One shot, two viruses: could a combined vaccine shield seniors from RSV and HMPV?

NCT ID NCT07734649

Recruiting now ⭐️ VACCINE ⭐️ Sponsor: Sanofi Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This trial is testing an experimental vaccine designed to protect against two respiratory viruses at once: RSV and HMPV. The study involves about 2,400 adults aged 60 and older, who will receive one of several dose levels of the vaccine, a placebo, or a control vaccine. Researchers are measuring how well the vaccine triggers an immune response and monitoring for side effects over 12 months. The goal is to see if a single shot can safely prevent illness from both viruses in older adults.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: an experimental bivalent vaccine targeting RSV and HMPV
What this could lead to: If successful, this could lead to a single vaccine that protects older adults against two common respiratory viruses, including HMPV for which no vaccine currently exists.
What could go wrong: This is an early-phase trial testing multiple dose levels, so the optimal dose and safety profile are not yet known. The vaccine may not produce strong enough immunity or could cause side effects.

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Conditions

The condition(s) this trial relates to.

respiratory syncytial virus infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY VOLUNTEERS HUMAN METAPNEUMOVIRUS IMMUNIZATION RESPIRATORY SYNCYTIAL VIRUS IMMUNIZATION

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Accel Research Sites - NeuroStudies- Site Number : 8400063
RECRUITING

Decatur, Georgia, 30030, United States
Accel Research Sites Network - DeLand Clinical Research Unit- Site Number : 8400064
RECRUITING

DeLand, Florida, 32720, United States
Alliance Clinical - Las Vegas- Site Number : 8400034
RECRUITING

Las Vegas, Nevada, 89109, United States
Alliance Clinical - San Diego- Site Number : 8400033
RECRUITING

San Diego, California, 92120, United States
Charlottesville Medical Research- Site Number : 8400062
RECRUITING

Charlottesville, Virginia, 22911, United States
Coastal Carolina Research Center - North Charleston- Site Number : 8400061
RECRUITING

North Charleston, South Carolina, 29405, United States
DM Clinical Research - Chicago- Site Number : 8400050
RECRUITING

Melrose Park, Illinois, 60160, United States
DM Clinical Research - Detroit- Site Number : 8400049
RECRUITING

Southfield, Michigan, 48076, United States
DM Clinical Research - Philadelphia- Site Number : 8400046
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
DM Clinical Research - Sugar Land- Site Number : 8400048
RECRUITING

Sugar Land, Texas, 77478, United States
DM Clinical Research - Tomball- Site Number : 8400045
RECRUITING

Tomball, Texas, 77375, United States
Hawthorne Health - Gadsden City Pharmacy- Site Number : 8400025
RECRUITING

Gadsden, Alabama, 35901, United States
Hawthorne Health - Staten Island- Site Number : 8400026
RECRUITING

Staten Island, New York, 10309, United States
Long Beach Research Institute- Site Number : 8400005
RECRUITING

Long Beach, California, 90805, United States
Scottsdale Clinical Trials- Site Number : 8400011
RECRUITING

Scottsdale, Arizona, 85260, United States
Velocity Clinical Research - Austin- Site Number : 8400013
RECRUITING

Austin, Texas, 78759, United States
Velocity Clinical Research - Lincoln - Valley Road- Site Number : 8400016
RECRUITING

Lincoln, Nebraska, 68510, United States

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