FRAILTY

This study tests whether a combination of resistance-based exercise and nutritional supplements (protein and vitamin D) can improve physical function and reduce the risk of disability in older adults living in rural China. Participants are 60 years or older and show early signs o…

This study tested whether a structured program combining exercise, nutritional advice, and psychological support is safe and doable for frail adults with cirrhosis waiting for a liver transplant. Twenty-five participants were enrolled to see if they could stick with the program a…

This study looked at whether it is safe to reduce blood pressure medication in frail older adults living in long-term care. Researchers enrolled 522 residents with low blood pressure and tested a gradual medication reduction plan. The goal was to see if this approach could lower …

This completed phase 3 trial tested whether a lifestyle program (diet and exercise) plus the drug metformin could reverse frailty and sarcopenic obesity in 114 older veterans aged 65-85. Participants followed a weight-loss diet and exercised three times a week, while taking metfo…

This study tested a digital system called SAIF designed to assess and reduce frailty in older adults. 105 people aged 60 and older who were vulnerable or mildly frail used the system at least 2-3 times per week for up to 20 minutes per session. The goal was to see if SAIF could h…

This study tested a home exercise program called STEP@Home for older adults who are starting to become frail. The program includes balance, strength, and aerobic exercises done three times a week for 20 weeks. Researchers enrolled 40 people aged 60 and older who were discharged f…

This study tested how accurate and reliable two digital devices are at measuring hand grip strength and muscle fatigue in older adults. Over 400 people aged 60 and older participated. The goal is to improve diagnosis of conditions like sarcopenia and frailty.

This study tested a six-month home-based exercise program using elastic bands to prevent frailty in 120 adults aged 50-85 with type 2 diabetes and chronic kidney disease. The program aimed to improve muscle strength and daily functioning. Researchers measured changes in frailty s…

This study tested a personalized training program designed to prevent functional decline in frail older adults who are not yet disabled. 80 participants aged 65 and older were split into two groups: one received the personalized training, and the other received standard care. The…

This study tested a program that combines diet advice, exercise, medication review, and social support to prevent frailty in older adults who are at risk. 232 people aged 70 and older took part. The goal was to see if this approach could help them stay stronger and more independe…

This study tested whether a simple home exercise program and protein supplements, alone or together, could help prevent falls in seniors at risk of muscle loss (sarcopenia). Over 800 older adults with early signs of frailty or a recent fall took part. They were assigned to do str…

This study tested a special educational program designed to prevent and treat frailty in older adults living in the community. Researchers enrolled 235 people aged 65 and older who were already frail or at risk of becoming frail. The program aimed to teach healthy habits to help …

This study tested whether clazakizumab, an anti-inflammatory drug, could improve walking speed and reduce disability in older adults with frailty. 29 participants aged 70 and older received either the drug or a placebo every 4 weeks for 24 weeks. Researchers measured walking spee…

This study tested a home-based physical therapy program called LIFT for people with liver cirrhosis waiting for a transplant. The program included a personalized exercise plan, a smartphone app to track progress, daily text reminders, and regular phone check-ins. The goal was to …

This study tested whether a 12-week home-based walking program could help heart failure patients with depression, frailty, and quality of life. 68 patients were split into two groups: one got standard health education, the other added a walking routine of 3,000 extra steps per se…

This pilot study tested whether taking a green tea extract (EGCG) plus vitamin C daily for 12 weeks is safe and feasible for older cancer survivors who are frail or pre-frail. The study enrolled 24 people aged 65 and older who had completed cancer treatment. The main goal was to …

This study tested a nurse-led education program for dry mouth in 70 patients with life-limiting conditions or frailty. Nurses used guidelines to discuss causes and treatments with patients, creating a personalized plan. The goal was to see if this approach reduces dry mouth sever…

This completed study tested a structured music improvisation program for older adults with mild to moderate dementia and their caregivers. Seven participants took part in three-hour sessions led by professional musicians. The goal was to see if this non-drug approach could improv…

This study looked at whether a 12-week program combining strength training with Taiwanese opera activities can help adults aged 65 and older stay physically fit and delay frailty. 120 community-dwelling seniors in Taipei took part, with half doing the program and half continuing …

This study tested a 12-week exercise program called Vivifrail in 80 elderly residents of long-term care facilities. Participants did physical training five times a week for about an hour. Researchers measured changes in physical performance, fall risk, grip strength, and overall …

This study tested whether the Ghostly app, which guides patients through strength exercises, could help hospitalized people with stroke, COVID-19, frailty, or muscle weakness. Fifteen participants used the app during their hospital stay. The goal was to see if it was practical an…

This study tested a special home rehab program for older adults (65+) to help them do everyday tasks like bathing and dressing more easily. 47 people took part, and the program was added to their usual home health therapy. The goal was to see if the extra help improved their moto…

This study tested whether playing hemsball, a ball game, could help older men improve their balance, reduce fear of movement, and lower frailty. Eighty-six men aged 65 and older played hemsball for 8 weeks. Results showed better balance, less fear of movement, and reduced frailty…

This study tested whether a program combining personalized exercise sessions and protein supplements is practical for older adults recovering in skilled nursing facilities after a hospital stay. Fifty participants aged 65 and older with mild frailty or worse were enrolled. The ma…

This study tested a 10-week program that combines resistance exercises with cognitive tasks (like memory games) in 38 frail older adults with chronic musculoskeletal pain. The goal was to see if the program is feasible and can improve frailty and thinking skills. Participants wer…

This pilot study tested a program called DAPPER for African American women aged 50 and older who have pain, depressive symptoms, and trouble moving around. Participants received 8 nurse visits at home to help manage their pain and mood. The study aimed to see if the program could…

This small pilot study tested whether combining active video games (exergaming on Nintendo Switch) with resistance training could improve frailty in 30 nursing home residents. Participants played sports games like badminton, tennis, and soccer while also doing strength exercises.…

This study tested whether interactive physical therapy (using computer-based balance and strength exercises) could help frail older adults recover better after open heart surgery. 153 participants aged 65 and older were assigned to either multicomponent training or computer-based…

This study tested how willing healthy seniors aged 80 and older are to use connected health devices like scales, activity trackers, and blood pressure monitors at home. 34 participants used the devices while researchers measured their comfort and acceptance through questionnaires…

This study looked at 142 adults in the intensive care unit (ICU) to see if being frail or very sick before admission leads to higher hospital costs. Researchers used medical records to measure frailty and illness severity, then compared them to the total cost of care. The goal wa…

This pilot study tested whether a 3-month program combining group exercise, medication review, and nutrition workshops could be practically delivered in primary care for frail adults over 65. Researchers recruited 32 participants from two health centers and tracked feasibility, s…

This study looked at whether smell training and/or physical exercise can improve thinking, movement, and quality of life in healthy adults aged 60 and older. About 120 participants were split into four groups: usual care, smell training, exercise, or both. The goal was to underst…

This study looked at whether common early warning scores can predict which older patients (65+) are at risk of dying within 28 days after visiting the emergency room. Researchers tracked over 2,700 patients, recording vital signs, lab results, and frailty. The goal was to see whi…

This study looked at 85 older adults in Spain to see if ultrasound scans and blood tests can help measure muscle quality and frailty. Some participants did a 16-week exercise program. The goal was to find better ways to track frailty and muscle loss without complicated procedures…

This study tracked 295 adults who had high-risk surgery for stomach, esophagus, pancreas, or liver cancer. Researchers measured quality of life before surgery and again at 6 and 12 months after. They also asked patients and their family members if they regretted the decision to h…

This study examines whether frailty and simple blood tests can predict which patients aged 80 and older are most likely to die within 30 days after major abdominal surgery. Researchers will review records of 100 patients to see if a frailty index and lab markers like albumin and …

This study looked at 200 older adults (65+) having planned surgery for colorectal cancer. Researchers used a frailty test before surgery to see if it could predict complications like infections or longer hospital stays. The goal is to help doctors better plan care and reduce risk…

This study looked at whether a frailty index (a score based on health problems) can predict the risk of dying within one year for older adults (65+) who receive hospital-level care at home. Researchers followed 2,610 patients and compared the frailty score to another common measu…

This study explored why some people with COPD lose muscle mass and strength (sarcopenia). Researchers measured exercise ability, frailty, and breathing in 42 adults with COPD. The goal was to find which factors most affect muscle loss, helping guide future care.

This study looked at 58 frail elderly patients (65+) to find the best dose of remimazolam, a sedative used for anesthesia. Researchers used a special monitor to track breathing and adjusted doses carefully. The goal is to help doctors give just enough medicine to put patients to …

This study looked at 79 older adults with hip fractures to see if the balance of specific muscles around the hip affects the type of fracture. Researchers used CT scans to measure muscle areas and found that regional muscle balance may be more important than overall muscle loss. …

This study looked at whether two simple frailty questionnaires (G8 and VES-13) can predict serious side effects from chemotherapy in people 65 and older with gastrointestinal cancers. Researchers followed 72 patients receiving standard chemotherapy and checked their frailty, nutr…

This study looked at 164 adults aged 65 and older who had a colonoscopy with sedation. Researchers compared two common sedatives—propofol and dexmedetomidine—to see how they affected thinking and memory. They also checked whether frailty played a role. Participants took a simple …

This study surveyed 47 older adults (65+) at a frailty clinic in France to learn about their use and understanding of cannabidiol (CBD). The goal was to gather information to help guide safe CBD use and prevent potential side effects in this age group. No treatment was given; it …

This pilot study tested whether an adapted version of cognitive stimulation therapy (CST) is acceptable and feasible for stroke survivors who are pre-frail. Ten stroke survivors and their carers took part in focus groups to share their experiences. The goal was to see if CST coul…

This study looked at whether frailty can predict who survives cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers analyzed data from over 200,000 adults admitted to intensive care units across South Korea. They found that …

This pilot study tested whether a multi-component prehabilitation program—including physical therapy, nutrition counseling, and meditation—is feasible for older adults (70+ or 65+ with high risk) scheduled for major elective surgery. The program aimed to improve strength and reco…

This small, completed study looked at the link between gut bacteria and frailty in 14 older adults. Participants collected stool samples at home and took part in a 12-month healthy aging education program. The goal was to see if changes in gut microbes relate to physical function…

This study followed 211 older adults who were hospitalized with COVID-19 to see how their mobility and daily function changed over time. Researchers measured physical abilities like walking, balance, and thinking skills. The goal is to understand recovery patterns so doctors can …

This completed study looked at how the COVID-19 pandemic changed the health and daily lives of people aged 75 and older and their caregivers. Researchers analyzed medical records and interviewed participants to understand the impact of lockdowns, reduced physical activity, and so…