FRAILTY

This study is testing whether a combination of exercise, eating more fruit, and taking vitamin supplements can help prevent muscle loss and reduce frailty in older adults. It involves about 934 people aged 65-80 who are not very active and don't eat much fruit. Participants in th…

This study aims to understand how personalized nutrition and lifestyle management can help people with declining kidney function stay healthier and slow disease progression. Researchers will follow 1,800 adults with reduced kidney function (not on dialysis) for up to ten years, t…

This study is testing whether a structured home exercise program, delivered through video calls, can help adults with a rare heart condition called Fontan circulation become less frail and improve their strength and endurance. The program aims to make exercise training more acces…

This study is testing a new hospital program designed to better identify and support frail older adults. The program involves nurses screening for common health issues in seniors and creating a personalized care plan. Researchers want to see if this approach helps patients mainta…

This study is testing whether it's practical to run a larger trial using digital tools to help older adults adopt healthier habits. It involves 30 people aged 65+ in London who are starting to feel less robust. Participants will use smartwatches and apps for 3-6 months, or receiv…

This study is testing a personalized care plan designed to help older adults with cancer better handle chemotherapy. The plan uses a questionnaire to identify individual health risks and then suggests specific support, like nutrition advice or physical therapy. Researchers want t…

This small pilot study is testing whether a 12-week exercise and activity program before elective surgery can help older adults who are frail. The program combines strength training with advice to reduce sitting time, aiming to improve patients' strength and fitness so they can r…

This study is testing a new team-based care model for frail Veterans scheduled for elective surgery. At three large VA hospitals, Veterans identified as frail will have their case reviewed by a special board of doctors and specialists from different fields before surgery. The goa…

This study is testing whether a personalized care plan can help prevent health crises for frail elderly people living at home. It involves 150 participants across 30 municipalities who receive home care services and are at high risk for needing emergency care. The goal is to see …

This study is testing two different drug combinations to see if they can reduce the number of 'aged' cells in the body and improve physical frailty in adults who survived childhood cancer. The trial will involve about 110 participants who are already experiencing frailty. Researc…

This study is testing if carefully lowering the doses of many common medications helps people aged 80 and older stay healthier. Doctors will work with 1,800 patients who take six or more daily pills to find the lowest effective dose for each one. The goal is to see if this approa…

This study is testing two different walking programs to help older adults at risk of frailty reduce their sitting time. Researchers want to see if replacing 30 minutes of daily sitting with either one 30-minute walk or three 10-minute walks is easier to stick with over 60 days. T…

This study is testing if a specific eating pattern can help prevent frailty in older men undergoing hormone therapy for prostate cancer. Researchers will compare a 12-week program of time-restricted eating (eating all meals within a set daily window) to a regular diet. The goal i…

This study aims to update existing exercise videos originally made for older adults so they are more suitable for adult survivors of childhood cancer. Researchers are asking 10 survivors to watch the videos and provide feedback in interviews. The goal is to create a helpful tool …

This study is testing whether a weekly group program combining strength training with Taiwanese opera activities can help older adults in Taipei stay physically fit and delay frailty. About 120 participants aged 65 and over will attend 12 weeks of sessions focused on building mus…

This study is testing whether a voice-activated app called EngAGE can help frail, homebound older adults improve their physical strength and social connections. It compares the app to standard paper exercise handouts. The goal is to see if using technology to guide exercises at h…

This study is testing whether a combination of two drugs, dasatinib and quercetin, can improve physical function in older adults with HIV who are experiencing frailty or early signs of frailty. The trial involves 82 participants aged 50+ who have had HIV for at least 10 years and…

This study is testing whether a 12-week program of simple, low-resistance exercises done at home is safe and can help improve daily life and physical ability for people with pulmonary arterial hypertension (PAH), a serious lung condition. Researchers are enrolling 20 adults with …

This study is testing a virtual wellness program for teenagers with a complex heart condition called Fontan physiology. The program combines group education with personalized home exercises to see if it can reduce frailty, increase physical activity, and improve quality of life. …

This study is testing if a monthly injection that lowers inflammation can help older adults walk faster, feel less tired, and think more clearly. About 60 adults aged 70 and older with mild mobility issues and higher inflammation levels will receive either the real drug or a plac…

This study is observing over 19,000 older adults who previously participated in an aspirin trial to see if there are any delayed health effects years after stopping the medication. Researchers are primarily watching for long-term impacts on cancer, dementia, heart disease, and ph…

This study aims to understand why people with heart failure often lose muscle mass and strength, a condition called sarcopenia. Researchers will study 80 participants, comparing those with heart failure to healthy individuals. They will use blood tests, body scans, and fitness as…

This study aims to understand how vegetarian and plant-based diets affect health as people get older. It will follow 5,000 middle-aged and older volunteers in Taiwan for years, tracking their diet, physical strength, and memory. The goal is to gather evidence to help create bette…

This study aims to understand and improve the process of checking older adults' overall health before major abdominal surgery. Researchers will observe clinic visits and interview patients, caregivers, and healthcare staff to create a detailed map of the current system. Then, the…