New vaccine aims to tame chronic hepatitis b without daily pills
NCT ID NCT06513286
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a therapeutic vaccine called TherVacB in 81 adults with chronic hepatitis B who are already on antiviral medication. The vaccine is given as a series of shots to boost the immune system and lower hepatitis B virus levels. The main goals are to check safety and see if the vaccine can reduce virus markers in the blood.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
TherVacB (HEPLISAV B with or without HBcoreAg plus MVA-HBVac)
What this could lead to
If successful, this could lead to a treatment that helps control chronic hepatitis B without lifelong antiviral pills.
What could go wrong
This is an early-phase trial with only 81 participants, so safety and immune response are still being tested. The vaccine may not lower virus levels enough or could cause liver side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Investigational Site GUF
RECRUITINGFrankfurt, 60590, Germany
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Investigational Site LMU
RECRUITINGMunich, 81337, Germany
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Investigational Site MHH
NOT_YET_RECRUITINGHanover, 30625, Germany
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Investigational Site TUM
RECRUITINGMunich, 81675, Germany
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Investigational Site UKE
RECRUITINGHamburg, 20246, Germany
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Investigational Site Uni Leipzig
RECRUITINGLeipzig, 04103, Germany