV therapy, elite controllers, or untreated with detectable virus. The goal is to…

This study looks at how CBD and THC, two compounds found in cannabis, affect inflammation and brain health in people with HIV. About 90 participants will take both substances in a random order over six weeks. Researchers will measure blood markers and brain function to better und…

This study looks at how cannabis ingredients (THC and CBD) affect decision-making, attention, and motivation in people with and without HIV. About 138 adults who use cannabis infrequently will take either THC, CBD, or a placebo for 5 days and complete thinking tests and brain flu…

This study takes small samples of lymph nodes from people with HIV to learn how the virus persists even with effective medication. Researchers want to measure how much HIV remains in these tissues and how much damage has occurred. The goal is to better understand why HIV is so ha…

This study looks at how to help people with both HIV and cancer stay engaged in their HIV care while receiving cancer treatment. Researchers will first observe 150 patients to identify barriers, then develop and test strategies to improve care. A second group of 150 patients will…