New combo aims to cure hepatitis b in over half of patients
NCT ID NCT05771402
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This phase 2 trial tests a combination of an anti-PD-1 antibody, interferon, and standard antiviral drugs in 120 adults with chronic hepatitis B. The goal is to boost the immune system to clear the virus and achieve a functional cure, where the virus stays under control without lifelong treatment. The study builds on earlier work that achieved cure in up to 50% of certain patients, and aims to improve that rate further.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Anti-PD-1 antibody, Peg-IFNα, and nucleos(t)ide analogues (ETV/TDF/TAF)
- What this could lead to
- If successful, this combination could help more than half of patients with chronic hepatitis B achieve a functional cure, meaning the virus is controlled without lifelong medication.
- What could go wrong
- This is a phase 2 trial with only 120 participants, so results are preliminary. The anti-PD-1 antibody may cause immune-related side effects, and the cure rate may not reach the hoped-for 50%.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
The 2nd affiliated Hospital of Chongqing Medical University
RECRUITINGChongqing, Chongqing Municipality, 400010, China
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Other studies related to the condition(s) this trial covers.
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