HIV shot could replace daily pills for those who skip doses
NCT ID NCT03635788
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether monthly injections of two HIV drugs (cabotegravir and rilpivirine) work better than daily oral pills for people with HIV who have a history of missing doses. Over 450 participants were enrolled. The goal was to see if the long-acting shots reduce the chance of treatment failure or viral rebound compared to standard daily pills.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Cabotegravir and Rilpivirine long-acting injectable
What this could lead to
If successful, this could offer a convenient monthly injection option for people with HIV who have trouble taking daily pills, improving viral control and reducing transmission risk.
What could go wrong
This is a phase 3 trial, but results are not yet published. The injectable regimen may still fail in some participants, and injection site reactions or other side effects could occur.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Alabama CRS
Birmingham, Alabama, 35294, United States
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Brigham and Women's Hospital Therapeutics Clinical Research Site (BWH TCRS) CRS
Boston, Massachusetts, 02115, United States
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Case Clinical Research Site
Cleveland, Ohio, 44106, United States
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Chapel Hill CRS
Chapel Hill, North Carolina, 27599, United States
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Cincinnati Clinical Research Site
Cincinnati, Ohio, 45219, United States
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Columbia P&S CRS
New York, New York, 10032-3732, United States
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Greensboro CRS
Greensboro, North Carolina, 27401, United States
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Harbor-UCLA CRS
Torrance, California, 90502, United States
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Houston AIDS Research Team CRS
Houston, Texas, 77030, United States
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Jacobi Med. Ctr. Bronx NICHD CRS
The Bronx, New York, 10461, United States
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Johns Hopkins University CRS
Baltimore, Maryland, 21205, United States
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Massachusetts General Hospital CRS (MGH CRS)
Boston, Massachusetts, 02114, United States
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New Jersey Medical School Clinical Research Center CRS
Newark, New Jersey, 07103, United States
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Northwestern University CRS
Chicago, Illinois, 60611, United States
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Ohio State University CRS
Columbus, Ohio, 43210, United States
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Penn Therapeutics, CRS
Philadelphia, Pennsylvania, 19104, United States
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Puerto Rico AIDS Clinical Trials Unit CRS
San Juan, 00935, Puerto Rico
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Rush University CRS
Chicago, Illinois, 60612, United States
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SUNY Stony Brook NICHD CRS
Stony Brook, New York, 11794, United States
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The Miriam Hospital Clinical Research Site (TMH CRS) CRS
Providence, Rhode Island, 02906, United States
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The Ponce de Leon Center CRS
Atlanta, Georgia, 30308-2012, United States
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UCLA CARE Center CRS
Los Angeles, California, 90035, United States
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UCSD Antiviral Research Center CRS
San Diego, California, 92103, United States
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Ucsf Hiv/Aids Crs
San Francisco, California, 94110, United States
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Univ. of Florida Jacksonville NICHD CRS
Jacksonville, Florida, 32209, United States
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University of Colorado Hospital CRS
Aurora, Colorado, 80045, United States
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University of Pittsburgh CRS
Pittsburgh, Pennsylvania, 15213, United States
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University of Southern California CRS
Los Angeles, California, 90033-1079, United States
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University of Washington AIDS CRS
Seattle, Washington, 98104-9929, United States
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Vanderbilt Therapeutics (VT) CRS
Nashville, Tennessee, 37204, United States
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Washington University Therapeutics (WT) CRS
St Louis, Missouri, 63110-1010, United States
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Weill Cornell Chelsea CRS
New York, New York, 10010, United States
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Weill Cornell Uptown CRS
New York, New York, 10065, United States