FRAILTY

This study compares two treatment strategies for elderly frail patients with atrial fibrillation (AF) who are at high risk for both stroke and bleeding. One group receives catheter ablation plus a device to close the left atrial appendage (LAAO), while the other receives ablation…

This study is testing whether a year-long program of daily blueberries, protein powder, and three weekly exercise sessions can reduce frailty and lower the risk of heart disease in older adults. Researchers will enroll 240 people aged 65 and older in Nova Scotia. The goal is to s…

This phase 2 trial tests whether adding tesamorelin (a growth-hormone-releasing hormone analogue) to a home-based exercise program can improve physical function in 100 adults aged 50-80 with HIV. Participants are randomly assigned to receive tesamorelin or a placebo injection dai…

This study compares starting dialysis twice a week versus the standard three times a week in elderly patients (60+) with end-stage kidney disease who still produce some urine. The goal is to see if fewer sessions reduce hospitalizations, falls, and other complications while maint…

This study looks at whether eating protein evenly throughout the day, combined with a regular exercise program, can improve nutrition, muscle mass, and strength in people with end-stage liver disease awaiting a transplant. 90 participants will be split into three groups: one with…

This study tests whether a special egg white protein pudding can help people with kidney failure who are on dialysis. Participants will eat one pudding after each dialysis session, three times a week for 12 weeks. The researchers want to see if this is practical and if it improve…

This study looks at whether whole body vibration therapy, added to usual care, can improve muscle mass, strength, and function in older adults who are starting to become frail. About 40 people aged 65 and older will be randomly assigned to receive either vibration therapy plus us…

This study is testing whether adding registered dietitian counseling or occupational therapy home safety tips to regular home-delivered meals can reduce fall risk in older adults. Researchers will compare four groups: meals alone, meals plus dietitian, meals plus occupational the…

This study looks at whether a procedure to repair a leaky tricuspid heart valve can improve kidney function, reduce swelling, and boost physical activity in older adults. Researchers will follow 100 participants for changes in kidney health, walking ability, and daily function. T…

This study tests a personalized treatment plan for people aged 65 and older with newly diagnosed multiple myeloma. The treatment is adjusted based on each patient's frailty level to improve effectiveness and reduce side effects. About 131 participants will receive a combination o…

This study is testing whether taking fecal microbiota transplants (FMT) in capsule form can reduce frailty and improve overall health in people aged 70-85. The researchers believe that restoring a healthy balance of gut bacteria may slow aging and lower the risk of age-related di…

This study looks at whether regular, structured health discussions with a healthcare provider can help people aged 67 to 84 stay healthier and live better. About 3,000 participants in Sweden will be followed for six years to track quality of life, hospital visits, and lifestyle c…

This study tests whether a 4-week exercise program before surgery can reduce frailty and improve recovery in women with advanced ovarian cancer. Frailty affects about half of these patients and often leads to worse surgical outcomes and chemotherapy delays. The program includes l…

This study tests whether a daily movement program led by a kinesiologist can reduce frailty in 60 hospitalized heart patients. Frailty makes people weaker and more likely to have longer hospital stays or be readmitted. The program encourages simple activities like standing, walki…

This study tests whether a home-based exercise and nutrition program, called prehabilitation, can improve physical function in adults aged 65 and older with breast cancer before they have surgery. The program includes strength, balance, and flexibility exercises tailored to each …

This study looks at whether the Vivifrail exercise program can improve physical function and quality of life in older adults with COPD who are also frail. Researchers will enroll 80 participants aged 60 and older, giving half the exercise program and half standard care. The goal …

This study tests a 20-week home exercise program called STEP@Home for people aged 60 and older who are at risk of losing strength and function after a hospital stay. The program includes balance, walking, and strength exercises tailored to each person. Researchers will measure ph…

This study tests whether a special home-based program (ERAS 3.0) can help older, frail patients recover better after colon cancer surgery. The program includes a health check, diet advice, and exercise guidance at home. Sixty participants will be randomly assigned to either the p…

This study tests whether a program of exercise, nutrition advice, and mental support before surgery helps gynecological cancer patients recover faster and feel better. About 64 women with ovarian or endometrial cancer will be randomly assigned to either standard care or the preha…

This study tests whether a structured, symptom-driven care pathway improves symptom control and satisfaction for adults with advanced cancer receiving outpatient palliative care. 120 participants will be randomly assigned to either standard care or a tailored pathway that trigger…

This pilot study tests whether taking a daily polyphenol supplement (from red leaf lettuce) alongside a 12-week exercise program can improve physical performance in adults over 60. The main goal is to see if the study is feasible—can people stick with it? Researchers will also me…

This study tests whether a supplement called nicotinamide mononucleotide (NMN) can improve exercise tolerance in healthy adults aged 60 to 80. Participants will take either the supplement or a placebo and measure how long they can cycle before getting tired. The goal is to see if…

This study tests whether a 12-week exercise program, done twice a week, can improve physical function, thinking skills, and reduce fall risk in older adults living in nursing homes. The program includes strength, balance, and aerobic exercises. Researchers will compare it to a st…

This study tests whether a special type of artificial light that changes throughout the day can improve sleep, body clock function, and overall well-being in frail older adults. Researchers will enroll 300 people over age 65 who are staying in hospital rooms equipped with this dy…

This study tests whether a daily MitoQ supplement for 12 weeks can improve blood vessel function, walking speed, and thinking skills in frail older adults aged 65-80. Researchers will measure changes in blood flow, cognitive tests, and physical performance. The trial involves 60 …

This study looks at whether high intensity interval training (HIIT) can reduce frailty and improve resilience in older veterans. Researchers will enroll 200 veterans aged 65 and older who are not severely frail. Participants will do supervised and home-based HIIT exercises. The g…

This study tests whether a simple, non-invasive ear acupressure technique can help people aged 50 and older feel better and stronger while waiting for lung surgery. Participants will have small seeds placed on their ears and press them daily. The goal is to see if this approach i…

This study tests a smartphone app called SUPERAGING in 40 frail or pre-frail adults aged 60-90. For 16 weeks, the app provides personalized exercise, brain games, nutrition tips, and disease management. The main goal is to see if people will stick with the app and find it safe, n…

This study tests whether giving frail adults an Apple Watch and an exercise flipbook can help them get stronger before thoracic surgery. Researchers want to see if patients will use the device and follow the exercises. The goal is to improve recovery and reduce complications afte…

This pilot study tests whether a prehabilitation program combining strength exercises and reducing sitting time can improve fitness and recovery in frail adults aged 50+ scheduled for elective surgery. Fifty participants will be randomly assigned to the program or usual care. The…

This study investigates whether a protein called lumican, found in the blood, can identify postmenopausal women who have fragile bones but normal bone density scans. About 100 women will have their bone density, muscle strength, and blood lumican levels measured. The goal is to s…

This study looks at whether a simple frailty score can predict how well people aged 75 and older recover one year after emergency heart surgery. Researchers will track quality of life and survival in 265 participants over 12 months. The goal is to see if frailty, measured before …

This study investigates whether older adults with age-related hearing loss (presbycusis) can still hear and enjoy the sound of a crunchy biscuit while eating. Researchers will compare a crunchy biscuit with a soft one in 100 seniors aged 65 and older, asking them if they hear the…

This study aims to find the best way to deliver preventive health screenings to people in underserved and rural areas. It will compare different methods, such as interactive health reports, mobile screening units, and even droid-assisted screenings, to see which improves health e…

This study tests a low-burden screening tool to help doctors identify and manage functional impairment and frailty in veterans aged 60 and older. The goal is to improve quality of life and independence by catching problems early. Researchers will measure how well clinics adopt th…

This observational study will enroll up to one million adults to understand how health, environment, and lifestyle affect aging and disease. Researchers will link participants' clinical data with information from public records, such as pollution and social factors, to create a d…

This study is testing whether giving elderly patients with a broken hip and high frailty a special nutritional drink before surgery can help them stay more stable during the operation and recover better. Researchers will compare patients who get the drink with those who follow st…

This study will follow 1,000,000 adults aged 18 and older for the rest of their lives. Researchers will collect health measurements and track who develops diseases, becomes frail, or dies. The goal is to find which tests best predict how well people age, so doctors can one day of…

This study looks at whether having a mobility technician help older patients (65+) walk up to three times a day during their hospital stay can improve their strength and recovery. Researchers will compare these patients to those receiving usual care. The goal is to see if this si…

This study tests whether giving doctors a geriatric assessment—a quick check of frailty and function—helps them set safer blood sugar goals for patients aged 60+ with type 2 diabetes. 220 participants will be randomly assigned to usual care or to have their doctor receive the ass…

This study looks at whether ultrasound can measure muscle and fat in patients recovering from surgery in the intensive care unit. Researchers will track 50 patients, linking these measurements to their nutritional risk and how long they need a breathing machine. The goal is to fi…

This observational study looks at whether sarcopenia (muscle loss) and frailty affect how the muscle relaxant rocuronium works in older patients having surgery. Researchers will monitor 100 adults aged 65 and older to see how fast the drug takes effect and how long it lasts. The …

This study is for people aged 65 and older who are admitted to the intensive care unit (ICU). Researchers want to see if three simple health scores can predict the risk of dying in the ICU. The goal is to help doctors better understand which older patients need the most urgent ca…

This study looks at whether frailty—measured by a simple scale—can predict death in adults aged 18 to 65 admitted to intensive care for septic shock. Researchers will track 200 patients to see if those who are frail have a higher risk of dying within 28 days, even after accountin…

This study looks at whether older adults who are frail before hip fracture surgery have higher levels of inflammation, measured by simple blood tests. Researchers will enroll 200 patients aged 65 and older and check their frailty using a standard questionnaire. The goal is to bet…

This study tests a community-based program to screen and prevent decline in physical and mental abilities in 2500 older adults in Singapore. Participants will use digital tools to monitor their health, and those showing early signs of decline will get targeted support or referral…

This study is following 5,000 middle-aged and older adults in Taiwan who are Tzu Chi volunteers and eat plant-based or vegetarian diets. Researchers want to see if these diets are linked to healthier aging, including better memory, stronger muscles, and lower risk of frailty. Par…

This study follows 1,000 adults having non-cardiac surgery to see if being frail before the operation increases the chance of acute kidney injury afterward. Researchers will also check if changes in blood pressure during surgery help explain this link. The goal is to better under…

This study looks at whether measuring frailty—a person's overall physical weakness—can improve predictions of death within 90 days after hip fracture surgery. Researchers will follow about 200 older adults who have surgery for a broken hip. They will compare the standard risk sco…

This study is for adults having a procedure called left atrial appendage closure (LAAC) to reduce stroke risk. Researchers want to see how frailty—a measure of weakness and health—affects recovery, complications, and quality of life. About 500 participants will be followed over t…

This observational study seeks to define a new concept called 'visual frailty' in people aged 60 and older with advanced age-related macular degeneration (AMD). Researchers will measure vision, reading ability, mental health, and daily function in 20 participants to develop a vis…

This study tests a new physical activity counseling method for older adults with early frailty. Researchers will compare it to the current approach used by physiotherapists. The goal is to see if the new method helps patients spend more time in moderate or vigorous activity each …

This study tests whether a 12-week personalized nutrition supplement (beta-hydroxy-methylbutyrate) can improve physical function in adults aged 65-85 with frailty and multiple chronic conditions. The main goal is to see if the study procedures are feasible and acceptable to parti…

This study follows 250 adults in the ICU to understand frailty and muscle wasting. Researchers will use ultrasound, blood tests, and questionnaires to track changes. The goal is to find factors that can be changed to improve recovery and reduce long-term disability.

This study looks at whether a personalized care plan (PCP) can be successfully used for older adults with frailty. The plan is created with input from the patient and a team of healthcare providers. Researchers will track how many plans are completed after one year. The goal is t…

This study looks at whether easy, quick tests for frailty and muscle strength can help predict complications after major abdominal surgery in adults aged 65 and older. About 100 participants will do brief assessments during a routine pre-surgery visit, and researchers will check …

This study follows 100 adults admitted to a rehabilitation hospital in the Midwest of Ireland. Researchers will measure how well patients recover daily living skills and track their use of healthcare services after discharge. The goal is to understand what helps or hinders recove…

This study will follow 20,000 adults in rural China for three years to understand how chronic diseases like high blood pressure, diabetes, and frailty develop. Participants will provide health data and samples to build a comprehensive database. The goal is to create better diseas…

This study tests whether a monthly monitoring program (ICOPE) can help detect early signs of decline in people over 70 with multiple myeloma. The goal is to prevent loss of independence. About 30 participants will use a digital app or chatbot for one year to track their health.

This study looks at data from the HeartMate 3 heart pump to see if it can help predict problems like bleeding, infection, or frailty in people with advanced heart failure. Researchers will track 150 adults getting the pump and compare pump alarms and readings to their health over…

This study looks at whether a blood test for a protein called p-tau181 and brain scans can predict which elderly patients with dementia, frailty, and loss of independence will need to visit the emergency room within six months. Researchers will follow 110 participants and track E…

This study tests whether a 12-week virtual exercise and education program is practical for people with end-stage kidney disease who are waiting for a transplant. About 30 participants will either do the program or receive usual care. The main goal is to see if enough people join,…

This study follows 150 adults aged 75 and older who visit a special emergency unit designed for seniors. Researchers want to see if this dedicated care reduces hospital admissions and improves quality of life. Participants will be tracked for outcomes like function, repeat ER vis…

This study looks at how frailty—a state of increased weakness—impacts the results of CPR in patients who need emergency resuscitation. Researchers will track factors like the reason for the emergency, how long CPR lasts, and what equipment is used. The goal is to better understan…

This study will check how common frailty is in 80 people who have received a kidney transplant. Researchers will use simple tests like walking speed and grip strength to measure frailty. They want to see if frailty is linked to long-term kidney function problems.