Could a prebiotic soothe the gut in HIV and alcohol use?

NCT ID NCT06139224

Recruiting now Knowledge-focused Sponsor: Rush University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether a prebiotic supplement can help repair the gut barrier and reduce inflammation in people with HIV who also have alcohol use disorder. Forty participants will take either a prebiotic or a placebo for four weeks, then switch. Researchers will measure gut health, inflammation, and immune markers to understand the link between gut bacteria and HIV-related complications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: prebiotic (short-chain fatty acid prebiotic powder)
What this could lead to: If successful, this could point toward a simple dietary supplement to reduce inflammation and improve gut health in people living with HIV.
What could go wrong: This is a small, early proof-of-concept study (40 people) with a short 8-week duration. Results may not apply to broader populations or lead to a treatment.

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Conditions

The condition(s) this trial relates to.

AIDS alcohol abuse HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALCOHOL USE DISORDER HUMAN IMMUNODEFICIENCY VIRUS

Contacts and locations

Locations

Ali Keshavarzian
RECRUITING

Chicago, Illinois, 60612, United States

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