HUMAN IMMUNODEFICIENCY VIRUS

This early-stage trial tests a therapeutic DNA vaccine called ICVAX in 22 adults with HIV who are stable on antiretroviral therapy (ART). The goal is to see if the vaccine is safe and can boost the body's immune response against HIV. Participants receive four vaccine injections o…

This early-stage study tests whether a new vaccination schedule for an experimental HIV vaccine is safe and triggers an immune response. Healthy adults aged 18-50 will receive either the vaccine or a placebo. The goal is to find a better way to protect against HIV.

This study looks at whether two doses of the HPV vaccine can protect women living with HIV as well as the standard three doses. Researchers will enroll 275 women across Canada and compare immune responses over two years. If successful, fewer doses could make HPV vaccination cheap…

This study tests whether baricitinib, an FDA-approved arthritis pill, can lower the amount of HIV hiding in the brain. Even when standard HIV therapy keeps the virus low in the blood, it can persist in the central nervous system. About 95 adults with well-controlled HIV will rece…

This study tests whether specially grown donor immune cells (called cytotoxic T lymphocytes) can safely and effectively treat BK and JC virus infections in 100 people with cancer, HIV/AIDS, or organ transplants. These viruses can cause serious problems like kidney damage or brain…

This study tests whether adding the drug lenacapavir to standard HIV treatment can reduce the hidden HIV reservoirs that remain in the body. About 50 adults with well-controlled HIV will either add lenacapavir or continue their usual therapy. Researchers will measure changes in t…

This study looks at whether a team-based mental health program can help pregnant and new mothers living with HIV in Kenya feel better and stay healthy. About 900 women will receive extra mental health support alongside their regular HIV care. The goal is to reduce depression and …

This study compares two antibiotics for treating early syphilis: an oral pill (cefixime) versus a standard shot (penicillin). About 400 adults with early-stage syphilis, including those with well-controlled HIV, will take part. The goal is to see if the pill works as well as the …

This study tests a program to help people with HIV stick to their medication. Participants will either join an adherence club where they pick up 6 months of medicine and get peer support, or receive standard care. The goal is to see if the program improves viral suppression and k…

This study tests whether kidney transplants from HIV-positive donors are safe and effective for people with HIV who also have kidney failure. About 30 adults with well-controlled HIV will receive a kidney from an HIV-positive donor. Researchers will track survival and kidney func…

This study tests whether a low dose of naltrexone (LDN) can reduce chronic nerve pain in people with HIV. About 60 adults with HIV and neuropathic pain will take LDN for 12 weeks while researchers track pain scores and CD4 counts. The goal is to find a safer, non-opioid option fo…

This study is testing a program called PRISM that teaches stress management skills to teenagers (ages 10-19) living with HIV in Eswatini. The goal is to see if the program is practical, liked by participants, and helps reduce psychological distress while improving resilience and …

This study looks at whether harm reduction care—where healthcare providers focus on reducing harm rather than judging drug use—can improve health outcomes and reduce stigma for people living with HIV who use drugs. Researchers will study about 768 patients and their providers at …

This study aims to see how many people visiting emergency departments in South Africa have HIV or are at high risk of getting it. Researchers will offer HIV tests to all patients and connect those who test positive to long-term care, while also referring those at risk to a preven…

This study aims to learn more about the biology of cancers linked to viruses or immune problems like HIV. Researchers will collect tissue and blood samples from 280 adults to compare genes in cancer cells versus normal cells. The goal is to find genetic variations that could lead…