FRAILTY

This study tests a personalized strength exercise program for older adults (60+) who are at risk of losing function after a hospital stay. Participants do exercises at home designed to improve balance, walking speed, and strength. The goal is to prevent frailty and help seniors s…

This study is for adults with end-stage liver disease who are waiting for a liver transplant. It compares three approaches: a diet with protein spread evenly across meals plus exercise, a diet with protein mostly at one meal plus exercise, or standard advice. The goal is to see w…

This study looks at whether treating severe tricuspid valve leakage can improve kidney function, reduce swelling, and boost physical activity in older adults. About 100 participants will receive a valve repair procedure and be monitored for changes in kidney health, walking abili…

This study tests whether taking fecal microbiota transplants (FMT) in capsule form can reduce frailty and improve overall health in people aged 70-85. The researchers believe that restoring a healthy gut microbiome may slow aging and lower the risk of age-related diseases. The tr…

This study tests a prehabilitation program for adults aged 65 and older with breast cancer. The program includes exercise, nutrition advice, and a health assessment before surgery. The goal is to see if it helps maintain physical function and reduce complications. Researchers wil…

This study compares a multicomponent exercise program (combining strength, balance, and walking exercises) with a simple stretching and relaxation program in 60 nursing home residents who have frailty or dementia. The goal is to see if the exercise program improves physical funct…

This study looks at whether older adults (60+) with kidney failure who still produce some urine can safely start dialysis just twice a week instead of the usual three times. The goal is to see if fewer sessions lower hospital stays, falls, and other complications while maintainin…

This study tests a personalized treatment approach for people aged 65 and older who are newly diagnosed with multiple myeloma. The treatment plan is adjusted based on each patient's frailty level, aiming to improve response rates and reduce the chance of stopping treatment due to…

This study looks at whether adding occupational therapy and dietitian services to home-delivered meals can reduce fall risk in older adults who have trouble leaving home. About 750 people aged 60 and older will receive either meals alone, meals with dietitian support, meals with …

This study tests a simple scale that general practitioners can use to spot frailty in independent seniors over 65. Frailty means increased weakness and risk of falls or hospital stays. The goal is to catch it early so doctors can help patients stay healthy longer. About 740 peopl…

This study tests whether regular, structured conversations about health with a nurse or doctor can help people aged 67 to 84 stay healthier and live better. About 3,000 older adults in Sweden will take part, and researchers will track their quality of life, hospital visits, and h…

This study tests whether adding the drug tesamorelin to a home exercise program improves physical function in adults aged 50-80 with HIV who are sedentary and show early signs of frailty. Half of the 100 participants will get tesamorelin and half a placebo, all while exercising w…

This study tests a pre-surgery exercise program for frail adults who need chest surgery. The goal is to see if getting stronger before surgery helps people recover faster and have fewer problems after the operation. About 100 adults will take part.

This study tests a home-based recovery program for older, frail patients after colon cancer surgery. The program includes a health check, diet advice, and exercise guidance at home. Researchers want to see if this extra support helps patients recover better and feel healthier com…

This study tests whether a supplement called EGA® can help healthy adults aged 60 to 80 exercise longer. Participants will take either EGA® or a standard NMN supplement, then switch after a break. The main goal is to see how long they can cycle before getting tired, along with ot…

This study tests whether a supplement called MitoQ can improve blood vessel health, physical mobility, and thinking skills in frail older adults aged 65 to 80. Participants take MitoQ or a placebo for a period, and researchers measure changes in walking speed, memory, and blood f…

This study looks at how common frailty is in older adults with COPD and tests whether the Vivifrail exercise program can improve their physical abilities, daily activities, and quality of life. About 80 people aged 60 and older with stable COPD will take part. The program focuses…

This study tests whether a special egg white pudding can help improve nutrition and frailty in people with kidney failure who are on dialysis. About 54 adults will receive either the egg white pudding or a standard supplement after dialysis three times a week for 12 weeks. The go…

This study explores whether taking a daily polyphenol supplement (natural compounds found in plants) alongside a 12-week exercise program can help older adults build strength and physical function better than exercise alone. Researchers will recruit 40 people over 60 to test if t…

This study tests whether auricular acupressure (pressing small seeds on the ear) can help people aged 50 and older prepare for major lung surgery. The goal is to see if this simple technique improves appetite, energy, sleep, and reduces anxiety before the operation. Forty partici…

This study tests a mobile app called SUPERAGING that gives frail or pre-frail adults aged 60-90 personalized exercise, brain games, nutrition tips, and health management. The main goal is to see if people will use the app regularly and find it safe. About 40 participants will use…

This study looks at whether whole body vibration therapy, when added to usual care, can improve muscle mass, strength, and function in older adults. Forty people aged 65 and older with mild frailty will be randomly assigned to receive vibration therapy plus usual care or usual ca…

This study tests whether a special type of dynamic lighting can improve sleep, daily rhythms, and overall well-being in frail older adults (65+) who are in the hospital. Researchers will measure changes in melatonin levels and sleep patterns. The goal is to find a simple, non-dru…

This study tests whether high intensity interval training (HIIT) can reduce frailty and improve resilience in 200 older veterans aged 65 and up. Participants will do supervised exercise either at a center or at home. The goal is to see if this type of training boosts physical fit…

This study tests whether a daily movement program led by a kinesiologist can reduce frailty in 60 hospitalized heart patients (30 women). Frailty makes people weaker and more likely to have longer hospital stays or be readmitted. The program includes standing more, using resistan…

This study looks at whether a program of exercise, nutrition advice, and mental support before surgery (called prehabilitation) can help people with ovarian or endometrial cancer recover faster and feel better. About 64 patients will be randomly assigned to either standard care o…

This study tests whether a compound found in green tea, called EGCG, can reduce frailty and inflammation in older adults who have survived cancer. About 118 people aged 65 and older who have completed cancer treatment will take EGCG or a placebo for 12 weeks. The goal is to see i…

This study tests whether a structured, personalized care plan based on patient-reported symptoms can improve quality of life for adults with advanced cancer. About 120 participants will either receive standard palliative care or a tailored pathway that triggers specific support b…

This study looks at whether adding a frailty assessment to the usual risk score can better predict who might die within 90 days after hip fracture surgery. About 200 older adults (60+) having hip fracture surgery will have their frailty level measured when they arrive at the hosp…

This study looks at whether being frail before surgery raises the chance of kidney injury afterward. Researchers will track 1000 adults having non-cardiac surgery and measure blood pressure changes during the operation. The goal is to understand how frailty and blood pressure tog…

This observational study aims to define a new concept called 'visual frailty' in people aged 60 and older with advanced age-related macular degeneration (AMD). Researchers will measure vision, reading ability, mental health, and daily function to see how these factors relate. The…

This study looks at 200 older adults (65+) having hip fracture surgery to see if those who are frail have higher levels of inflammation. Researchers will use simple blood tests and a frailty questionnaire. The goal is to better understand the connection, not to test a new treatme…

This study aims to find out how common frailty is among people who have received a kidney transplant and whether frailty is linked to long-term kidney function decline. Researchers will assess frailty, nutrition, overall health, and muscle strength in 80 kidney transplant recipie…

This study tests whether a 12-week virtual exercise and education program is practical for people waiting for a kidney transplant. It will enroll 30 pre-frail or frail adults. The goal is to see how many people sign up, stick with the program, and complete follow-ups, not to meas…

This pilot study is testing whether a 12-week personalized nutrition supplement (beta-hydroxy-methylbutyrate) is practical and acceptable for adults aged 65 to 85. Researchers will measure how many people join and stick with the program, and also look at changes in strength, walk…

This study tests a new physical activity counseling method for older adults with early frailty. Researchers will compare it to the current approach used by physiotherapists. The goal is to see if the new method helps patients be more active and manage chronic conditions better. A…

This study looks at whether being frail (measured by a simple scale) increases the risk of death in adults aged 18 to 65 admitted to intensive care for septic shock. Researchers will follow 200 patients to see if frailty is linked to death within 28 and 90 days, longer hospital s…

This study aims to help older adults in Singapore stay healthy as they age. Researchers will screen 2,500 people aged 60 and older for early signs of decline in areas like memory, mobility, and mood. Those who need help will be offered community programs or doctor referrals. The …

This study follows 10,000 adults aged 18 and older for life to see if simple health measurements can predict how long and how well people age. Researchers will track deaths, diseases, and disabilities to find early warning signs. No treatments or drugs are tested—just observation…

This study looks at whether simple blood tests and brain scans can help predict which older adults with memory loss or frailty will need to visit the emergency room within six months. Researchers will follow 110 people over age 64 who have trouble with daily activities. The goal …

This study looks at how vegetarian and plant-based diets affect healthy aging in 5,000 middle-aged and older adults in Taiwan. Researchers will measure thinking skills, muscle mass, and strength to see if these diets help prevent age-related problems like frailty and memory loss.…

This study follows 150 adults aged 75 and older who receive care in a special emergency unit designed for seniors. Researchers will track whether this specialized care reduces hospital admissions and improves quality of life. The goal is to understand what works best for older pa…

This study is enrolling 20,000 adults in Taining County, China, to better understand common chronic diseases like high blood pressure, diabetes, and frailty. Researchers will collect health data and samples over three years to find patterns and risk factors. The goal is to create…

This study looks at whether a personalized care plan (PCP) can help older adults who are frail or at risk of frailty. Researchers will work with 600 people aged 60 and older to create and follow these plans over one year. The goal is to see if this approach is practical and impro…

This study follows 250 adults in the intensive care unit (ICU) to learn why some become frail and lose muscle. Researchers will track hospital stays, falls, and readmissions to find factors that can be changed. The goal is to identify targets for future treatments to help patient…

This study is for people aged 65 and older who are admitted to the intensive care unit (ICU). Researchers want to see if combining a blood test (CALLY index), a frailty score, and a severity score (SOFA-2) can better predict who might die in the ICU compared to standard methods. …

This study looks at whether ultrasound can help doctors understand the nutritional health of patients recovering from surgery in the intensive care unit. Researchers will measure muscle thickness and fat in the thigh, along with frailty and blood markers, and see how these relate…

This study will collect information from HeartMate 3 heart pumps in 150 adults to see if pump data can predict problems like bleeding, infection, or frailty. Researchers want to understand how pump readings relate to patients' quality of life and health outcomes. The goal is to h…

This study follows 100 adults admitted to a rehabilitation hospital in Ireland to see how their ability to perform daily activities changes from admission to discharge and 6 months later. Researchers will also track healthcare use and medication issues. The goal is to better unde…

This study explores whether frailty—a state of increased vulnerability—impacts the results of cardiopulmonary resuscitation (CPR) when a patient's heart or breathing stops. Researchers will track factors like the reason for the emergency, how long CPR lasts, and what equipment is…

This study looks at whether easy-to-do tests for muscle strength, breathing, and frailty can help predict complications after major abdominal surgery in people aged 65 and older. About 100 participants will complete these tests during a routine pre-surgery visit, and researchers …

This study looks at whether giving doctors a special geriatric assessment for their elderly patients with type 2 diabetes leads to better treatment decisions. About 220 people aged 60 and older will be randomly assigned to usual care or to have their doctor receive the assessment…

This study is testing whether a monthly monitoring program called ICOPE can help detect early signs of decline in people over 70 with multiple myeloma. The program uses digital tools like an app or chatbot to track health changes. The goal is to see if patients can stick with the…

This study is for adults having a procedure called left atrial appendage closure (LAAC) to lower stroke risk. Researchers want to see how frailty—a measure of weakness and health—affects recovery, complications, and quality of life. About 500 participants will be followed to trac…