New vaccine aims to tame chronic hepatitis b without daily pills

NCT ID NCT06513286

Recruiting now Disease control Sponsor: Michael Hoelscher Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a therapeutic vaccine called TherVacB in 81 adults with chronic hepatitis B who are already on antiviral medication. The vaccine is given as a series of shots to boost the immune system and lower hepatitis B virus levels. The main goals are to check safety and see if the vaccine can reduce virus markers in the blood.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TherVacB (HEPLISAV B with or without HBcoreAg plus MVA-HBVac)
What this could lead to: If successful, this could lead to a treatment that helps control chronic hepatitis B without lifelong antiviral pills.
What could go wrong: This is an early-phase trial with only 81 participants, so safety and immune response are still being tested. The vaccine may not lower virus levels enough or could cause liver side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic hepatitis B virus infection hepatitis B virus infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC HEPATITIS B

Contacts and locations

Locations

Investigational Site GUF
RECRUITING

Frankfurt, 60590, Germany
Investigational Site LMU
RECRUITING

Munich, 81337, Germany
Investigational Site MHH
NOT_YET_RECRUITING

Hanover, 30625, Germany
Investigational Site TUM
RECRUITING

Munich, 81675, Germany
Investigational Site UKE
RECRUITING

Hamburg, 20246, Germany
Investigational Site Uni Leipzig
RECRUITING

Leipzig, 04103, Germany

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