CHRONIC HEPATITIS B

This study is testing whether a new injectable drug called HRS-5635, given alone or with other medications, can help control chronic hepatitis B. It will involve 369 adults who already have the virus under control with standard pills. Researchers will check if the new treatment c…

This large study is observing 15,000 adults with chronic hepatitis B across 200 hospitals in China. It aims to see which standard antiviral treatments work best in the real world to lower the risk of developing liver cancer and improve other health outcomes. The goal is to gather…

This 5-year study is testing if a common diabetes medication, dapagliflozin, can prevent serious liver complications like cancer and liver failure in people who have both chronic hepatitis B and diabetes. About 412 participants will be randomly assigned to take either the real dr…

This study is testing whether a combination of two injectable drugs can help control chronic Hepatitis B infection. It will involve about 50 adults with a mild or inactive form of the disease. Participants will receive monthly and weekly injections over six months, with the goal …

This study is testing an experimental injection called AHB-137 in people who already take standard pills for chronic hepatitis B. The goal is to see if the new treatment can further reduce the amount of virus in the blood and strengthen the body's immune response against it. Abou…

This study is observing if adding a specific gut bacteria (Bacteroides fragilis) and branched-chain amino acids (BCAA) to standard antiviral therapy helps the body clear the hepatitis B virus. Researchers will compare the clearance rate in 40 patients receiving this supplement to…

This study is testing whether azvudine tablets can provide long-term control of chronic hepatitis B. It will involve 120 participants who have not had prior antiviral treatment. Researchers will monitor virus levels, liver function, and immune response over 12 months to see if th…

This study is testing a new combination of drugs to try and achieve a 'functional cure' for chronic Hepatitis B, meaning the virus is undetectable and controlled by the immune system without ongoing medication. It will involve 120 adults with Hepatitis B who are already on standa…

This study aims to test the safety and effectiveness of a medication called tenofovir alafenamide (TAF) for children and teenagers with chronic hepatitis B. It will enroll 150 participants aged 2 to 18 years old. The main goal is to see if TAF can lower the amount of virus in the…

This large Phase 3 trial is testing whether adding a new drug called Neracorvir (GST-HG141) helps patients with chronic hepatitis B who still have detectable virus despite taking standard antiviral pills. The study will enroll over 500 adults who haven't responded well to their c…

This study is testing how a new drug called Imdusiran works inside the liver of people with chronic hepatitis B. Up to 10 participants already on standard antiviral pills will receive four injections of the drug over several months and undergo two liver biopsies to measure the dr…

This early-stage study is checking if a vaccine normally used to prevent hepatitis B is safe for people who already have a long-term infection. Researchers will give two vaccine shots to 10 adults whose infection is currently controlled with medication. The main goal is to see wh…

This is an early safety study for a new injection called SA1211. It aims to see if the shot is safe, how the body processes it, and if it shows any early signs of helping people with chronic hepatitis B. The study will involve 80 people, including healthy volunteers and those wit…

This large, real-world study aims to find out which antiviral treatments work best for adults with chronic hepatitis B over the long term. Researchers will follow 33,000 patients for up to 5 years to see which drug regimens are most effective at preventing liver cancer and helpin…

This study is testing a new two-drug combination to help people with chronic hepatitis B achieve a 'functional cure,' meaning the virus is controlled long-term without ongoing medication. It combines an immune-boosting antibody with an existing antiviral drug. The trial will enro…

This early-stage trial is testing a new drug called Tune-401 in adults with chronic hepatitis B. The main goal is to check if the drug is safe and how the body processes it. Researchers will also measure how it affects the hepatitis B virus in participants who are already taking …

This study is testing whether a special type of MRI scan, called magnetic resonance elastography (MRE), can accurately measure liver scarring (fibrosis) in people with chronic Hepatitis B. The goal is to find a better, non-invasive way to monitor the disease over time, potentiall…

This study is testing a newer hepatitis B medicine called TAF in pregnant women who have the virus. The main goal is to see if TAF is safe and effective at preventing the mother from passing hepatitis B to her baby during pregnancy and birth. Researchers will measure drug levels …