FRAILTY

This study is testing whether a 12-week high-intensity interval training (HIIT) program can help reduce frailty and improve resilience in older veterans. Researchers will enroll 200 veterans aged 65 and older to compare exercise done at a center versus at home. The goal is to see…

This study is testing whether a special high-protein egg white pudding can help people with kidney failure who are on dialysis. Researchers want to see if this pudding is a practical supplement that can improve nutrition and measures of strength and frailty. Participants will rec…

This study is testing if a minimally invasive procedure to fix a severely leaky heart valve (tricuspid valve) helps older adults feel better and function better. Researchers will check if the procedure improves kidney function, reduces leg swelling, increases walking ability, and…

This study is testing whether a daily supplement made from fruit and vegetable compounds (polyphenols) can make exercise more effective for improving strength and physical function in adults over 60. For 12 weeks, 40 participants will follow a supervised exercise program while ta…

This study is testing whether a pre-surgery support program helps women with ovarian or endometrial cancer recover better. The program includes exercise, nutritional advice, and psychological support before their operation. Researchers will compare patients who receive this extra…

This study is testing whether taking oral capsules containing healthy donor stool (fecal microbiota transplantation) can help control aging-related decline in older adults. Researchers will enroll 210 people aged 70-85 to receive either the treatment or a placebo, then track chan…

This study is testing a home-based exercise and education program designed to help physically frail older adults get stronger before they undergo lung surgery. The goal is to see if this 'prehab' program is practical to run and if it helps patients recover better with fewer compl…

This study is testing a personalized care plan designed to help older adults manage frailty and maintain their independence. Researchers will work with 600 participants aged 60 and older to create and follow these customized plans for one year. The goal is to see how well this ap…

This small pilot study is testing whether a virtual home-based exercise and education program is practical for frail patients waiting for a kidney transplant. The goal is to see if patients can and will follow the program, and to gather information to plan a larger future study. …

This study is testing whether a supplement called MitoQ can help frail older adults who have trouble walking or thinking. Researchers want to see if MitoQ improves blood vessel function, which could lead to better walking speed and memory. The trial will enroll 60 participants ag…

This study is testing whether a monthly monitoring program can help older adults with multiple myeloma maintain their independence. The program checks six key areas of health like mobility and memory to catch problems early. Researchers want to see if patients can stick with the …

This study is comparing two different physiotherapy counseling methods to help older adults with early frailty become more physically active. It will involve 20 physiotherapists and their patients across Canada. The goal is to see if a new approach focused on balancing activity, …

This study is testing whether giving doctors a quick 10-minute geriatric assessment helps them create better, more personalized diabetes treatment plans for patients aged 60 and older. Researchers will see if this tailored approach leads to fewer dangerous events like falls, infe…

This study is testing a personalized treatment approach for adults aged 65+ with newly diagnosed multiple myeloma, a blood cancer. The goal is to adjust medication strength based on each person's changing health and frailty level over time, aiming to better balance effectiveness …

This study is testing a short questionnaire that family doctors can use to spot early signs of frailty in independent seniors over 65. Researchers want to see if this quick office test works as well as a much longer, specialized geriatric evaluation. The goal is to help doctors i…

This 6-year study tests whether structured health conversations help adults aged 67-84 maintain their quality of life and independence. Researchers will compare nearly 3,000 participants who receive these talks with similar groups who don't, tracking healthcare use, daily functio…

This study is testing a 20-week home exercise program designed for older adults who are at risk of losing strength and mobility after a hospital stay. Researchers want to see if a personalized, strength-based exercise routine done at home can help improve physical function and qu…

This study is testing whether a special home support program helps frail, older adults recover better after colon cancer surgery. The program includes a health check, diet advice, and exercise guidance provided at home after leaving the hospital. Researchers will compare recovery…

This study is testing whether a compound found in green tea, called EGCG, can help older adults who have survived cancer feel less frail and reduce body inflammation. About 118 participants aged 65+ who have finished cancer treatment will take either EGCG or a placebo pill daily …

This small pilot study is testing whether a simple ear acupressure technique can boost the benefits of standard pre-surgery exercise programs (prehabilitation) for people facing major lung surgery. Researchers will give 40 participants small seeds to press on specific points of t…

This study is testing whether a more structured care plan can better manage symptoms and improve the care experience for adults with advanced cancer who are receiving outpatient palliative care. Researchers will compare a new structured approach, which uses specific patient-repor…

This study is testing whether a special 12-week exercise program can help older adults living in nursing homes. The program aims to improve their strength, balance, walking, and thinking skills, while also trying to reduce their risk of falling. Researchers will compare this exer…

This study is testing whether special 'dynamic' lighting in hospital rooms can help improve sleep and daily rhythms for elderly patients. It will involve 300 patients over age 65 who are hospitalized. Researchers will compare patients in rooms with the special lighting to those i…

This study is testing whether a mobile app called 'SUPERAGING' is practical and safe for helping older adults who are frail or becoming frail. The app provides a 16-week program of personalized physical exercises, brain training games, and nutritional advice. Researchers will mai…

This study is testing whether two different forms of NMN supplements can help healthy adults aged 60-80 exercise longer and feel less tired. Participants will take either a special NMN blend called EGA® or regular NMN for a period, then switch. Researchers will measure how long p…

This study aims to understand how and why critically ill patients lose muscle mass, a condition linked to frailty and poor recovery. Researchers will observe 250 adults in intensive care to identify factors that might be changed to help patients get stronger. The goal is to gathe…

This study aims to see if measuring a patient's overall physical weakness (frailty) can improve doctors' ability to predict who is most at risk of dying after hip fracture surgery. Researchers will follow about 200 older adults for 90 days after their surgery. They will compare t…

This study aims to understand the types of patients who use a rehabilitation hospital in Ireland's Midwest region and track their recovery. Researchers will follow 100 adults during their stay, at discharge, and six months later to see how their ability to perform daily tasks, fr…

This study aims to understand the data from HeartMate 3 heart pumps to see if it can predict medical problems and improve patients' quality of life. Researchers will collect data from 150 adults who have received this specific pump, looking for patterns that might warn of issues …

This study aims to see if brief, simple tests measuring muscle strength, breathing, walking, and memory can predict which older adults (age 65+) are more likely to have complications after major abdominal surgery. Researchers will perform these tests during routine pre-surgery vi…

This study aims to understand how a specialized emergency unit for adults aged 75 and older affects their health. Researchers will follow 150 participants to see if this focused care reduces hospital admissions and improves their daily function and quality of life. They will chec…

This study aims to learn if ultrasound scans of a patient's thigh muscles can help doctors understand their nutritional status and predict how well they will recover after major surgery. Researchers will observe 50 patients in the intensive care unit (ICU), measuring their leg mu…

This study aims to understand how common and severe frailty is in patients undergoing a procedure to close a small pouch in the heart (left atrial appendage closure or LAAC). Researchers will follow 500 patients to see if being frail is linked to worse outcomes after the procedur…

This study aims to understand how chronic diseases like high blood pressure, diabetes, and frailty develop and progress in a rural Chinese county. Researchers will follow 20,000 adult residents for three years, collecting health data and samples to build a detailed picture of com…

This study aims to understand if older or frail adults are more likely to develop sudden kidney problems after non-heart surgery. Researchers will follow 515 patients to see if frailty is linked to this risk and if changes in blood pressure during the operation are the reason why…

This study aims to understand if a person's level of frailty before getting sick can predict their chances of survival and recovery from severe septic shock. Researchers will follow 200 adults aged 65 or younger who are admitted to intensive care with this life-threatening condit…

This study aims to understand if being frail makes it harder to survive an in-hospital cardiac arrest. Researchers will look at children who need emergency resuscitation (a 'code blue') to see if their level of frailty is linked to survival and recovery. The goal is to gather kno…

This study aims to understand how common frailty is among kidney transplant patients and whether it's linked to declining kidney function over time. Researchers will observe 80 transplant recipients at Alexandria University Hospitals, measuring frailty, nutrition, muscle strength…

This study aims to define a new concept called 'visual frailty' and create a tool to measure it. Researchers will gather information from 20 Scottish adults aged 60+ with advanced age-related macular degeneration (AMD). They will look at vision, reading ability, daily function, m…

This is a small, early-stage study to see if a nutritional supplement called beta-hydroxy-methylbutyrate (HMB) is practical and acceptable for older adults to use. Researchers will give the supplement to 25 people aged 65-85 with multiple chronic conditions for 12 weeks. The main…

This study aims to see if a simple blood test and brain scan results can predict which frail, elderly patients who need help with daily activities will visit the emergency room within six months. Researchers will measure a protein linked to Alzheimer's disease in the blood and as…