Monthly HIV prevention pill could replace daily dose
NCT ID NCT07071623
First seen Jun 24, 2026 · Last updated Jun 30, 2026 · Updated 4 times
Summary
This phase 3 trial tests MK-8527, a once-monthly oral pill, to prevent HIV-1 infection in women. About 4580 HIV-negative women will take either MK-8527 monthly or a daily PrEP pill (Truvada) to see which works better and is safer. The goal is to offer a more convenient prevention option.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
MK-8527 (oral tablet)
What this could lead to
If successful, this could offer a more convenient once-monthly pill for HIV prevention, potentially improving adherence and reducing infection rates.
What could go wrong
This is a phase 3 trial, but results may show MK-8527 is less effective or has more side effects than daily PrEP. Long-term safety and real-world effectiveness are still unknown.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Africa Health Research Institute (AHRI) - Mtubatuba ( Site 0049)
RECRUITINGSomkhele - Mtubatuba, KwaZulu-Natal, 3935, South Africa
Contact Phone: •••-•••-••••
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CAPRISA Vulindlela Clinical Research Site ( Site 0029)
RECRUITINGPietermaritzburg, KwaZulu-Natal, 3231, South Africa
Contact Phone: •••-•••-••••
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CAPRISA eThekwini Clinical Research Site ( Site 0030)
RECRUITINGDurban, KwaZulu-Natal, 4001, South Africa
Contact Phone: •••-•••-••••
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DTHF Masiphumelele Clinical Research Site ( Site 0023)
RECRUITINGCape Town, Western Cape, 7795, South Africa
Contact Phone: •••-•••-••••
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Desmond Tutu Health Foundation. Philippi Village ( Site 0024)
RECRUITINGCape Town, Western Cape, 7781, South Africa
Contact Phone: •••-•••-••••
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Foundation For Professional Development ( Site 0031)
RECRUITINGNdevana, Eastern Cape, 5660, South Africa
Contact Phone: •••-•••-••••
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Helen Joseph Hospital-Clinical HIV Research Unit ( Site 0048)
RECRUITINGJohannesburg, Gauteng, 2092, South Africa
Contact Phone: •••-•••-••••
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Infectious Diseases Institute Kalangala ( Site 0063)
RECRUITINGKalangala District, Kalangala, 30060/+256, Uganda
Contact Phone: •••-•••-••••
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Josha Research ( Site 0045)
RECRUITINGBloemfontein, Free State, 9301, South Africa
Contact Phone: •••-•••-••••
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KEMRI-CMR-RCTP ( Site 0003)
RECRUITINGNairobi, Kisumu County, 00200, Kenya
Contact Phone: •••-•••-••••
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Kargeno Research & Policy Hub ( Site 0007)
RECRUITINGKisumu, 40123, Kenya
Contact Phone: •••-•••-••••
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MRC/UVRI and LSHTM Uganda Research Unit Masaka ( Site 0064)
RECRUITINGEntebbe, Central Region, 256, Uganda
Contact Phone: •••-•••-••••
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MU-JHU Research Collaboration - Kampala ( Site 0062)
RECRUITINGKampala, 10216/+256, Uganda
Contact Phone: •••-•••-••••
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MU-JHU Research Collaboration - Mityana ( Site 0061)
RECRUITINGMityana, District, Mityana, 30026/+256, Uganda
Contact Phone: •••-•••-••••
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Partners in Health and Research Development (PHRD) ( Site 0002)
RECRUITINGThika, Kiambu County, 00202, Kenya
Contact Phone: •••-•••-••••
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Perinatal HIV Research Unit (PHRU) ( Site 0033)
RECRUITINGJohnnesburg, Gauteng, 1864, South Africa
Contact Phone: •••-•••-••••
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Qhakaza Mbokodo Research Clinic ( Site 0028)
RECRUITINGLadysmith, KwaZulu-Natal, 3370, South Africa
Contact Phone: •••-•••-••••
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SA Medical Research Council - Botha's Hill Clinical Research Site ( Site 0035)
RECRUITINGDurban, KwaZulu-Natal, 3660, South Africa
Contact Phone: •••-•••-••••
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SA Medical Research Council - Chatsworth Clinical Research Site ( Site 0026)
RECRUITINGChatsworth, KwaZulu-Natal, 4092, South Africa
Contact Phone: •••-•••-••••
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SA Medical Research Council - Phoenix Clinical Research Site ( Site 0037)
RECRUITINGPhoenix, KwaZulu-Natal, 4068, South Africa
Contact Phone: •••-•••-••••
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SA Medical Research Council - Verulam Clinical Research Site ( Site 0036)
RECRUITINGVerulam, KwaZulu-Natal, 4340, South Africa
Contact Phone: •••-•••-••••
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SYNAPSE Research Clinic ( Site 0043)
RECRUITINGEdendale, KwaZulu-Natal, 3216, South Africa
Contact Phone: •••-•••-••••
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Setshaba Research Centre ( Site 0032)
RECRUITINGPretoria, Gauteng, 0152, South Africa
Contact Phone: •••-•••-••••
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Synergy Biomed Research Institute ( Site 0040)
RECRUITINGEast London, Eastern Cape, 5241, South Africa
Contact Phone: •••-•••-••••
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UVRI Clinical Research Program Initiative Ltd (UVRI CRP) ( Site 0067)
RECRUITINGEntebbe, Wakiso, 30006, Uganda
Contact Phone: •••-•••-••••
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UW - KNH; Rachuonyo County Hospital ( Site 0006)
RECRUITINGHomabay County, Homa Bay County, 40222, Kenya
Contact Phone: •••-•••-••••
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Umlazi Clinical Research Site ( Site 0047)
RECRUITINGDurban, KwaZulu-Natal, 4089, South Africa
Contact Phone: •••-•••-••••
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Vuka Research Clinic ( Site 0025)
RECRUITINGKhayelitsha, Western Cape, 7784, South Africa
Contact Phone: •••-•••-••••
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Wits Maternal Adolescent and Child Health Research Unit (WMRU) ( Site 0027)
RECRUITINGDurban, KwaZulu-Natal, 4001, South Africa
Contact Phone: •••-•••-••••
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Wits RHI Ward 21 Clinical Research site ( Site 0022)
RECRUITINGJohannesburg, Gauteng, 2001, South Africa
Contact Phone: •••-•••-••••