Can an updated COVID-19 vaccine keep up with the virus?

NCT ID NCT07730450

Recruiting now ⭐️ VACCINE ⭐️ Sponsor: BioNTech SE Source: ClinicalTrials.gov ↗

First seen Jul 28, 2026 · Last updated Aug 07, 2026 · Updated 2 times

Summary

This trial is testing an updated version of the BNT162b2 COVID-19 vaccine in healthy adults aged 18 to 64. Participants will receive either the updated COVID-19 vaccine or a Tdap vaccine (for tetanus, diphtheria, and whooping cough) to compare safety and measure spike protein levels in the blood. The study aims to see how well the updated vaccine works and whether it is safe for seasonal use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: an updated RNA-based COVID-19 vaccine (BNT162b2) targeting a SARS-CoV-2 variant
What this could lead to: If successful, this could support the use of updated COVID-19 vaccines for seasonal protection in healthy adults.
What could go wrong: This is a phase 4 safety study with only 200 participants, so it may not detect rare side effects or fully predict real-world effectiveness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for COVID-19 VACCINES are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Coronavinae infectious disease Coronaviridae Infections Infections lung disorder Nidovirales infectious disease pneumonia respiratory system disorder respiratory tract infectious disorder RNA Virus Infections viral infectious disease viral pneumonia COVID-19 prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID-19 VACCINES

Contacts and locations

Locations

Diablo Clinical Research, LLC dba Flourish Research
RECRUITING

Walnut Creek, California, 94598, United States
Duke Vaccine and Trials Unit
RECRUITING

Durham, North Carolina, 27703, United States
East-West Medical Research Institute
RECRUITING

Honolulu, Hawaii, 96814, United States
J. Lewis Research, Inc. / Foothill Family Clinic
RECRUITING

Salt Lake City, Utah, 84109, United States
Palm Springs Community Health Center
RECRUITING

Miami Lakes, Florida, 33014, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.