Can a cancer drug combo fight frailty in HIV?
NCT ID NCT07144293
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2 trial tests whether a combination of dasatinib and quercetin (D+Q) can safely improve physical function in 82 older adults with HIV who are frail or prefrail. Participants take D+Q or a placebo in six 2-day cycles over 12 weeks, then are monitored for another 12 weeks. The study measures side effects, walking speed, and balance.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
dasatinib and quercetin (D+Q)
What this could lead to
If it works, this could point toward a treatment to reduce frailty and improve physical ability in older people with HIV.
What could go wrong
This is a small, early-phase trial with only 82 participants. The treatment may not work or could cause side effects. Results may not apply to everyone.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Brigham and Women's Hospital Therapeutics Clinical Research Site (BWH TCRS) CRS (Site ID: 107)
Boston, Massachusetts, 02115, United States
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Case CRS (Site ID: 2501)
Cleveland, Ohio, 44106, United States
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Chapel Hill CRS (Site ID: 3201)
Chapel Hill, North Carolina, 27599, United States
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Cincinnati CRS (Site ID: 2401)
Cincinnati, Ohio, 45267-0405, United States
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Columbia Physicians & Surgeons (P&S) CRS (Site ID: 30329)
New York, New York, 10032, United States
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Greensboro CRS (Site ID: 3203)
Greensboro, North Carolina, 27401, United States
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Harbor University of California Los Angeles Center CRS (Site ID: 603)
Torrance, California, 90502, United States
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Houston Advancing Research Team CRS (Site ID: 31473)
Houston, Texas, 77030, United States
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Massachusetts General Hospital CRS (MGH CRS) (Site ID: 101)
Boston, Massachusetts, 02114, United States
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New Jersey Medical School Clinical Research Center CRS (Site ID: 31786)
Newark, New Jersey, 07103, United States
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Northwestern University CRS (Site ID: 2701)
Chicago, Illinois, 60611, United States
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Ohio State University CRS (Site ID: 2301)
Columbus, Ohio, 43210, United States
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Penn Therapeutics CRS (Site ID: 6201)
Philadelphia, Pennsylvania, 19104, United States
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UCSD Antiviral Research Center CRS (Site ID: 701)
San Diego, California, 92103, United States
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University of California, Los Angeles CARE Center CRS (Site ID: 601)
Los Angeles, California, 90035-4709, United States
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University of California, San Francisco HIV/AIDS CRS (Site ID: 801)
San Francisco, California, 94143, United States
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University of Colorado Hospital CRS (Site ID: 6101)
Aurora, Colorado, 80045, United States
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University of Pittsburgh CRS (Site ID: 1001)
Pittsburgh, Pennsylvania, 15213, United States
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University of Rochester Adult HIV Therapeutic Strategies Network CRS (Site ID: 31787)
Rochester, New York, 14642, United States
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University of Washington Positive Research CRS (Site ID: 1401)
Seattle, Washington, 98104-9929, United States
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Vanderbilt Therapeutics (VT) CRS (Site ID: 3652)
Nashville, Tennessee, 37204, United States
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Washington University Therapeutics (WT) CRS (Site ID: 2101)
St Louis, Missouri, 63110-1010, United States
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Weill Cornell Chelsea CRS (Site ID: 7804)
New York, New York, 10010, United States
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Weill Cornell Uptown CRS (Site ID: 7803)
New York, New York, 10065, United States
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Whitman-Walker Institute, Inc. CRS (Site ID: 31791)
Washington D.C., District of Columbia, 20009, United States