HUMAN IMMUNODEFICIENCY VIRUS

This is an early safety study testing two different schedules for an experimental HIV vaccine combination in healthy adults. The main goal is to see if the vaccines are safe and if they trigger an immune response. Researchers will compare a standard dosing schedule to a faster, e…

This study is testing if adding a new drug called lenacapavir to standard HIV medication can reduce the hidden, inactive virus that persists in the body. It will involve 50 adults whose HIV is already well-controlled with long-term therapy. Researchers will compare the size of th…

This study aims to learn about the safety and effectiveness of kidney transplants from donors with HIV to recipients who also have HIV. Researchers will follow 30 HIV-positive adults who need a kidney transplant and receive one from an HIV-positive donor. The goal is to gather kn…

This study is testing if baricitinib, an existing drug for rheumatoid arthritis, can reduce the amount of hidden HIV virus in the brain and spinal fluid. It involves 95 adults whose HIV is well-controlled with standard medication. Researchers will compare the drug to a placebo, u…

This study is testing a new cell therapy for people with serious BK or JC virus infections. These viruses can cause severe problems in people with weakened immune systems, such as those with cancer, HIV, or a transplant. Doctors take virus-fighting immune cells from a donor, grow…

This study is testing a new support program to help people with HIV stay on their medication. It will compare a 'club' model—where participants pick up 6 months of medicine and get peer support—to standard clinic visits. The main goal is to see if this approach helps people maint…

This study aims to see if busy hospital emergency rooms can be used to find people at high risk for HIV and connect them to prevention services. Researchers will offer HIV testing and information about prevention drugs (PrEP) to all eligible patients in emergency departments in S…

This study is testing whether two doses of the HPV vaccine work as well as the standard three doses for women living with HIV. The goal is to prevent HPV infection and the cervical cancer it can cause. Researchers will compare the immune response in women who get two shots versus…

This study is testing a short counseling program designed to help teens living with HIV manage stress and build resilience. Researchers in Eswatini will enroll 140 adolescents to see if the program is practical, acceptable, and can improve their mental well-being and quality of l…

This study aims to understand the genetic makeup of cancers that occur in people with viral infections, HIV, or immune system disorders like Castleman disease. Researchers will collect and analyze tissue samples from adult participants to look for genetic changes that might expla…