Viral infectious disease

This study tested whether offering hepatitis C (HCV) treatment right at methadone clinics helps more people get cured compared to sending them to outside specialists. Over 600 adults on opioid addiction therapy took part across 13 clinics in Ukraine. Some clinics provided simplif…

This study tests an RSV vaccine in pregnant women living with HIV. The goal is to see if the vaccine is safe and helps mothers pass protective antibodies to their babies, potentially preventing severe RSV lung infections in infants. The trial involves about 681 pregnant participa…

This study looks at children and teens with HIV to find the best number of HPV vaccine doses. Researchers are comparing one, two, or three doses to see if fewer shots can still provide strong protection against HPV. The goal is to simplify vaccination and improve health outcomes …

This study tests a hexavalent vaccine that protects against six diseases, including polio, but uses a lower dose of the inactivated polio vaccine (IPV). The goal is to see if this reduced-dose version works as well as the standard full-dose vaccine in infants. Around 1,500 health…

This phase 2b trial tests several versions of an experimental flu vaccine that includes an adjuvant (MF59) to strengthen the immune response. The vaccine is made from cells, not eggs, and targets four flu strains. Around 1,000 adults aged 50 and older receive a single shot and ar…

This phase 3 study tests whether three doses of an oral rotavirus vaccine (ROTAVAC 5D) can prevent severe diarrhea in healthy infants. Around 4,270 Chilean babies receive either the vaccine or a placebo. Researchers track cases of severe rotavirus gastroenteritis to measure the v…

This phase 3 trial tests a freeze-dried rabies vaccine in healthy Chinese volunteers aged 10 to 60. The study compares the new vaccine's ability to trigger protective antibodies and its safety against an existing rabies vaccine. Rabies is nearly always fatal once symptoms appear,…

This clinical trial tested a new vaccine designed to protect against two viruses (EV71 and CA16) that cause hand, foot, and mouth disease and herpangina. The study involved 744 healthy adults and children, including kids as young as 6 months. Researchers checked the vaccine's saf…

This early-stage trial tested a new COVID-19 booster vaccine, STX-S, in 60 healthy adults who had already received a primary vaccine series and at least one booster. The vaccine uses tiny particles called exosomes to deliver spike proteins. The main goal was to check safety and s…

This phase 3 study tested a single dose of an investigational RSV vaccine in 751 adults aged 60 and older, and those 50-59 at increased risk for severe RSV. The goal was to see how well the vaccine boosts the immune system and whether it is safe. Participants received either the …

This early-stage trial tested a new HIV vaccine candidate in 57 healthy adults without HIV. The goal was to see if the vaccine is safe and whether it triggers a specific immune response that could help fight the virus. Researchers used a special adjuvant to boost the vaccine's ef…

This early-stage trial is testing a new mRNA flu vaccine in 50 healthy adults aged 18 to 49. The vaccine uses mRNA technology to target a specific flu strain. Researchers will compare its safety and immune response to a standard seasonal flu shot. The goal is to see if the new va…

This early-stage trial tests a single dose of a new mRNA flu vaccine (VRC H1ssF-3928) in 50 healthy adults aged 18 to 49. The vaccine aims to teach the body to fight a stable part of the flu virus. Researchers are checking for side effects and measuring immune responses, comparin…

This study tested whether getting a different COVID-19 vaccine for the second shot (instead of the same one) is safe and boosts immunity. 100 healthy adults who had already received one dose of the AZD1222 vaccine were randomly assigned to get either the same vaccine or a differe…

This Phase 1 trial tested a new live-attenuated dengue vaccine in 127 healthy adults aged 18 to 59. The goal was to see how safe the vaccine is and how the immune system responds, especially in people who have had dengue before. Participants received one shot and were monitored f…

This study tested a new two-step vaccine approach to protect HIV-infected adults from pneumococcal infections, a common cause of serious illness in this group. The standard vaccine often doesn't work well in people with lower immune cell counts. The study involved 212 participant…

This phase 3 study tested the 9-valent HPV vaccine (Gardasil 9) in over 1,000 Japanese males aged 16 to 26. The goal was to see if the vaccine could prevent persistent HPV infections that can lead to genital warts and anal cancers. Participants received either the vaccine or a pl…

This study tested an mRNA vaccine (mRNA-1345) against respiratory syncytial virus (RSV) in 360 pregnant women. The goal was to see if the vaccine is safe for mothers and their babies, and whether it triggers an immune response that could protect infants after birth. Participants …

This early-stage study tests a new mRNA vaccine designed to protect against avian influenza (bird flu) in 80 healthy adults aged 18-49. The vaccine uses mRNA technology to teach the body to recognize and fight the H5 flu virus. The main goal is to check the vaccine's safety and s…

Pfizer completed a study testing a new modified RNA (mRNA) flu vaccine in 1,202 healthy adults aged 18 and older. The goal was to see if the vaccine is safe and triggers a strong immune response. Participants received either the experimental mRNA vaccine or a licensed flu shot, a…

This study looked at how well an inactivated EV71 vaccine protects children over 5 years after vaccination. It included 180 healthy kids who were first vaccinated between 2 months and 6 years old. Researchers measured antibody levels to see if protection lasted. The goal was to u…

This study tested an experimental RSV vaccine in adults who had a lung or kidney transplant, as well as in healthy adults over 50. The goal was to see if the vaccine could safely boost their immune response against RSV, a common and potentially serious respiratory virus. Research…

This study tested a new mRNA-based flu vaccine in over 1,100 adults aged 50 and older. The vaccine targets multiple flu virus proteins to potentially provide stronger protection. Researchers compared it to standard flu shots and monitored safety and immune response for six months…

This Phase 1 trial tested a new HIV vaccine in 68 healthy adults to see if it is safe and triggers an immune response. The vaccine uses a DNA-based approach combined with an HIV protein to train the body to fight the virus. While early results are encouraging, this is just the fi…

This early-stage trial tested whether a new herpes vaccine called HSV529 is safe for people. Researchers gave the vaccine or a placebo to 69 healthy adults aged 18 to 40, some of whom had herpes and some who did not. Participants received three shots over six months and were moni…

This large, final-stage study tested a new combination vaccine that aims to protect against both COVID-19 and the flu with a single shot. About 9,300 adults aged 65 and older took part, receiving either the combo vaccine or a standard high-dose flu vaccine. Researchers checked ho…

This study tested a single-dose chikungunya vaccine (VLA1553) in about 750 teenagers aged 12 to 17. The goal was to see if the vaccine safely produces enough antibodies to protect against the virus. Participants received either the vaccine or a placebo, and their immune responses…

This study tested a new vaccine designed to protect against the Omicron JN.1 variant of COVID-19. About 120 adults aged 65 and older, and teens and adults aged 12 to 64 with health conditions that increase COVID-19 risk, received one dose. Researchers checked how well the vaccine…

This study looks at whether an inactivated enterovirus 71 (EV71) vaccine still protects children two to two-and-a-half years after the last dose. It involves 126 healthy children from Vietnam who received the vaccine in an earlier phase 3 trial. Researchers will take a blood samp…

This early-stage trial tested a new two-part vaccine designed to treat chronic hepatitis B. It involved 26 healthy adults to check safety and immune response. The vaccine uses a protein first shot followed by a booster to teach the immune system to attack the virus.

This study tested an experimental mRNA vaccine (mRNA-1647) for cytomegalovirus (CMV) in healthy teens (9–15 years) and young women (16–25 years). The goal was to see if the vaccine is safe and triggers a strong immune response. Participants received either the vaccine or a placeb…

This study tested an updated RNA-based COVID-19 vaccine designed for the 2025-2026 season. It involved 774 participants aged 12 and older, including those 65+ and younger people with health conditions that raise their risk of severe COVID-19. Everyone received one shot, and resea…

This Phase 3 trial tested Takeda's dengue vaccine (TDV) in 480 healthy people aged 4 to 60 in India. Participants received two doses of either the vaccine or a placebo, three months apart. The main goals were to check for side effects and measure the body's immune response agains…

This large study tested the Pfizer-BioNTech COVID-19 vaccine in over 11,800 healthy children aged 6 months to 12 years. Researchers looked at side effects and immune responses after different doses. The goal was to find the right dose that is safe and triggers strong protection. …

This study tested new mRNA-based seasonal flu vaccines in 776 healthy adults aged 18 and older. The goal was to see how safe the vaccines are and how well they boost the immune system. Researchers measured side effects and immune responses to find the best vaccine candidate.

This early-stage study tested a new inactivated rotavirus vaccine (CDC-9) in 50 healthy adults aged 18 to 45. The goal was to see if the vaccine is safe and triggers an immune response. Participants received three shots over several months and were monitored for side effects and …

This study tested Novavax's COVID-19 vaccine in 3,600 children aged 6 months to 12 years. The goal was to see if the vaccine is safe and triggers a strong immune response. Children received two doses 21 days apart, with some getting a placebo. The trial is complete, and results w…

This study looked at whether the HPV vaccine works in girls aged 9 to 17 who are taking medicines that weaken their immune system, such as after an organ transplant or for diseases like lupus. The goal was to see if their bodies produce enough antibodies to protect against HPV. T…

This study tested two DNA vaccines designed to prevent hemorrhagic fever with renal syndrome caused by Hantaan and Puumala viruses. A total of 132 healthy adults received up to four doses of vaccine using a needle-free jet injector. The main goal was to see if the vaccines trigge…

This study tested an experimental RSV vaccine in adults aged 60 and older in China. The goal was to see if the vaccine produces a strong immune response similar to that seen in older adults from other countries, where the vaccine already proved effective. About 2,620 participants…

This completed Phase 3 trial tested whether an adjuvanted flu vaccine (FLUAD Quadrivalent) triggers a stronger immune response than a standard flu vaccine (FluQuadri) in 192 healthcare workers in Lima, Peru. Participants received one dose of either vaccine, and researchers measur…

This study tested whether a third dose of either the CoronaVac or Comirnaty vaccine boosts immunity better in adults who had two prior doses at least six months earlier. Researchers measured antibody levels in 451 participants from Hong Kong 28 days after the booster. The goal wa…

This study tested a new nasal spray vaccine for respiratory syncytial virus (RSV), a common cause of serious breathing problems in babies and young children. The vaccine was given as nose drops to 88 healthy children aged 4 months to 5 years, including those who had and had not b…

This study tested a vaccine called Triplex® in 94 adults who have both HIV and cytomegalovirus (CMV). The goal was to see if the vaccine is safe and helps the immune system control CMV. Participants received two shots of the vaccine or a placebo over 4 weeks and were followed for…

This study tested a booster vaccine for H5N6 bird flu in about 260 adults. Some had previously received an H5N1 bird flu vaccine, while others had not. The goal was to see if the booster was safe and triggered a strong immune response. Participants received one or two doses of th…

This study tested different ways to help teenagers complete the HPV vaccine series at community health centers serving low-income families. Researchers compared parent reminders (by mail and text), clinic system changes, and a combination of both against usual care. Over 17,000 t…

This completed Phase 4 trial tested whether the Butantan Institute's seasonal flu vaccine is as safe and effective as the Sanofi vaccine. A total of 632 Brazilian adults aged 18 to 69 received one of the two vaccines. Researchers measured immune response through blood tests and t…

This study tested an experimental vaccine called VBI-2901a in 103 healthy adults aged 18-64 who had already received at least two doses of a licensed COVID-19 vaccine. The vaccine is designed to protect against three coronaviruses: SARS-CoV-2 (which causes COVID-19), SARS-CoV-1, …

This study tested a single combination vaccine that aims to protect against both COVID-19 and influenza at the same time. About 980 adults aged 50 and older received either the combo shot, a flu shot alone, a COVID-19 shot alone, or both shots separately. Researchers monitored sa…

This study looked at how safe and effective two shingles vaccines (Zostavax and Shingrix) are in people with rheumatoid arthritis who are taking the drug abatacept. About 154 adults took part, and researchers measured their immune response and any side effects. The goal was to se…

This study tested an experimental mRNA vaccine called mRNA-1647 to see if it is safe and triggers an immune response against cytomegalovirus (CMV). The trial involved 315 healthy adults aged 18 to 40, some of whom had never been exposed to CMV. Researchers measured side effects a…

This study tested a single combination vaccine that targets both COVID-19 and influenza in adults aged 50 and older. About 980 participants received either the combo shot, the flu vaccine alone, the COVID-19 vaccine alone, or separate shots in each arm. Researchers monitored safe…

This study tested an experimental HIV vaccine in 132 healthy, HIV-negative adults. The vaccine uses a harmless virus (ALVAC) to deliver HIV proteins, plus a protein boost (gp120) with an adjuvant to strengthen the immune response. The main goals were to check safety and measure w…

This study tested an experimental HIV vaccine in 117 healthy, HIV-negative adults to see if it is safe and triggers an immune response. Participants received several injections of the vaccine or a placebo. The main goals were to check for side effects and measure antibody levels.…

This early-stage study tested six different mRNA vaccine formulations against respiratory syncytial virus (RSV) in 240 healthy adults aged 18 to 49. The goal was to check safety and how well the vaccines trigger an immune response. Each participant received a single shot and was …

This study tested updated versions of the Pfizer-BioNTech COVID-19 vaccine designed to target newer Omicron variants (XBB.1.5, JN.1, and KP.2). Over 1,000 healthy people aged 12 and older received a single dose. The main goals were to check safety and measure the immune response.…

This early-stage trial tested two new vaccines—one for yellow fever and one for rabies—in 112 healthy adults aged 18 to 40. The main goal was to check safety and see how well the vaccines trigger an immune response. Participants received different doses or a placebo to help find …

This study tested a new mRNA vaccine designed to protect against H5 pandemic flu strains. Researchers gave 276 healthy adults one of three doses or a placebo to check safety and immune response. The goal is to find the right dose for future studies.

This study tested the JYNNEOS smallpox vaccine in 1,600 healthcare workers in the Democratic Republic of the Congo who are at high risk of catching mpox. The goal was to see if the vaccine can prevent mpox infection and is safe to use. Participants received the vaccine and were m…

This study tests a mobile app designed specifically for Black adults living with HIV who smoke daily. The app includes culturally tailored content and anxiety-reduction techniques to support quitting. Participants are randomly assigned to use either the tailored app or a standard…

This study tests whether a synbiotic supplement (a mix of a prebiotic called 2'-FL HMO and a probiotic called B. infantis) can reduce infections and improve growth in infants who were exposed to HIV but are not infected themselves. About 140 infants will receive either the supple…

This study tested whether brief or in-depth counseling could help people living with HIV in Zambia reduce unhealthy alcohol use and improve HIV treatment. 680 adults who were on HIV medication and had hazardous drinking plus mental health or substance use issues took part. Partic…

This study tested two ways to offer HIV treatment, hepatitis C treatment, and substance use disorder medications to people who inject drugs. One group received a telehealth-enhanced program with on-demand services like mobile blood draws and counseling, while the other group got …

This study in Kenya tests different behavioral strategies to help 880 adolescents and young adults (ages 14-24) with HIV stay engaged in care. Participants first get either standard care or electronic navigation. If they miss appointments or have unsuppressed virus, they are re-r…

This study tests a program called Project YES+ for youth aged 15-21 living with HIV in Zambia. The program combines peer mentoring with mental health support to reduce stigma, violence, and depression. Researchers will enroll 400 participants to see if the program is feasible and…

This study tests a new way to help vulnerable people with HIV get diagnosed and start treatment right away using a mobile screening unit. Participants receive the once-daily pill Biktarvy on the same day they are enrolled. The goal is to see if this approach helps them stay in ca…

This study looked at whether starting antiretroviral therapy (ART) immediately (within 48 hours) versus waiting until an opportunistic infection is under control affects death rates in HIV/AIDS patients hospitalized with such infections. Researchers enrolled 114 adults with HIV a…

This study tests whether the immunotherapy drug durvalumab can be safely given to people with advanced liver cancer who also have an active hepatitis B infection. All participants receive an antiviral drug (entecavir) to control the hepatitis B virus. The main goal is to see if d…

This study tested a program called Gender-affirming Abriendo Puertas for transgender women living with HIV in Santo Domingo. The program included individual counseling, peer support, and community activities to help participants stay on HIV medication and achieve viral suppressio…

This study tested whether adding Naderin (sodium nucleinate) to standard treatment could reduce complications in 75 patients with cancer, tuberculosis, or hepatitis C. The main group received Naderin plus standard therapy, while the control group received standard therapy alone. …

This study looks at health records from about 99,000 adults in Ontario who had COVID-19 and visited a pharmacist. It compares those who got Paxlovid (nirmatrelvir-ritonavir) with those who didn't, to see if the drug lowers the chance of hospitalization, ICU admission, or death wi…

This trial tests a package of services called TASKPEN, which combines HIV care with screening and treatment for high blood pressure, diabetes, and tobacco use. It involves over 5,700 adults living with HIV in Lusaka, Zambia. The goal is to see if this integrated approach helps mo…

This study tests an experimental drug called SPI-1005 (ebselen) in adults hospitalized with severe COVID-19. Participants receive either the drug or a placebo to see if the drug is safe and helps improve recovery. The trial is randomized and double-blind, meaning neither patients…

This early-phase trial tested an experimental drug called BW-20507 in 32 people. First, healthy volunteers received a single dose to check safety. Then, people with chronic hepatitis B received multiple doses to see how the drug behaves in the body and whether it fights the virus…

This study tested two drugs, plerixafor and G-CSF, in 20 people with WHIM syndrome, a rare genetic condition that causes frequent infections and warts. Participants received each drug for a year and tracked their infections. The goal was to see which drug better reduced infection…

This study tested a program where HIV nurses were trained to also manage high blood pressure in people living with HIV. The goal was to see if this approach could lower blood pressure over 12 months. The study involved 830 adults at 30 primary health centers in Lagos, Nigeria.

This study tested the drug delamanid in 37 children with multidrug-resistant tuberculosis (MDR-TB), some of whom also had HIV. The goal was to see how the drug works in the body, check for side effects, and find the right dose. Children took delamanid along with their regular TB …

This study tests a new experimental drug, MK-4646, in people with HIV who have never taken HIV medications. The main goals are to see if the drug is safe and tolerable, and how much it can lower the amount of HIV in the blood. About 28 participants will receive the drug and be mo…

This study tests whether hearts from donors with hepatitis C can be safely transplanted into people without the virus. Twenty adults with end-stage heart failure on the transplant waiting list will receive these hearts and take antiviral medication to prevent infection. The goal …

This study investigates whether respiratory muscle training and walking exercises can improve lung function, reduce breathlessness, and enhance quality of life in women who have recovered from COVID-19 pneumonia. Eighty women aged 20 to 45 are divided into four groups: a combinat…

This trial tests a smartphone app called Tappt that uses smart tags to help people with hepatitis C stick to their daily oral medication. Participants scan tags each time they take a dose, and the app tracks adherence. The study compares their results to historical data from simi…

This small pilot study tested whether giving spironolactone, a drug normally used for heart conditions, could help people with HIV reduce their alcohol use. Twenty-one participants received the drug along with support from a pharmacist and psychiatrist. The study focused on wheth…

This study tests a combination of three HIV drugs (amprenavir, lopinavir, and ritonavir) in patients whose current treatments are no longer working. The goal is to see if this new mix can lower the amount of HIV in the blood over 26 weeks. Participants are HIV-positive adults who…

This trial investigates whether famotidine, the active ingredient in Pepcid, can help relieve COVID-19 symptoms in adults who are not sick enough to be hospitalized. Participants receive either famotidine or a placebo, along with standard care, and report their symptoms remotely.…

This trial compares a once-daily combination of three HIV drugs (emtricitabine, didanosine, and efavirenz) to the standard multi-pill regimen containing a protease inhibitor. The goal is to see if the simpler daily pill works just as well at keeping the virus undetectable, while …

This study tested a once-daily combination of three HIV drugs (FTC, ddI, efavirenz) in 39 adults who had never taken HIV medication before. The goal was to see if this simpler, once-a-day pill routine worked well and had fewer side effects than older treatments. Participants had …

This study tested whether adding prazosin, a drug usually used for high blood pressure, to standard hepatitis C treatment could reduce liver scarring. 112 adults with chronic hepatitis C (genotype 1 or 4) and severe liver fibrosis took part. Researchers measured changes in liver …

This study tested whether an extract from papaya leaves (CPLE) can help people with dengue fever. 250 adults with confirmed dengue were given either CPLE capsules or a placebo for 5 days. The main goals were to see if the extract could raise platelet counts and reduce the risk of…

This study tested a new strategy: giving TB prevention medicine at the same time as TB testing to people with HIV starting or restarting antiretroviral therapy. The goal was to see if this approach gets more people on TB prevention quickly without missing active TB cases. The tri…

This study tested a new immunotherapy called Olvi-Vec, which uses a modified virus to attack cancer cells, in 46 patients with ovarian cancer that had come back or stopped responding to standard treatments. The goal was to see if the treatment was safe and could slow tumor growth…

This early-stage study tested a new treatment approach for adults with chronic hepatitis B or D. Twenty participants received two medications in sequence: P1101 (a type of interferon) followed by an anti-PD1 drug. The main goal was to check safety and tolerability, while also loo…

This study tested whether a mobile health unit that offers HIV prevention, treatment, and medication for opioid use disorder all in one place helps people who inject drugs stay on treatment. About 447 adults with opioid use disorder took part. The goal was to see if this approach…

This study tested a new oral drug called pritelivir against standard treatments (foscarnet, cidofovir, or imiquimod) for herpes infections that no longer respond to acyclovir. It involved 158 immunocompromised participants, such as those with HIV or organ transplants. The goal wa…

This study tested a combination of three drugs—Grazoprevir/Elbasvir, Sofosbuvir, and Ribavirin—in 26 adults with hepatitis C genotype 1 or 4 who had not been cured by previous treatments. The goal was to see if 16 or 24 weeks of this therapy could clear the virus. The main measur…

This study tested whether adding a virus-based immunotherapy (Pexa-Vec) to the standard drug sorafenib helps people with advanced liver cancer live longer. About 459 adults with advanced liver cancer who had not received prior treatment took part. The approach uses a modified vir…

This study gave HIV-1 patients continued access to the drug etravirine until they could switch to a local treatment. It included 180 people aged 2 and older who had already benefited from the drug in a previous trial. The main goal was to monitor safety while providing the medica…

This study tested two methods to help people living with HIV/AIDS in South Africa reduce their cigarette smoking: using e-cigarettes or nicotine replacement therapy (like patches), plus supportive text messages. 106 adults who smoked daily took part. The goal was to see if these …

This study tested a program called SYV (The Voice of Youth) to see if supporting mental health helps young people with HIV take their medication regularly. 690 youth aged 10-24 in Tanzania took part. The goal was to improve viral suppression by addressing mental health challenges…

This completed Phase 4 trial tested the HIV drug Biktarvy in 202 people who were newly diagnosed with HIV and had low CD4 counts (under 200), meaning they started treatment late. Participants received either Biktarvy or a standard three-drug combination. The main goal was to see …

This completed phase 4 trial tested whether adding SB Flavon (a blend of flavonoids, vitamin C, and L-arginine) to standard Tenofovir therapy can reverse advanced liver scarring (cirrhosis) and prevent liver cancer in 134 people with chronic hepatitis B. The study measured liver …

This study tested whether personalized text message reminders can help young people with HIV take their medication consistently. 210 participants from 12 clinics received either standard care or tailored text reminders for 6 months. The goal was to see if the texts improved medic…

This study tested whether a new form of interferon (IFN alfa-2b XL) combined with ribavirin works better and causes fewer side effects than the standard treatment for chronic hepatitis C (genotypes 1 or 4). 84 adults who had not been treated before or had not responded to previou…

This study tested two different approaches to help people recently released from jail or prison get connected to care for HIV, hepatitis C, STIs, and opioid use disorder. Over 600 adults took part. The goal was to see which method worked better for starting and staying on treatme…

This study tested whether switching from one immunosuppressant to everolimus, along with lowering overall immunosuppression, helps clear BK virus better than just lowering immunosuppression alone. The trial involved 130 kidney transplant recipients with BK virus in their blood. T…

This study tested whether starting HIV treatment on the same day and providing care in community centers for people who inject drugs improves viral suppression. 800 participants were randomly assigned to same-day or standard treatment start, and to community or government-based c…

This study tested the drug pravastatin in 21 HIV-positive people with high cholesterol who were already on HIV medications. The goal was to see if pravastatin could safely lower their cholesterol without affecting their HIV treatment. Participants received either pravastatin or a…

This study tested whether daily cassava root and sesame seed granules, along with nutrition education, could improve the nutritional health of adults with HIV. Sixty-four participants took part, receiving either the granules plus education or education alone for 16 weeks. The goa…

This study tested a drug called sEphB4-HSA in 23 people with Kaposi sarcoma, a type of skin cancer. The drug works by stopping blood vessels from feeding the cancer and may also slow cancer cell growth. The goal was to see how many patients responded to treatment and to check for…

This study tested three different ways to help people living with HIV stop smoking. Over 670 patients from 13 HIV clinics in Hanoi took part. Nurses either referred patients to a quitline, provided counseling, or offered counseling plus nicotine gum. The goal was to see which met…

This study tested a new once-daily combination pill (doravirine/islatravir) in 599 adults newly diagnosed with HIV-1 who had never taken HIV medication. The goal was to see if the new pill works as well as a standard three-drug regimen at keeping the virus under control. Results …

This study tested whether Mediterranean or DASH diets improve liver function in people with nonalcoholic fatty liver disease (NAFLD). 75 adults with mild to moderate liver enzyme elevations were split into three groups: one following general dietary guidelines, one on a Mediterra…

This study tested a two-part vaccine (Ad26.Mos4.HIV and MVA-BN-HIV) combined with three broadly neutralizing antibodies (PGT121, PGDM1400, VRC07-523LS) in 28 adults with HIV who were already on suppressive antiretroviral therapy (ART). The goal was to see if this combination coul…

This study looked at whether giving plasma (the liquid part of blood) from people who recovered from COVID-19 could help critically ill patients fight the virus. The plan was to collect plasma from up to 240 recovered donors and give it to sick patients. However, the plasma donat…

This study tested a stepped-care program where trained non-specialists provided mental health support and HIV medication adherence help to 280 people in rural Zimbabwe. Participants had both depression and high HIV viral loads. The goal was to see if this approach could improve v…

This study looked at two ways to control HIV in 171 adults who had never been treated before. Everyone started with a daily pill (dolutegravir/lamivudine). Once the virus was undetectable, participants could choose to switch to a shot (cabotegravir plus rilpivirine) given every t…

This Phase 2 trial tested an oral drug called selgantolimod in 29 adults with both chronic hepatitis B and HIV. Participants had been on stable antiviral therapy for both viruses for at least 5 years. The study aimed to see if the drug is safe and can lower hepatitis B surface an…

This study tested a simple tool that helps doctors choose the right stop-smoking medicines for people living with HIV. 371 smokers from three clinics took part. The goal was to see if the tool helped more people quit smoking for at least a week.

This study looked at whether it is safe to transplant livers from deceased HIV-positive donors into HIV-positive recipients. Researchers followed 80 participants to track complications like graft failure, infections, and HIV breakthrough. The goal was to see if using HIV-positive…

This study tested the safety and how the body processes the HIV drug dolutegravir in newborns whose mothers have HIV. A total of 48 mother-infant pairs from four countries participated. Infants received either a liquid or tablet form of the drug during their first weeks of life, …

This study tested whether a 12-week high-intensity exercise program could slow aging and reduce inflammation in 89 older veterans living with HIV. Participants exercised via video conferencing without needing special equipment. The goal was to improve fitness and quality of life,…

This early study tested a lab-made antibody called 3BNC117-LS in 43 people, some with HIV and some without. The goal was to see if it is safe and how long it stays in the body. If it works, this antibody might one day help control HIV with less frequent dosing.

This study tested a mobile phone-based wellness program (WISH) to help veterans with HIV quit smoking. 234 participants were split into two groups: one received the WISH program, the other got standard care (quitline and text support). The goal was to see if the wellness program …

This large, completed trial tested several potential COVID-19 treatments in over 1,500 hospitalized adults across Europe. Earlier drugs like remdesivir and hydroxychloroquine were dropped after showing no benefit. The current phase is testing a new antibody combination called AZD…

This early-phase study tested a new treatment called JX-594, a modified virus injected directly into liver tumors. The goal was to find the safest dose and see if it could shrink tumors in 14 patients with advanced liver cancer that had not responded to standard treatments. The s…

This Phase 3 trial tests a drug called bepirovirsen in nearly 1,000 adults with chronic hepatitis B who are already on standard antiviral therapy. The goal is to see if bepirovirsen can suppress the virus enough that participants can safely stop all hepatitis B medications and re…

This completed Phase 2 trial tested a new drug called lipovirtide, given as a weekly or biweekly injection, along with daily oral HIV medications. The study enrolled 64 HIV-positive adults who had never taken antiviral drugs before. Researchers measured how many participants had …

This study tested a combination of peginterferon alfa2a and ribavirin in 17 HIV-positive people with chronic hepatitis C who had not responded to earlier treatment. Participants received weekly injections and daily pills for 48 weeks. The main goal was to see if the virus became …

This study tested whether a vaginal insert containing artesunate, a malaria drug, could help clear HPV after standard cervical precancer treatment in women living with HIV. 120 women in Kenya used the insert or a placebo for 5 nights on and off over 6 weeks. The goal was to see i…

This study looked at whether adults aged 50 and older living with HIV could safely switch from a three-drug pill to a simpler two-drug pill (DTG/3TC) while keeping the virus under control. About 200 participants who already had undetectable virus levels made the switch and were f…

This Phase 3 study tests bepirovirsen, an experimental drug, in 857 adults with chronic hepatitis B who are already on standard antiviral therapy. The goal is to see if bepirovirsen can suppress the virus enough to allow patients to stop all hepatitis B treatments and remain viru…

This completed Phase 2/3 trial tested whether adding baloxavir to standard oseltamivir treatment helps hospitalized flu patients clear the virus faster. Fifteen adults with confirmed influenza were randomly assigned to receive either the combination or oseltamivir alone. The main…

This study tested a new drug called LP-98 in 40 people with HIV who had not taken any HIV medications before. Participants received different doses of LP-98 as a shot under the skin every two weeks for a total of four doses. The main goal was to check if the drug is safe and how …

This early-stage study tested a single injection of a new drug, lipovirtide, in 46 HIV-positive adults who had never taken antiviral medication. The main goal was to check if the drug is safe and how the body processes it. This is a first step toward finding new treatments to con…

This study looked at 38 kidney transplant patients who had CMV infection. Researchers wanted to see if measuring a type of immune cell (γδ T cells) could help decide who needs extra medication to prevent the virus from coming back. The goal is to avoid unnecessary drugs while sti…

This early-stage trial tested multiple doses of an injectable drug called lipovirtide in 24 adults with HIV who had never taken antiretroviral therapy. The main goal was to check safety and how the drug moves through the body, with a secondary look at whether it can lower HIV lev…

This study tested whether giving early treatment to adults with COVID-19 who have risk factors (like age over 60 or high blood pressure) could prevent them from needing oxygen, hospitalization, or dying. About 412 people took part. The goal was to see if these treatments are safe…

This study looked at whether a 16-week strength training program can prevent or reduce late effects like muscle loss, heart disease, and diabetes in adults who had a bone marrow transplant as children. 28 survivors and a matched control group participated. The goal was to see if …

This early-stage study tested a new experimental HIV medicine, GS-3242, in 27 people living with HIV-1. The goal was to see if the drug is safe and can lower the amount of virus in the blood over 11 days. Participants had not taken HIV medication for at least 12 weeks before the …

This study tested a new way to manage high blood pressure and heart disease risk in people living with HIV in Botswana. Over 4,600 adults on HIV treatment took part. The goal was to see if adding heart health checks and treatment to regular HIV clinic visits helps more people con…

This pilot study tested a text-message game called iTAG that uses points, a scoreboard, and motivational messages to encourage young people with HIV in Ghana to take their medication regularly. Twenty-one participants aged 18-24 received the game for 90 days. Researchers measured…

This phase 2a trial tested a new experimental drug called STP0404 (Pirmitegravir) in 25 adults with HIV-1 who had never taken HIV medications before. Participants received either a low, medium, or high dose of STP0404 or a placebo once daily for 10 days. The study measured how we…

This study tests an experimental drug called AHB-137 in healthy volunteers and people with chronic hepatitis B who are already on antiviral medication. The goal is to check if the drug is safe and shows early signs of controlling the virus. About 129 participants will receive eit…

This study tested a DNA-based vaccine called VGX-3100 in 44 HIV-positive adults with high-grade anal precancer caused by HPV types 16 or 18. The vaccine was given with a mild electric pulse (electroporation) to help cells absorb it and boost the immune system's attack on the abno…

This study tested an experimental mRNA vaccine (mRNA-1608) in 303 healthy adults aged 18 to 55 with recurrent genital herpes caused by HSV-2. The goal was to see if the vaccine is safe and can reduce the number of outbreaks. Participants received different doses of the vaccine or…

This study tested a new way to care for people who inject drugs and have hepatitis C. Along with standard hepatitis C treatment, participants were offered HIV prevention medication and buprenorphine for opioid use disorder. The goal was to see if this combined approach could cure…

This study tested a new mRNA booster shot (mRNA-1345) in 507 adults aged 60 and older who had already received a licensed RSV vaccine at least a year earlier. The goal was to see if the booster is safe and boosts the immune system's ability to fight RSV. Researchers measured side…

This study tested whether the BCG vaccine, normally used to prevent tuberculosis, could reduce the hidden HIV reservoir in people living with HIV who are on antiretroviral therapy. Sixty participants received either a single BCG shot or a placebo. Researchers measured changes in …

This study tested whether two lab-made antibodies, VRC01LS and 10-1074, could keep HIV under control in 30 children in Botswana who started treatment early. The children received the antibodies by infusion and stopped their regular HIV medication. Researchers monitored how many k…

This study looked at HIV-positive adults who switched from a standard three-drug therapy to either a two-drug or a three-drug regimen. Researchers wanted to see if the two-drug option could reduce long-term side effects while keeping the virus under control. The main focus was on…

This early-stage study tested a single dose of mesenchymal stromal cells in 7 COVID-19 patients with severe acute respiratory distress syndrome (ARDS) who were on ventilators. The main goal was to check safety, looking for serious side effects like heart problems or blood clots w…

This completed Phase 3 trial tested a once-daily combination of two drugs, lonafarnib and ritonavir, in 10 adults with chronic hepatitis D. The goal was to see if the regimen is safe and can lower the amount of virus in the blood over 48 weeks of treatment and 24 weeks of follow-…

This study tested whether nintedanib, a drug used for other lung diseases, can slow down lung damage in people who had severe COVID-19. It included 103 adults who still had lung problems more than 30 days after their COVID diagnosis. The main goal was to see if the drug helped ma…

This study tested two different medicines to prevent CMV infection in 70 kidney transplant patients at high risk. One group received the standard drug valganciclovir, while the other received maribavir plus acyclovir. The goal was to see which approach caused fewer side effects l…

This phase 2b trial tested a combination of two experimental vaccines (VTP-300) plus a low dose of the cancer drug nivolumab in 121 adults with chronic hepatitis B who were already on antiviral medication. The goal was to see if the treatment could significantly lower hepatitis B…

This small pilot study tested whether adding pegylated interferon lambda to standard care helps hospitalized adults with mild-to-moderate COVID-19 recover faster. Nine participants were randomly assigned to receive the drug or standard care alone. The study measured how long the …

This study tested whether livers from donors with hepatitis C could be safely transplanted into people without hepatitis C. Five patients on the liver transplant waiting list received these livers and were then treated with an antiviral drug to prevent infection. The goal was to …

This study tested a counseling program for couples in Zambia to help pregnant women living with HIV stay healthy. Nearly 500 couples took part. The program aimed to improve HIV medication adherence and viral suppression through relationship strengthening.

This study tested whether giving plasma from people who recovered from COVID-19 to those with severe or critical COVID-19 is safe and helps them get better. 350 adults received the plasma treatment. The main goals were to track serious side effects and see if fewer people died wi…

This study looked at how well the shingles vaccine works and how safe it is for people living with HIV. Researchers compared the immune response based on participants' CD4+ T-cell counts and age. The goal was to provide evidence to help guide vaccination recommendations for this …

This study looked at whether taking vitamin D3 for 3 months can lower inflammation and boost immune cells in people with HIV who are already on antiretroviral therapy. Twenty adults with early-stage HIV took vitamin D3 supplements. Researchers measured changes in inflammation mar…

This study tested a special digital pill and smartphone app to help HIV-negative men who have sex with men and who also have substance use disorder take their daily HIV prevention medication (PrEP) consistently. Forty participants took a PrEP pill with a sensor that recorded when…

This Phase 2 study tested an experimental drug called AB-729 combined with pegylated interferon and standard antiviral pills in 43 adults with chronic hepatitis B. The goal was to see if this approach could safely lower hepatitis B surface antigen levels and allow some participan…

This study tested whether three common drugs—metformin, ivermectin, and fluvoxamine—could prevent severe illness and long COVID in 1,323 adults with early COVID-19. Participants were overweight or obese and not hospitalized. The key finding was that metformin reduced the risk of …

This study tested a quick finger-prick blood test to see if cancer patients had been infected with COVID-19 in the past. Researchers enrolled 214 adults being treated for cancer. The goal was to find out how many had antibodies, including those without symptoms, to help clinics k…

This study looked at whether PET-CT scans can detect unique signs of COVID-19 in the lungs. Researchers scanned 22 patients suspected of having lung infections and compared the images to their COVID-19 test results. The goal was to find patterns that could help diagnose COVID-19 …

This study tested two new rapid tests that use a single nose swab to detect COVID-19, influenza A/B, and RSV. Researchers checked how accurate the tests are compared to standard lab methods and whether healthcare workers find them easy to use. The study involved 589 people with s…

This study collected nasal swabs, throat swabs, and saliva samples from 79 people with symptoms of flu, RSV, or COVID-19. The samples were used to help evaluate a point-of-care device called LumiraDx, which aims to quickly and accurately detect these viruses. The study focused on…

This study compares three automated blood tests (Abbott Architect, Siemens Immulite, and Diasorin Liaison) for diagnosing Epstein-Barr virus (EBV) infection. Researchers analyzed 91 blood samples from patients aged 3 to 82 to see how well each test detects key markers of EBV infe…

This study evaluates how well the LumiraDx SARS-CoV-2 Ag ULTRA test detects COVID-19 when used at point-of-care locations like clinics or pharmacies. Participants with COVID-19 symptoms provide nasal and nasopharyngeal swabs, and the test results are compared to a standard lab re…

This study checks whether a fingerstick blood test for COVID-19 antibodies gives the same results as standard lab tests using blood from a vein. About 42 people who recently had a positive COVID-19 PCR test will provide both fingerstick and venous blood samples. The goal is to se…

This study collected nose, throat, and blood samples from 523 adults with COVID-19 symptoms or a past positive test. The goal was to help develop and check the accuracy of a new rapid test for detecting COVID-19 antibodies and viral proteins. The test is designed to be used at th…

This study checked how well a new rapid test (LumiraDx) detects COVID-19 and flu A/B from a simple nose swab. Over 1,000 people with symptoms took part at clinics. The test aims to give fast results at the point of care, helping doctors tell these illnesses apart quickly.

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study checked how accurate two rapid tests (LumiraDx SARS-CoV-2 Ag Ultra and LumiraDx SARS-CoV-2 & Flu A/B) are at detecting COVID-19 and flu in people with symptoms. 716 participants provided nasal swabs at clinics. The results were compared to standard lab tests to measure…

This study tested a new rapid test (LumiraDx Influenza A/B + RSV Test) that uses a nasal swab to quickly detect flu A, flu B, and RSV. Over 500 people with cold or flu-like symptoms took part. The test was performed by healthcare workers at point-of-care sites and compared to sta…

This study tested a quick COVID-19 antigen test called LumiraDx at various point-of-care sites, like clinics. Over 1,100 people with COVID-19 symptoms took part. The test's accuracy was compared to standard lab methods to see how well it detects the virus.

This study tested a new saliva-based test for SARS-CoV-2 that gives results in less than an hour, without needing lab equipment. Researchers compared it to the standard PCR method using samples from 627 people, including healthcare workers and patients. The goal was to see if thi…

This study tested whether a shallow (2 cm) or deeper (4 cm) nasal swab is better at detecting COVID-19 using rapid antigen tests. Over 300 adults in Denmark each received both swab depths, and results were compared to a standard throat PCR test. The goal was to find the best bala…

This study tested whether people without special training can accurately use a portable device to detect hemorrhagic fever. Researchers compared results from trained and untrained users using blood samples from 725 people. The goal was to see if the test works well in real-world …

This study checked how well a new rapid test, TestNPass, can detect COVID-19 using a nose swab. It involved 400 adults at a hospital in France. The goal was to see if the test is accurate enough to replace slower PCR tests and provide a digital health pass.

This study checked how well new blood tests (Access HBV assays) can detect hepatitis B infection. Researchers tested over 21,000 leftover blood samples from adults, including blood donors and hospital patients. The goal was to see if these tests are accurate compared to existing …

This trial evaluates whether a hospital-based remedial vaccination strategy can improve Tdap-IPV (tetanus, diphtheria, pertussis, polio) vaccination rates in adults aged 65 and older in the Sarthe region of France. Participants are randomly assigned to receive either the remedial…

This study tests a counseling program called ACTPrEP, designed to help young Black men who have sex with men (ages 18-34) start and continue taking PrEP, a daily pill that prevents HIV. The program uses acceptance and commitment therapy to address thoughts and feelings that might…

This study tested a new medicine called SYN023 to prevent rabies in people who were bitten or scratched by animals like dogs or bats. About 448 adults with different levels of rabies risk received either SYN023 or the standard rabies immune globulin, along with the rabies vaccine…

This pilot study tested whether watching a culturally tailored telenovela (soap opera) online could help Latinas in North Carolina adopt HIV prevention behaviors like using condoms, getting tested, and learning about PrEP. 95 women participated, watching four 10-minute episodes o…

This large study tested whether an enhanced flu vaccine (Fluad) works better than standard flu shots in adults aged 65 and older. Over 38,000 participants received either Fluad or a regular vaccine. The goal was to see if Fluad prevents confirmed flu cases more effectively. Resul…

This study tested a mobile app called eSTEP designed to help men who have sex with men and transgender women at high risk for HIV start and continue taking PrEP, a daily pill or injection that prevents HIV. 113 participants were randomly assigned to use the app plus usual care or…

This study tested a mobile app called WeTest-WeLink to help high-risk men in China test themselves for HIV and connect to care. 1,800 HIV-negative men who have sex with men used the app or received standard information. The goal was to see if the app increased HIV self-testing an…

This study looked at whether a rabies vaccine (RabAvert) can be given just under the skin instead of into a muscle. Researchers tested it in 130 adults, some who had never been vaccinated and some who had. The goal was to see if the skin shot triggers enough protection and is saf…

This study tests two ways to prevent HIV: a rectal gel used before sex and daily pills. About 150 men will try each method for 8 weeks to see which is safer, easier to use, and more acceptable. The goal is to give people more choices for on-demand HIV prevention.

This study tested whether a booster dose of the Ebola vaccine (V920) could improve and extend immune protection in 248 healthy adults at risk of Ebola exposure through their jobs. Participants received the primary vaccine and were randomly assigned 18 months later to get a booste…

This completed trial in South Africa tested four support strategies—case management, food vouchers, peer buddies, and community PrEP pick-up points—to help female sex workers and young women stay on PrEP, a daily pill that prevents HIV. 304 participants were randomly assigned to …

This study tested a new medicine called CD388, given as a single set of three shots, to see if it can prevent the flu in healthy adults aged 18 to 64. Over 5,000 participants received either CD388 or a placebo. Researchers measured how many people got the flu over the next 24 wee…

This study looked at how safe and effective a daily HIV prevention pill (TAF-FTC) is in 54 Kenyan cisgender women. Participants took different numbers of doses each week to mimic real-world use. The goal was to measure drug levels in the blood and tissues, helping doctors better …

This study tested an experimental antibody called AZD3152 to see if it can safely prevent COVID-19 in people with weakened immune systems. About 3,882 adults received either the antibody or a placebo/comparator. The goal was to measure how well the antibody neutralizes the virus …

This study looks at how often cisgender women in Kenya need to take the HIV prevention pill Truvada (TDF-FTC) to keep protective drug levels in their blood. Participants are randomly assigned to take 2, 4, or 7 doses per week for up to 16 weeks, and their drug levels are measured…

This study tested a program designed to make HIV testing easier for men who have sex with men (MSM) in Lima, Peru. The program offered HIV testing at venues where people meet for sex, along with a text-messaging app that provides information and support. Researchers enrolled 161 …

This study tests whether a proven HIV prevention education program can be delivered through Facebook to reach high-risk rural women in Appalachia. Participants are women leaving jail who have a history of drug use and risky sexual behavior. The goal is to see if social media can …

This study tested whether a couples-focused counseling and testing program could help prevent HIV and improve care. 544 couples from rural South Africa took part. The goal was to see if this approach increases viral suppression and engagement in HIV care.

This study tested whether giving intravenous immunoglobulins (IVIG) could prevent BK virus infection in kidney transplant recipients. The virus often causes graft problems. Researchers enrolled 359 patients with low antibody levels against their donor's virus strain and gave some…

This pilot study tested different outreach methods—like automated calls, texts, and emails—to encourage parents in rural areas to get their children (ages 9-17) the HPV vaccine. The study involved 335 parents and caregivers at four community clinics in rural Washington. The main …

This completed Phase 3 trial tested a program called Safe South Africa, designed for teenage boys aged 15-17 in high-risk South African communities. The program includes two weekly group sessions and home activities to reduce HIV risk behaviors and intimate partner violence. Rese…

This study tested whether taking the tuberculosis prevention drug isoniazid for 36 months instead of the usual 6 months could better prevent TB in adults with HIV. Nearly 2,000 participants in Botswana were randomly assigned to either short or long treatment. The goal was to see …

This study tested four practical strategies—training providers, educating patients, improving electronic health records, and offering patient navigation—to increase use of HIV prevention pills (PrEP) among Black women. Over 700 women from 12 community clinics in the Midwest and S…

This pilot study tested whether offering sexual health services like HIV prevention pills (PrEP), STI testing, and birth control in hair salons could reach women who might not visit a clinic. About 436 women in Umlazi, South Africa, took part. Some salons offered these services, …

This study tested whether a peer-driven program could help African American and Hispanic/Latino men who have sex with men start taking PrEP, a daily pill that prevents HIV. 98 men who were not on PrEP joined the program. The goal was to see if talking with trained peers made them…

This study tested whether a mobile app (GeoPassport), financial incentives, and peer mentor support could help men who have sex with men and transgender women leaving jail access HIV prevention services like PrEP and testing. 233 participants were enrolled and followed for 9 mont…

This completed study tested a van-based program in Baltimore that offered drug checking and HIV prevention medication (PrEP) to people who use drugs. Nearly 500 participants were recruited to see if the program helped them start or stay on PrEP and reduce risky behaviors. The goa…

This study tested several types of flu vaccines in over 1,800 adults aged 65-82 in Hong Kong over four years. The goal was to see which vaccine or combination of vaccines provides the strongest and longest-lasting immune protection. Researchers measured antibody levels and immune…

This completed pilot study enrolled 101 transgender women and men who have sex with men to see how acceptable the HPV vaccine (Gardasil 9) is in these groups. Participants received three doses over six months, and researchers tracked how many completed the series and how common a…

This study tested a new way to prevent CMV infection in 42 CMV-positive kidney transplant patients. Researchers combined an antibody infusion with a specific type of immune cell (gamma delta T cells) to see if it could stop the virus from reactivating. The goal was to find a safe…

This study looked at two new ways to prevent RSV, a serious lung infection in babies: a vaccine given to pregnant women and an antibody shot given to infants. Researchers wanted to see how well each method works alone or together. 181 mother-infant pairs took part, and the study …

This study evaluated a program called PALMS that uses live movement and sound to teach HIV prevention to high-risk minority male teens aged 12-18 in juvenile justice or drug treatment centers. The goal was to see if the program reduces risky sexual behaviors and encourages HIV te…

This study tested a program called PARTI to help gay and bisexual men who use stimulants (like meth or cocaine) take their daily HIV prevention pill (PrEP) consistently. The program combined positive affect skills training with a smartphone-based reward system for taking PrEP. Re…

This study tested a new medicine called clesrovimab in over 1,000 infants and children at high risk for severe RSV disease. The goal was to see if it is safe and works as well as or better than the current standard treatment, palivizumab. Participants received either clesrovimab …

This large study tested an experimental HIV vaccine in over 5,400 healthy South African adults at risk of HIV. The vaccine was designed to teach the immune system to fight HIV. Unfortunately, the vaccine did not prevent HIV infection, and the trial was stopped early. The results …

This study tested a nose spray containing heparin, a common and safe medicine, to see if it could stop the spread of COVID-19 within households. Over 500 people who lived with someone who tested positive for COVID-19 used the spray or a dummy spray three times a day for 10 days. …

This study looked at different ways to help young women in South Africa, ages 18-25, take their daily HIV prevention pill (PrEP) consistently. The goal was to find the best support strategies to keep them protected from HIV. 360 women took part in the study, which tested a step-b…

This study tested whether giving families educational materials, alcohol-based hand sanitizers, and surgical face masks could reduce the spread of colds and flu among household members. Researchers followed 2,788 people in 450 households in Northern Manhattan for 15 months. They …

This study tested a program to help young men (ages 17-24) who have sex with men use HIV self-testing and PrEP (a daily pill to prevent HIV). 118 participants joined the pilot study. The program provided information, motivation, and skills to encourage HIV testing and PrEP use. T…

This large Phase 3 trial compared a new experimental mRNA COVID-19 vaccine (mRNA-1283) with Moderna's original vaccine (mRNA-1273) in over 13,500 people aged 12 and older. The goal was to see if the new vaccine is safer, triggers a better immune response, and prevents COVID-19 at…

This study tested a program to help Latino men who have sex with men get access to PrEP (HIV prevention pills), HIV testing, and mental health services. The program included one-on-one outreach sessions and a website with stories from other Latino men. The goal was to see if this…

This study tested whether offering a vaginal self-sampling kit directly to women aged 50-65 who had not had a cervical smear in over three years would increase screening participation. Women received a kit to use at home and mail to a lab for HPV testing. The goal was to see how …

This study looked at how well the seasonal flu vaccine works in adults who are hospitalized with severe flu-like illness. Researchers compared vaccinated and unvaccinated patients across a network of French hospitals to see if the vaccine reduced confirmed flu cases. The goal is …

This study tested a tablet-based app called COPPEhR designed to help older adults with HIV (age 50+) connect with others, access resources, and reduce loneliness. Sixty-eight participants either got the app or a tablet without it. The main goal was to see if the app was easy to u…

This pilot study tested a six-session culturally adapted cognitive behavioral therapy (Ca-CBT) for depression and anxiety in 50 people living with HIV in Pakistan. The therapy was delivered by trained HIV health workers and included culturally relevant stories and materials. The …

This pilot study tested a smartphone app called SiS-H, designed to help people with HIV quit smoking. 66 participants were randomly assigned to use either SiS-H or a standard quit guide app. The study measured how often people used the app and how acceptable it was, rather than d…

This study tested whether monthly 45-minute psychological interviews over 6 months could reduce post-traumatic stress symptoms in cancer patients affected by the COVID-19 pandemic. It included 29 adults with solid tumors who had moderate to high PTSD symptoms. The goal was to see…

This study tested a mobile app called EASE to help people manage anxiety and depression during the COVID-19 pandemic. It included 822 adults who identified as Black, Hispanic, or American Indian and had significant anxiety or depression symptoms. The app provided symptom tracking…

This study tested a new type of counseling called behavioral activation problem solving (BAPS) against standard smoking cessation counseling for people with HIV in Botswana. 651 participants were split into two groups to see which approach helped more people quit smoking. The goa…

This study looked at whether high-intensity interval training (short bursts of hard exercise) can improve physical function and reduce fatigue in adults aged 50-80 living with HIV who are sedentary and tired. Participants were randomly assigned to either high-intensity training o…

This study looked at whether taking a probiotic called LP28 can help older adults fight off colds and feel better. 102 people who had at least two colds in the past year took part. Researchers measured cold symptoms and immune cell levels to see if the probiotic made a difference…

This study tested whether transcranial magnetic stimulation (TMS) can reduce apathy—a severe lack of motivation—in older veterans with mild cognitive impairment (MCI). About 103 participants received either real or fake TMS over 20 sessions. The goal was to see if TMS could impro…

This study tested a 'Digital Strolling' program where people with severe mobility impairment use a virtual reality headset to walk in a digital world. 24 participants either used the VR walking or watched walking videos for 10 days. The goal was to see if this approach could impr…

This study tested new non-drug treatments to reduce nerve pain in the feet and legs of people with HIV. 161 adults with HIV-related nerve pain tried these approaches to see if they could ease pain and improve quality of life. The goal was to find better ways to manage this common…

This completed study looked at whether a once-a-week home-based resistance exercise program could help reduce fatigue in veterans aged 50 and older with Long COVID. The study enrolled 21 participants and measured changes in muscle strength and perceived tiredness. The goal was to…

This study tested whether a low-sugar diet, eating only during a 8-12 hour window each day, and periodic water fasts could reduce Long COVID symptoms. 77 adults with at least five Long COVID symptoms participated. The goal was to see if these dietary changes could lower symptom s…

This study looked at whether lying face down (prone positioning) helps hospitalized COVID-19 patients who have low oxygen levels but are not candidates for breathing machines. About 596 adults took part. The goal was to see if this simple position change could lower the chance of…

This study tested a training program for people living with HIV to help them become more active in managing their health. The program was delivered by psychologists and aimed to improve treatment adherence, quality of life, and emotional well-being. 75 participants took part in t…

This study tested whether a simple home program of breathing exercises and walking at least 6000 steps daily could ease long COVID symptoms like cough, breathlessness, and fatigue. Forty adults with long COVID followed the program for six weeks. Researchers tracked changes in sym…

This study tested whether showing children a visual guide about the dentist's office could lower their anxiety. 70 kids aged 5 to 14 were split into two groups: one got the picture-based lesson, the other got standard care. The children who saw the pictures reported less fear and…

This study tested a breathing exercise program for people with long COVID who still feel short of breath. 40 adults took part to see if the exercises could improve their breathing and daily activities compared to usual care. The goal was to find a simple way to help manage this c…

This study tested whether a gentle, noninvasive microcurrent treatment can reduce muscle pain in people who had COVID-19. Forty adults with post-COVID musculoskeletal pain were randomly assigned to receive either real or sham microcurrent therapy for 12 sessions. Researchers meas…

This study tested an online program called ORCHID that helps people with HIV feel more positive emotions. The goal was to see if it could reduce depression and improve HIV care. 29 adults from Chicago clinics took part. The program was designed to be used on a phone or computer.

This completed study tested a digital rehab program combining cognitive training, physical exercise, and mindfulness for people with long COVID who have memory and thinking problems. 172 adults with persistent cognitive symptoms at least 12 weeks after COVID-19 took part. The pro…

This study tested Pycnogenol, a natural pine bark extract, against a placebo in 153 adults with Long COVID. The goal was to see if it improves overall health and reduces symptoms like fatigue and brain fog. Participants took the supplement for 12 weeks and reported their health s…

This study compared a single dose of baloxavir marboxil to a 5-day course of oseltamivir in 100 Chinese children aged 1 to 12 with flu symptoms. The main goal was to check safety, including side effects. Researchers also measured how quickly symptoms like cough and fever improved…

This study looked at whether a 16-week program of aerobic and resistance exercise could improve physical function and reduce inflammation in HIV-infected veterans aged 50 and older. Thirty-three participants completed the program, and researchers measured changes in heart and mus…

This study looked at 324 people with hearing loss and an inner ear problem called enlarged vestibular aqueducts. Researchers collected DNA, hearing tests, and scans to find genes that may cause the condition. The goal was to learn more about why it happens, not to test a treatmen…

This study investigates how the immune system responds to COVID-19 in people with chronic lung conditions like asthma, COPD, or cystic fibrosis, compared to those without lung disease. Researchers collect blood, sputum, and nasal samples to measure immune signals and gene activit…

This completed early-phase study looked at how healthy adults respond to the rabies vaccine when given alone or with an immune-boosting shot (rabies immune globulin). Thirty participants received different combinations of vaccine and immune globulin to compare antibody levels ove…

This study looks at tiny nerve fibers in the skin of people with Long COVID, POTS, diabetic neuropathy, and those who had COVID-19 without lasting symptoms. By comparing skin samples, researchers hope to find unique patterns that help explain ongoing symptoms like pain and dizzin…

This study follows adults in Zambia who have both HIV and chronic hepatitis B to track liver health over up to 10 years. Researchers aim to understand how current HIV treatments affect hepatitis B and liver damage, and to identify factors that lead to serious outcomes like liver …

This study is testing whether an AI-powered chatbot on a smartphone can encourage more men in Malaysia to get tested for HIV. The study will enroll 296 men who have sex with men and have not been tested recently. Participants will use the chatbot and report every 30 days whether …

This study aimed to understand how the immune system responds to seasonal and H1N1 flu vaccines in healthy adults. Researchers collected blood and nasal samples from 203 NIH employees before and after vaccination. The goal was to analyze immune responses to improve future vaccine…

This study looks at cerebral small vessel disease (CSVD) — damage to tiny blood vessels in the brain that can cause memory loss and disability — in people with HIV over age 50. Researchers want to see if CSVD is linked to blood vessel problems in the eyes and kidneys, which could…

This completed Phase 1 study looked at 27 people with and without pulmonary hypertension to learn more about how blood vessel problems contribute to the disease. Researchers used heart catheterization, imaging, and blood tests to find biomarkers and understand disease mechanisms.…

This study follows thousands of pregnant women in France who had or likely had COVID-19 during pregnancy or shortly after giving birth. Researchers track health problems in both mothers and newborns up to 12 weeks after delivery, using medical records and questionnaires about men…

This study tests a program called SINCERE that screens people for social needs like food or housing help, then connects them to free community services with follow-up calls. Researchers want to see if this improves overall health, depression, and anxiety in 1500 adults at risk fo…

This study follows people aged 70 and older who were hospitalized with severe COVID-19 for one year after their diagnosis. Researchers aim to describe how many survive and how well they recover, including physical and mental function. The goal is to better understand the long-ter…

This study investigates how often cancer patients with COVID-19 develop dangerous blood clots (venous thromboembolism). Researchers will screen participants using ultrasound and blood tests to detect clots, whether or not they cause symptoms. The goal is to understand the true ra…

This study followed 1,377 people living with HIV in Liberia over three years to track how the disease progresses and affects their health. Researchers collected blood and urine samples, conducted physical exams, and asked about medications and risk behaviors. The goal was to gath…

This study followed 775 healthy children aged 2-9 in Cambodia over three years to learn how mosquitoes spread dengue and other viruses. Researchers took blood samples every wet and dry season to check for past or current infections. The goal was to understand why young children g…

This study followed 1,771 adults and children who received blood transfusions to check how safe the blood supply is. Researchers tested patients' blood for viruses like HIV and hepatitis before and after transfusion, and stored samples for future testing. The goal was to keep blo…

This study tested a document called Voicing My CHOiCES, designed to help young adults (ages 18-39) with serious illnesses like cancer or HIV discuss their care preferences. Participants filled out questionnaires about anxiety, social support, and communication, then reviewed the …

This study looks at anonymous health records from California and Louisiana to see if the Pfizer-BioNTech COVID-19 vaccine helps prevent post-COVID conditions (long COVID). Researchers will also track who gets vaccinated. The study includes adults with a COVID-19 diagnosis between…

This study looked at 200 people living with HIV in Liberia to compare two tests for latent tuberculosis (TB) infection: a blood test (IGRA) and a skin test (TST). The goal was to see which test works better in this population. Participants had a skin test and their results were c…

This study looked at the best way to test for COVID-19 in K-12 schools serving underserved communities. Researchers compared two strategies: testing only people with symptoms versus weekly testing of everyone plus symptom testing. The goal was to see which approach reduced COVID-…

This study looked at the emotional well-being of healthcare workers treating COVID-19 patients at two French hospitals. 78 staff members completed questionnaires about anxiety, depression, resilience, and empathy at different times during the pandemic. The goal was to understand …

This study tested over 1,500 hospital workers in four French hospitals for COVID-19 antibodies to see how many had been infected. Researchers compared infection rates among staff in COVID-19 units, other care areas, and non-care roles, and across regions with different outbreak i…

This study followed 92 people who had mild COVID and were treated at home. Two years after their diagnosis, they answered a questionnaire by mail about any hospital visits or other health events. The goal was to learn how outpatients fare over time and find patterns that could he…

This study reviewed medical records of 730 people who had bone marrow transplants between 2010 and 2015. Researchers wanted to learn how often viral infections happen after transplant and what factors make them more likely. No new treatments were tested; instead, the goal was to …

This study looks at how regular winter swimming—bathing in cold open water during winter—affects blood cells, blood flow, and stress-fighting enzymes in healthy men. Researchers compare winter swimmers to a control group who never swim in cold water and have a sedentary lifestyle…

This study tested whether community health workers with lived experience of incarceration could help people recently released from jail or prison get COVID-19 tests and adopt safety measures like mask-wearing and social distancing. The program included education, on-site testing,…

This study looked at how certain enzymes called matrix metalloproteinases (MMPs) and their inhibitors relate to human papillomavirus (HPV) in cervical dysplasia and cancer. Researchers collected tissue and cell samples from 216 women with different stages of cervical lesions. The…

This study tested whether using digital quiz games (Gimkit) or escape room activities helps nursing students learn more about HPV compared to traditional lectures. 90 nursing students took part, and their knowledge and literacy were measured before, after, and later. The goal is …

This completed study looked at how many people in southern Mali have ever been infected with Lassa virus and how many new infections occur each year. Over 8,500 participants aged 6 months to 99 years gave blood samples and answered questions about fevers and mouse exposure. The g…

This completed study looked at why some people develop scarring in their kidneys, including rare diseases like FSGS and a mysterious form of chronic kidney disease affecting farm workers. Researchers collected blood, urine, and kidney tissue from 537 participants to better unders…

This study tested a drug called suzetrigine, which blocks a specific nerve channel (NaV1.8) involved in pain signaling. In 67 healthy volunteers, tiny amounts were injected into the skin alongside a placebo and lidocaine. Participants received six different types of brief pain (e…

This study measured levels of mannose-binding lectin (MBL), a protein involved in immune response, in 97 ICU patients with severe H1N1-related acute respiratory distress syndrome (ARDS). Researchers wanted to see if higher or lower MBL levels were linked to a higher risk of death…

This study followed 380 people who had COVID-19 pneumonia for one year after they left the hospital. Researchers used heart ultrasounds, lab tests, and CT scans to check for heart problems. The goal was to understand how COVID-19 affects the heart over time.

This completed study looked at 25 young adults (ages 18-65) who had severe COVID-19 and now have thinking or memory problems. Researchers used a special PET-CT scan to see if there are changes in brain activity and how that relates to lung damage. The goal was to better understan…

This completed study looked at 378 kidney transplant patients to see if measuring antibodies against BK virus before transplant could predict whether the virus would reactivate after surgery. Researchers used a lab-made virus-like particle to test for five different BK virus type…

This study looked at 805 blood donors who tested positive for hepatitis C virus (HCV) to learn how the virus spreads and affects health over time. Researchers collected blood samples and health information to track infection and liver disease. The goal was to better understand HC…

This completed study looked at how COVID-19 affects the heart, lungs, brain, and kidneys in 202 people aged 18 to 80. Participants had imaging scans, blood tests, and other procedures to track inflammation and organ function over time. The goal was to understand why some people g…

This study used health records from over 8 million people in Taiwan to understand the effects of COVID-19 and how well the oral treatment nirmatrelvir/ritonavir works. Researchers looked at who got severely ill, needed hospital care, or died, and compared those who took the treat…

This study tracks how many infants in Germany receive nirsevimab, a long-acting antibody that helps protect against severe RSV disease. Researchers will survey parents of babies born during three RSV seasons (2024–2027) to measure immunization rates. The goal is to see how well t…

This study looked at how two types of exercise—high-intensity interval training (HIIT) and continuous moderate exercise—affect sleep and inflammation in 52 older adults with HIV. Participants exercised three times a week for 16 weeks. Researchers measured sleep quality through su…

This study tested whether people with chronic hepatitis B who had been on antiviral drugs for at least 4 years could safely stop treatment. Fifteen adults were monitored with monthly blood tests for 6 months after stopping, then every 3 months. The goal was to see if the virus st…

This study looked at liver fibrosis (scarring) in 127 HIV patients who had high liver enzymes while on antiretroviral therapy. Participants underwent tests like liver biopsy, ultrasound, and CT scans to measure liver damage. The goal was to understand how common and severe liver …

This study looked at whether it's possible to create a group of people with hepatitis C in Hai Phong, Vietnam, for future research. 300 adults with active hepatitis C took part. The goal was to see how many patients could be enrolled and how much information could be collected, n…

This study tracked 241 ICU patients with severe influenza to see how many developed a fungal lung infection called IAPA. Researchers collected blood and fluid samples to identify risk factors. The goal is to help doctors spot high-risk patients earlier.

This study checked how many organ transplant recipients in the U.S. have antibodies to the hepatitis E virus, which can become chronic in people with weakened immune systems. Researchers enrolled 447 adults who had a liver, kidney, or small bowel transplant or were on a waiting l…

This study collected tissue samples from the tonsils, lymph nodes, bowel, and lungs of HIV patients and healthy volunteers. The goal was to measure the amount of virus and certain immune cells in these tissues during treatment. By comparing samples, researchers hoped to learn mor…

This study looked at how patients recover right after two different types of chest surgery: open surgery (thoracotomy) and keyhole surgery (VATS). Researchers measured fear of movement, pain, breathing difficulty, fatigue, and anxiety in 18 adults before they left the hospital. T…

This study looks at how certain genetic changes (mutations) in the hepatitis B virus (HBV) affect the amount of virus in the blood of people with chronic infection. Researchers analyzed blood samples from 92 patients not on antiviral treatment. They found that specific mutations …

This study followed 324 people who had close contact with a confirmed COVID-19 case to see how long they shed the virus. Participants provided nasal swabs and reported symptoms over 12 days. The goal was to understand transmission risks and help shape public health policies.

This early-stage trial tested whether a combination of two HIV-1 activators is safe for people with HIV subtype B who are on standard antiretroviral therapy and have undetectable virus levels. Nine men participated, and the study focused on tracking side effects. The goal was to …

This study looked at 777 people with HIV in Brazil who failed their first treatment with tenofovir, lamivudine, and dolutegravir. Researchers wanted to understand what types of drug resistance and virus subtypes were involved. The goal is to improve treatment choices for people i…

This study looked at 37 critically ill COVID-19 patients who were moved by train from overcrowded ICUs in Paris to less busy ICUs in western France. Researchers tracked how many died, got infections, needed breathing machines, and how long they stayed in the hospital. The goal wa…

This study looked at whether ECMO, a machine that does the work of the heart and lungs, helps people with severe COVID-19 who have lung failure or heart failure. Researchers tracked 761 patients across France to see how many survived and how quickly they recovered. The goal was t…

This study looked at 21 adults with COVID-19 who had neurological symptoms like loss of smell, headache, or memory problems. Researchers used MRI scans to find brain changes linked to the virus. The goal was to better understand how COVID-19 can affect the brain, not to test a tr…

This study tested whether giving HIV self-test kits to HIV-negative pregnant women for their male partners would increase the number of men who get tested for HIV. Two hundred women in Malawi were split into two groups: one where partners got a clinic referral slip, and another w…

This study screens women who gave birth in four French hospitals for postpartum depression and anxiety during the COVID-19 pandemic. Participants fill out three questionnaires shortly after delivery and again about a month later. The goal is to measure how common postpartum depre…

This study looks at why certain immune cells (CD4 and CD8 T cells) remain activated in people with HIV whose viral load has been undetectable on antiretroviral therapy for at least two years. Researchers are investigating whether a common virus called cytomegalovirus (CMV) or an …

This study looked at how social support from friends and family can help teenagers with HIV stay in medical care and take their HIV medication regularly. Researchers worked with 60 teens in South Africa to understand which types of support work best. The goal is to design better …

This early-stage trial tested a single injection of JL18008, a lab-made protein designed to boost immune cells, in 40 healthy adults. The main goal was to check safety and how the body handles the drug. Researchers also measured changes in immune cell counts over 56 days. This is…

This study followed 163 people with chronic inflammatory rheumatism (like rheumatoid arthritis) who had a recent COVID-19 infection. Researchers measured their antibody levels over two years to see how immunosuppressive drugs affect antibody persistence. The goal was to better un…

This completed study used advanced MRI and CT scans to look for lasting damage in the brain, heart, lungs, and liver of 206 people who had COVID-19. Researchers compared those who were hospitalized with those who were not, to understand how the virus affects organs over time. The…

This study followed 326 adults in Zambia with chronic hepatitis B for up to 5 years. Researchers tracked how the virus behaves, how many patients need treatment, and how many develop serious liver problems like cirrhosis or liver cancer. The goal was to better understand the dise…

This study looked at how often thyroid problems (specifically an underactive thyroid) occur in people with HIV. Researchers reviewed medical records of 154 HIV-positive adults who were treated at a French hospital between 2001 and 2012. The goal was to get a clearer picture of th…

This study looked at how a person's genes might influence how sick they get from COVID-19. Researchers collected blood or saliva samples from 721 people in the U.S. who tested positive for the virus. The goal was to find genetic clues that could lead to better treatments in the f…

This study followed 250 chronic hepatitis B patients over age 30 who had detectable virus but normal liver enzyme levels (ALT). All had never received antiviral treatment before. Researchers measured how many became virus-negative after 48 weeks of antiviral therapy, and how many…

This completed pilot study scanned the brains of 30 people who were hospitalized with COVID-19 and later reported memory, concentration, or organizational problems—often called 'brain fog.' Researchers used MRI and spectroscopy to look for changes in brain structure and chemistry…

This study looked at whether a simple saliva test can find cytomegalovirus (CMV) in children aged 3 months to 6 years. Researchers collected saliva samples from 655 children in daycares and a hospital emergency department. The goal was to see how common the virus is and to check …

This completed study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or ankylosing spondylitis). Researchers used questionnaires to measure stress, depression, anxie…

This study looked at 190 HIV-positive women starting HIV medicines to see how often herpes virus symptoms appear or get worse. Researchers collected blood, urine, and vaginal samples over a year to track virus activity. The goal was to understand why some women have herpes flare-…

This study tested two methods to encourage COVID-19 testing among people who use opioids: having friends refer others (chain referral) and using trusted community members (credible messengers). About 500 people took part. The goal was to see which method got more people tested an…

This completed study tested different messages to see which ones make adults more willing to get the HPV vaccine, which prevents certain cancers. Over 5,300 adults aged 18-45 were randomly assigned to read one of five theory-based messages or a control message. The goal was to fi…

This study looked at how people living with HIV in rural Uganda experience stigma, including feelings of shame, loss of self-respect, and mistreatment by others. Researchers surveyed 180 adults to understand these experiences better. The goal was to gather information, not to pro…

This study looked at why some older adults (age 50 and up) maintain flu-fighting antibodies longer after getting the flu vaccine. Researchers enrolled 510 people and measured their immune response over time. The goal was to understand factors that help maintain protection, not to…

This study looked at children who survived Ebola and compared them to close contacts who never got sick. Researchers checked for brain, nerve, and thinking problems more than 5 years after infection. The goal was to understand what lasting issues survivors face, not to test a tre…

This study looked at two faster ways to test for hepatitis C in people who recently injected drugs and visit needle exchange programs. One method uses a fingerstick test with results in about an hour, and the other uses a dried blood spot sent to a lab. The goal was to see if the…

This study looked at 315 HIV-positive adults to build models that predict fatty liver disease and liver scarring. Researchers used ultrasound and FibroScan tests to track liver changes over time. The goal was to better understand and identify liver problems early in people living…

This study looked at 150 people with dengue fever to see if abdominal ultrasound findings, like gallbladder thickening or fluid in the belly, are linked to low platelet counts—a sign of severe disease. Researchers reviewed medical records and ultrasound images to find patterns th…

This completed study looked at nearly 29,000 adults who had non-cardiac surgery under general anesthesia in a large Canadian health region. Researchers wanted to see how often doctors used lung protective ventilation, a technique that uses smaller breaths and gentle pressure to r…

This study tested whether taking daily probiotic capsules for 4-5 weeks after a COVID-19 vaccine could improve the body's immune response. 138 healthy adults received either probiotics or a placebo. Researchers measured antibody levels and T-cell activity to see if probiotics mad…

This completed study looked at how often healthcare workers and first responders experienced short-term side effects (like fever or sore arm) after getting either the updated Novavax or Pfizer COVID-19 vaccine. About 660 adults who had at least one prior COVID-19 shot took part. …

This completed study followed 5 people with cystic fibrosis over two years to track COVID-19 antibodies from infection or vaccination. Researchers collected blood samples every six months to see how antibodies develop and last. The goal was to understand if people with CF have di…

This study looked at how not having enough healthy food (food insecurity) can lead to insulin resistance in people living with HIV. Researchers tested a community-based "food as medicine" program that provided healthy food and taught cooking and self-care skills. The goal was to …

This study looked at 236 kidney transplant patients to find out why some fail to develop immune protection against cytomegalovirus (CMV) in the first 45 days after surgery. Researchers reviewed medical records to compare patients who had a strong immune response with those who di…

This study looked at how the way we talk about the HPV vaccine affects university students' understanding and willingness to get vaccinated. Researchers gave 177 students either positive messages (focusing on benefits of vaccination) or negative messages (focusing on risks of not…

This study collected blood, saliva, and eye fluid samples from 343 people with uveitis, an inflammatory eye disease that can cause vision loss. Researchers aimed to learn which genes and other factors might lead to the disease and affect treatment response. Participants were foll…

This study tested a more concentrated version of the long-acting HIV drug cabotegravir in 138 healthy adults. Researchers gave the injection in different ways (into muscle or under the skin) to see how the body processes it and to check for side effects. The goal was to gather sa…

This study tracked 204 patients with blood cancers or those on certain immune-suppressing treatments to see how often COVID-19 infection persists for 21 days or more. Researchers also looked for factors that make a long infection more likely. The goal was to better understand who…

This study tested a streamlined HIV care approach for pregnant and postpartum women and their infants at a hospital in Kenya. The goal was to see if offering simpler, more flexible services could reduce clinic wait times and keep mothers and babies healthy. Researchers tracked vi…

This early-stage study looked at how the experimental drug ALG-097558 behaves in 16 people with moderate liver impairment compared to healthy volunteers. The goal was to measure drug levels and safety, not to treat COVID-19. Results will help guide future dosing for patients with…

This study followed 122 COVID-19 patients who were in the ICU, along with their family members, for up to a year after leaving the hospital. Researchers measured physical health, mental well-being, and how well people returned to work and daily life. The goal was to learn about t…

This early study tests how the experimental COVID-19 drug ALG-097558 moves through the body in people with severe kidney problems compared to healthy volunteers. Twelve adults will take multiple doses of the drug. The goal is to see if kidney function affects drug levels and safe…

This study looked at whether neck muscle activity during sleep affects breathing recovery in 17 COVID-19 patients who were on ventilators in the ICU. Researchers used sleep tests and activity monitors to track sleep quality and breathing patterns. The goal was to understand why s…

This study looked at 537 patients with respiratory infection symptoms to see how the types of viruses and bacteria changed from the COVID-19 pandemic period to after it. Researchers used a special PCR test to detect multiple germs at once. The goal was to understand how pandemic …

This study looked at over 13,000 people with chronic inflammatory rheumatism or autoimmune diseases who had or were suspected to have COVID-19. Researchers tracked how many developed severe COVID-19 requiring intensive care or leading to death. They also examined risk factors lik…

This study looked at how many people with cirrhosis in French general hospitals were vaccinated against diseases like hepatitis, flu, and COVID-19. Researchers surveyed 742 patients to see if they were up to date on their shots. The goal was to find gaps in vaccination coverage s…

This study looked at how the COVID-19 lockdown changed blood sugar control and self-care in 77 young people aged 13 to 25 with type 1 diabetes. Researchers used data from a glucose monitoring platform to compare blood sugar levels before, during, and after the two-month lockdown …

This study looked at 46 infants under 2 years old in the pediatric ICU with severe bronchiolitis. Researchers used a heart ultrasound measure called TAPSE to see if it could predict how long babies needed intensive care. The goal was to find a simple test that helps doctors plan …

This study looked at markers of inflammation, blood clotting, and blood vessel function in 310 HIV-infected adults and healthy volunteers. Researchers collected blood samples to understand how these markers relate to HIV and risks like heart disease or stroke. The goal was to gat…

This study involved over 2,500 people of all ages to find out which immune responses best predict protection against COVID-19 after vaccination. Researchers also tested whether local pharmacies could collect blood and nasal samples effectively. The goal is to improve future vacci…

This study looked at how the immune system of healthy adults aged 65-75 responds to RSV, a common cause of chest infections. Researchers gave volunteers a mild RSV infection and took blood and nose samples to find immune markers linked to protection. The goal is to use these find…

This study followed 610 adults who had heart surgery to see how often they develop postoperative delirium—a sudden state of confusion that can come and go. Researchers collected information on known risk factors like age, high blood pressure, and diabetes, and tracked outcomes su…

This study looked at whether having COVID-19 makes people more likely to develop a pulmonary embolism (a blood clot in the lungs). Researchers reviewed medical records of 347 patients who had a CT scan of their lungs. They compared those who tested positive for COVID-19 with thos…

This study from the University of Sao Paulo looked at whether measuring blood pressure during an exercise test can help predict outcomes in adults with flu-like symptoms, especially those who are unvaccinated. Researchers enrolled 62 participants and followed them for 30 days. Th…

This study collected information from 550 adults treated for COVID-19 at Methodist Health System facilities. Researchers looked at patient details, treatments given, and how well patients recovered. The goal was to better understand COVID-19 and improve future care, not to test a…

This study examined how veterans with HIV use My HealtheVet (MHV), an online health portal, to manage their condition. Researchers reviewed medical records and interviewed 123 veterans to understand the impact of MHV on HIV care. The goal was to develop and test an intervention t…

This study tested a short health game designed for parents and their 11-14 year old children to encourage HPV vaccination. Researchers enrolled 133 families with unvaccinated kids to see if the game was easy to use and acceptable. The goal was to learn if this low-cost approach c…

This study monitored 201 people with multiple myeloma to see how well COVID-19 vaccines and boosters work for them. Since their immune systems are weaker, researchers wanted to learn if vaccines still provide good protection. The goal was to find better ways to keep this vulnerab…

This study tested how a potential COVID-19 drug, ALG-097558, interacts with other medicines and food in 51 healthy adults. It also compared two tablet forms of the drug. The goal was to gather safety and dosing information, not to treat the disease. Results will help guide future…

This completed study in Hong Kong enrolled 977 adults aged 18-45 to understand how getting the flu vaccine year after year changes the body's immune response. Participants received either the Flublok vaccine or a saline placebo. Researchers measured antibody levels and looked for…

This study looked at how the COVID-19 pandemic and related public health measures changed asthma control in children aged 3 to 16. Researchers compared asthma control and flare-ups in 577 children during the pandemic to data from before the pandemic. The goal was to see if lockdo…

This completed study followed 829 people, including healthcare workers and a comparison group, over several years to understand how SARS-CoV-2 spreads and who gets sicker. Researchers collected swabs, blood, and saliva samples along with survey data. The goal was to identify risk…

This study offered a rapid hepatitis C test to 1,500 women aged 50-74 who were already coming in for breast cancer screening in Montpellier, France. The goal was to see how many women would agree to the extra test and how many had undiagnosed hepatitis C. Women who tested positiv…

This study looked at how different messages affect Japanese parents' willingness to get the HPV vaccine for their daughters aged 12-18. Over 1300 parents took part in surveys and experiments. The goal was to find better ways to communicate about the vaccine and increase acceptanc…

This first-in-human study tested a single dose of LP-98 injection in 36 healthy adults to see if it is safe and how the body processes it. Participants received either LP-98 or a placebo by injection under the skin or into a vein. The study is complete, but it only looked at safe…

This study tested a new ultrasound technique called ARFI to measure liver stiffness in 109 people, including healthy volunteers and patients with liver conditions. The goal was to understand normal stiffness values and how they change with disease or treatment. This is an observa…

This study looked at 60 adults having lung surgery (VATS) to see how three different anesthesia methods affect stress markers in the blood. The goal was to measure changes in oxidative stress, not to treat a disease. Results may help doctors choose the best anesthesia for future …

This study tested whether one-on-one support from a resource navigator helps long-term care and retirement home staff access health and wellness resources. 123 staff members took part, with some getting a navigator and others not. Researchers measured changes in wellness, burnout…

This completed study looked at how measles infection affects children's existing immunity and their ability to respond to vaccines. Researchers enrolled 264 children aged 1-15 in African regions, comparing those with acute measles to healthy controls. Participants received rabies…

This study looked at how many people in Punta Arenas, Chile, have persistent COVID-19 (long COVID) — symptoms lasting more than 4 weeks after infection. Researchers surveyed and tested 282 adults who had COVID-19, checking their physical and mental health, and looking for risk fa…

This study looked at whether lying face down (prone position) while awake can improve how air moves through the lungs in COVID-19 patients with breathing failure. Twenty adults with COVID-19 and low oxygen levels were monitored using a special imaging technique (EIT) to measure l…

This completed study looked at 172 people with and without HIV to understand why those with HIV have a higher risk of diabetes. Researchers examined fat tissue and immune cells to see if chronic immune activation in fat contributes to insulin resistance. The goal was to learn how…

This study checks on 137 COVID-19 patients who were in the ICU and used awake prone positioning (lying on their belly) while on high-flow oxygen. Researchers want to see if this technique affects quality of life and survival more than two years later. Participants answer a phone …

This study followed 241 adults hospitalized with the flu to see how the infection impacts the heart. Researchers tracked heart complications like new or worsening heart failure, heart attacks, and cardiac arrest. The goal was to better understand the link between influenza and he…

This completed study looked at 4000 COVID-19 patients in Swedish ICUs who needed a breathing machine. Researchers compared outcomes based on how soon after starting ventilation a tracheostomy was performed. The goal was to see if earlier or later timing affects how many days pati…

This study followed 384 people with HIV who were already taking the medication TAF. Researchers used a special blood test to measure how well participants were taking their pills and whether that predicted if the virus stayed under control. The goal was to see if this test could …

This study tested a 4-session program that helps HIV+ Asian Pacific American men manage their health with support from family. Nineteen men took part to see if the program was acceptable and practical. The goal was to learn if this approach could help this community better manage…

This completed study looked at 227 people with HIV who are on antiretroviral therapy. Researchers examined their oral health—including cavities, gum disease, and dry mouth—and checked for links to metabolic problems and ongoing inflammation. The goal was to understand if poor ora…

This early-stage study tested the safety of a new drug called EV68-228-N in 36 healthy adults aged 18 to 49. Participants received a single dose of the drug or a placebo by IV, and were monitored for side effects for up to 29 days. The goal was not to treat any disease, but to ga…

This study looked at 176 people who had COVID-19 and were having problems with smell, taste, or saliva. Researchers tested their senses and tried smell training as a way to help. The goal was to better understand these long-lasting symptoms and how to manage them.

This study looked at how the COVID-19 pandemic affected the mental health of 193 Amish and Mennonite adults who already had depression, anxiety, or bipolar disorder. Participants filled out surveys about their symptoms and pandemic-related stress over two years. The goal was to u…

This study looked at how the COVID-19 pandemic affected children with eating disorders and their families in Canada. Researchers tested virtual support groups led by parents who have been through similar experiences. They interviewed parents, youth, and healthcare workers to see …

This completed study looked at 550 people with mpox to see how long the virus stays in the body and how it spreads to close contacts. Researchers measured viral levels in skin lesions, throat swabs, and blood over time. The goal is to provide better guidance on when it's safe to …

This completed Phase 1 study looked at how much of the COVID-19 treatment nirmatrelvir/ritonavir (Paxlovid) gets into breast milk. Eight healthy breastfeeding women took the drug by mouth three times over two days. Researchers collected breast milk samples to measure drug levels,…

This study aimed to increase COVID-19 vaccination among African American and Latinx communities in four Michigan counties. Researchers worked with community partners to understand why some people were hesitant to get the vaccine and tested ways to encourage uptake. Over 1,100 adu…

This study surveyed over 3,400 university students and staff to learn what factors influence their decision to get a COVID-19 vaccine. Participants answered questions about vaccine effectiveness, side effects, costs, and incentives. The goal was to better understand preferences a…

This completed study looked at lung function in 42 people recovering from COVID-19. Participants inhaled a special form of xenon gas that shows up on MRI scans, allowing researchers to see how well different parts of the lungs were working. The goal was to understand how mild, mo…

This completed study gave 11 healthy adults a specially made H3N2 flu virus via nasal spray to see how their immune systems reacted. Participants were quarantined for at least 8 days in a hospital-like setting. The goal was to learn more about flu infection and immune response, n…

This study followed 201 adults with diabetes who were hospitalized for COVID-19 in Algeria. Researchers tracked their blood sugar, weight, and kidney function for up to a year after leaving the hospital. The goal was to learn how COVID-19 affects long-term diabetes control and to…

This completed study tested a small-group discussion program called SISTA-P for Black women at high risk for HIV. The program covered self-care, HIV and PrEP education, and assertiveness skills. Researchers enrolled 23 women in Washington D.C., Atlanta, and New Orleans to see if …

This study looked at how well CPAP therapy works for COVID-19 patients who have trouble breathing. Researchers collected data from 250 patients in a hospital to see how they responded to treatment. The goal was to learn more about managing severe COVID-19 in real-life settings.

This completed study enrolled 818 adults hospitalized with COVID-19 to examine how genetic, inflammatory, and other blood markers relate to disease severity and death. Researchers tracked outcomes like recovery or death and analyzed risk factors using statistical models. The goal…

This study looked at how bacteria from the gut might travel to the liver and make liver disease worse in people with hepatitis C. Thirty adults with stable liver disease took part. Researchers used blood tests, MRI scans, and liver tissue samples to measure bacterial movement and…

This study tested a new urine-based rapid test (UTRA) that checks if people with HIV are taking their medication tenofovir as prescribed. The goal is to catch adherence problems early, before the virus level in blood rises. Researchers compared the urine test results with blood d…

This study tested simple toolkits to encourage women living with HIV in Ghana to collect their own samples for HPV testing, which can help prevent cervical cancer. About 108 women took part, and the researchers checked if they completed and returned the self-sampling kit or got a…

This study looked at children and young adults under 24 who had COVID-19, including those with cancer. Researchers collected samples and medical information to learn about symptoms, risk factors, and how the virus spreads. The goal was to better understand the disease in younger …

This study tested 892 African and Asian immigrants for hepatitis B and C to understand how these infections raise the risk of liver cancer. Researchers also checked vaccination rates and tracked new cancer cases over time. No treatment was given; the goal was to gather informatio…

This completed study followed 917 adults with COVID-19 who were prescribed Paxlovid. Researchers wanted to see how often people test positive again after finishing the 5-day treatment. The goal is to better understand the so-called 'Paxlovid rebound' and help guide future care.

This study examined whether being in the ICU with COVID-19 made patients more likely to pick up dangerous, drug-resistant bacteria. Researchers tracked 368 critically ill adults to compare infection rates before and during the pandemic. The goal was to understand if COVID-19 chan…

This completed study from France compared over 1,500 ICU patients on ventilators to see if those with COVID-19 develop more lung infections than patients with influenza or no viral pneumonia. Researchers tracked cases of ventilator-associated pneumonia and tracheobronchitis. The …

This completed study tested whether phenelzine, a drug used for depression, could change how immune cells behave in people with COVID-19. Researchers took blood samples from 51 patients and exposed the cells to phenelzine in the lab. The goal was to see if the drug could reduce o…

This study followed 516 HIV-positive men who have sex with men over two years to track anal HPV infection and related lesions. Researchers used exams and anoscopy to see how often high-grade lesions appear or go away on their own. The goal is to gather evidence to better prevent …

This study investigates why the gut immune barrier remains damaged in people with HIV even after successful antiretroviral therapy. Researchers collected blood and intestinal biopsies from 80 participants to measure immune cells and inflammation. The goal is to understand why the…