Could a tiny dose of naltrexone ease HIV nerve pain without opioids?

NCT ID NCT05537935

Recruiting now Symptom relief Sponsor: Emory University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a low dose of naltrexone, a drug normally used for addiction, can safely reduce chronic nerve pain in people with HIV. About 60 adults with HIV and nerve pain will take the drug for 12 weeks and report their pain levels. The goal is to find a cheaper, non-opioid option for pain relief and possibly improve immune function.

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Conditions

The condition(s) this trial relates to.

AIDS HIV infectious disease Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC NEUROPATHIC PAIN HUMAN IMMUNODEFICIENCY VIRUS

Contacts and locations

Locations

Emory Midtown Hospital
RECRUITING

Atlanta, Georgia, 30308, United States
Emory University Hospital
RECRUITING

Atlanta, Georgia, 30322, United States
Grady Memorial Hospital
RECRUITING

Atlanta, Georgia, 30303, United States

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