FRAILTY

This study tests a personalized management program for 115 older adults with frailty. The program includes exercise, nutrition advice, and medical adjustments, starting with a short hospital stay and continuing at home for 6 months. Researchers measure changes in daily function a…

This Phase 2 trial tests whether a combination of dasatinib and quercetin (D+Q) can safely improve physical function in 82 older adults with HIV who are frail or prefrail. Participants take D+Q or a placebo in six 2-day cycles over 12 weeks, then are monitored for another 12 week…

This study tests whether adding creatine and HMB supplements to a supervised exercise program can improve physical function, muscle mass, thinking skills, and quality of life in frail older adults living in nursing homes. Fifty people aged 65 and older are taking part, receiving …

This study tests whether monthly transfusions of plasma from young, healthy donors can safely reduce frailty and improve immune function in older adults aged 55-95. Thirty participants will receive 12 transfusions over a year and be followed for another year. The goal is to see i…

This study tests whether a team of specialists working together can improve outcomes for frail Veterans having elective surgery. About 35,000 Veterans at three VA hospitals will be randomly assigned to usual care or a multidisciplinary board that reviews each case and makes perso…

This study looks at whether reducing the number or dose of medications in people aged 80 and older can improve their health and independence. Researchers will work with primary care providers to safely lower doses of common drugs like those for blood pressure or pain. The goal is…

This study looks at 80 people with heart failure to find better ways to diagnose sarcopenia, a condition where muscles weaken and shrink. Researchers will use body scans, blood tests, and simple physical tests like walking speed and grip strength. The goal is to catch muscle loss…

This study tests whether a 12-week program led by nursing and sports science students can improve frailty in older adults living in nursing homes. Sixty participants will be randomly assigned to either the program or usual care. The program includes physical exercise and occupati…

This phase 2 trial tests whether a daily dose of EGCG, a compound found in green tea, can reduce frailty and inflammation in people aged 65 and older who have survived cancer. About 118 participants will take either EGCG or a placebo for 12 weeks. The study is currently suspended…

This study looks at whether a tailored exercise program before ventral hernia repair can improve recovery in frail patients aged 65 and older. Participants will wear activity monitors to track their movement levels. The goal is to see if being more active before surgery leads to …

This study tests a voice-activated app called EngAGE that lets care partners send encouraging messages to frail, homebound older adults. The goal is to see if this simple technology can improve physical function (like standing up from a chair) and reduce loneliness. The study inv…

This study looks at whether exercise sessions—either in person or through video calls—can improve frailty, mental health, and physical function in adults aged 65 and older living in rural areas. About 240 participants will be split into two groups: one does multicomponent exercis…

This study tests two short-term drug regimens—dasatinib plus quercetin, or fisetin alone—in 110 adult survivors of childhood cancer who are frail. The goal is to see if these 'senolytic' drugs can clear aging cells, improve walking speed, and reduce frailty. It is a first-of-its-…

This study tests a two-part virtual program for teens aged 13-18 with Fontan physiology, a type of single-ventricle heart disease. The first part is a small-group wellness education session each week for 5 weeks, led by a psychologist. The second part is a personalized home exerc…

This study tests a virtual, at-home exercise program for adults with Fontan circulation, a type of heart condition. The goal is to see if the program can reduce frailty and improve exercise ability. About 53 participants will use a telemedicine program to exercise at home. The st…

This study tests whether a personalized care plan, based on a geriatric assessment, can reduce severe side effects in older adults (65+) starting chemotherapy for common cancers. Participants are randomly assigned to receive the assessment-driven plan plus usual care, or usual ca…

This study looks at whether low-resistance exercise (like light strength training) can safely help people with pulmonary arterial hypertension (PAH) feel better and be less frail. About 20 adults with stable PAH will try the program. Researchers will track safety, how well people…

This study tests whether eating only within a 10-hour window each day can help prevent frailty in people over 55 who are on hormone therapy for prostate cancer. Frailty makes it harder to recover from stress and can lead to loss of independence. The trial will enroll 30 participa…

This study tests two walking programs in 60 older adults who are at risk of becoming frail. One group will gradually replace 30 minutes of sitting with one long walk, while the other will do three short walks spread throughout the day. Researchers want to see which approach is ea…

This study tests whether a combination of exercise, fruit, and vitamin supplements can reduce frailty in older adults aged 65 to 80. About 934 participants with low physical activity and low fruit intake will be split into two groups: one receives the combined intervention three …

This study looks at whether the P-POSSUM score, a tool used to predict surgical risks, can accurately forecast complications and death after abdominal surgery in patients aged 60 and older. Researchers will also check if adding a frailty assessment improves predictions. The study…

This study asks 10 young adult survivors of childhood cancer to watch exercise videos and share their thoughts. The goal is to adapt the videos so they feel more relatable and useful for other survivors. Researchers will use interviews and a questionnaire to understand what works…

This study examines whether the COVID-19 pandemic increased frailty and muscle loss (sarcopenia) in people waiting for a liver transplant. Researchers will compare data from 208 patients assessed before and during the pandemic. The goal is to understand how the pandemic affected …

This study tests a personalized care model called TIME for frail older adults receiving home care. The goal is to prevent health crises and avoid emergency hospital visits. Researchers will compare outcomes between those receiving the new model and those receiving standard care, …

This study looks at whether a computer model can predict heart injury after major orthopedic surgery in patients 65 and older. Researchers will combine blood tests, frailty scores, and other health data to build a machine learning tool. The goal is to help doctors spot high-risk …

This study looks at 400 adults with a small bowel blockage in the emergency department. It checks if placing a tube through the nose into the stomach actually helps with pain and recovery. The study also examines how frailty affects outcomes in older patients.

This study tests whether smart devices and a habit-coaching app can help older adults (65+) stay active and healthy. Thirty participants will use a smartwatch and sleep mat with either a personalized coaching app or a standard app, or just receive an education leaflet. The goal i…

This study looks at how to improve the pre-surgery checkup process for older adults having major abdominal surgery. Researchers will observe clinic visits and interview patients, caregivers, and healthcare providers to find what works well and what could be better. The goal is to…

This study tests a nurse-led program called INFA that screens frail older adults (age 65+) in the hospital for issues like falls, confusion, and malnutrition. Based on the screening, nurses start simple treatments and refer complex cases to a geriatric team. The goal is to see if…

This study follows 1,800 adults with reduced kidney function (not on dialysis) to see how nutrition and lifestyle affect their health. Researchers will track changes in kidney function, heart health, bone health, and thinking skills over time. The goal is to find better ways to m…

This study follows over 19,000 older adults who previously took aspirin in a clinical trial. Researchers are monitoring them for delayed effects on cancer, dementia, disability, and death. The goal is to see if aspirin has any long-term benefits or risks years after stopping the …