Scientists hunt for genetic clues in Virus-Linked cancers

NCT ID NCT03300830

Recruiting now Knowledge-focused Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 3 times

Summary

This study collects tissue and blood samples from adults with HIV, other immune disorders, or cancers thought to be caused by viruses. Researchers will compare genes in cancer tissue to normal tissue to find genetic changes that drive these cancers. The goal is to better understand the biology of these tumors, which could lead to improved prevention, detection, and treatment in the future.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could reveal genetic clues that lead to better ways to prevent, detect, or treat cancers linked to viruses or immune problems.
What could go wrong: This is an observational tissue-collection study, not a treatment trial. It may not directly benefit participants, and results may take years to translate into clinical advances.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

AIDS Castleman disease HIV infectious disease HIV-associated cancer human herpesvirus 8-related tumor idiopathic multicentric Castleman disease inborn error of immunity Kaposi's sarcoma virus associated tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CASTLEMAN'S DISEASE HUMAN IMMUNODEFICIENCY VIRUS KAPOSI'S SARCOMA VIRAL-ASSOCIATED CANCER

Contacts and locations

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

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