Could a pill replace the shot for syphilis?

NCT ID NCT04958122

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two antibiotics for treating early syphilis: a single penicillin shot (standard care) versus a 14-day course of cefixime pills. Researchers want to see if the pill works just as well. The study includes 400 adults with early syphilis, including those with well-controlled HIV.

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Conditions

The condition(s) this trial relates to.

AIDS HIV infectious disease primary syphilis syphilis Treponema infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • University of Southern California

    RECRUITING

    Los Angeles, California, 90032, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••