FRAILTY

This study tests a program called INFA that helps frail older adults (65+) who are in the hospital for non-geriatric reasons. Nurses use a special checklist to find health issues early and create a personal care plan. The goal is to help patients keep their ability to do daily ta…

This study tests a personalized care plan for older adults (65+) starting chemotherapy. The plan uses a questionnaire to identify risks like frailty or other health issues, then guides doctors to adjust care. The goal is to see if this approach can lower severe side effects and h…

This study tests whether giving older, frail adults monthly transfusions of plasma from young, healthy donors is safe and can improve their immune health, thinking, and quality of life. Thirty people aged 55 to 95 with signs of frailty will receive 12 monthly treatments and be fo…

This study tests whether a team of specialists working together can improve care for frail Veterans before elective surgery. About 35,000 Veterans at three VA hospitals will be randomly assigned to either usual care or a special team meeting (PAUSE Board) that creates a personali…

This study looks at whether a program of exercise, fruit, and vitamin supplements can reduce frailty in older adults aged 65 to 80. About 934 people with low activity and low fruit intake will take part. Some will do group exercise and eat fruit with vitamins three times a week f…

This study tests whether a combination of two drugs, dasatinib and quercetin (D+Q), can safely improve physical function in people aged 50 and older with HIV who are frail or prefrail. About 80 participants will receive either D+Q or a placebo over 12 weeks, then be monitored for…

This study looks at whether reducing the number and dose of medications can improve health for people aged 80 and older who take 6 or more daily pills. Doctors and nurse practitioners will work with patients to safely lower doses or stop unnecessary drugs. The goal is to see if t…

This study tests whether a drug called Clazakizumab can improve walking speed and reduce disability in older adults with chronic inflammation. About 29 people aged 70 and older will receive either the drug or a placebo every 4 weeks for 24 weeks. Researchers will measure walking …

This study looks at whether older adults at risk of frailty can replace 30 minutes of sitting with light walking each day. Participants are split into two groups: one does one 30-minute walk, the other does three 10-minute walks. Researchers want to see which approach is easier t…

This study tests a virtual, at-home exercise program for adults with Fontan heart physiology, a condition where the heart has a single pumping chamber. The goal is to see if the program can reduce frailty and improve exercise capacity. About 53 participants will use a telemedicin…

This study looks at whether taking creatine and HMB (a protein-like supplement) along with a supervised exercise program can improve physical function, muscle mass, thinking skills, and quality of life in frail older adults living in nursing homes. Fifty people aged 65 and older …

This study looks at whether a tailored exercise program before hernia surgery can improve recovery in frail patients aged 65 and older. Participants will wear activity monitors and complete surveys about their quality of life. The goal is to see if being more active before surger…

This study tests whether a voice-activated app called EngAGE can improve physical and social function in frail, homebound adults aged 60 and older with at least two chronic conditions. Participants use the app at home to guide exercises and social activities, and researchers comp…

This study looks at whether low-resistance exercise training is safe and can improve frailty and quality of life in people with pulmonary arterial hypertension (PAH). About 20 participants will do gentle exercises and be monitored for side effects, satisfaction, and physical func…

This study is testing two different drug combinations to see if they can reduce frailty and markers of cellular aging in adults who survived childhood cancer. Researchers will measure if participants can walk faster and if certain aging markers in their blood decrease after takin…

This study is testing a virtual wellness program for teenagers with Fontan physiology, a complex heart condition. The program combines group education with personalized home exercise plans to see if it can improve resilience, reduce frailty, and increase daily activity. Researche…

This study asks childhood cancer survivors aged 18-39 to review and give feedback on exercise videos. The goal is to make the videos more relatable and useful for survivors. The study does not test a treatment but aims to improve future physical activity programs.

This study follows over 19,000 older adults who previously took aspirin in a clinical trial. Researchers are monitoring for long-term effects, especially on cancer, dementia, and disability. No new treatment is given—participants just continue regular check-ups and phone calls to…

This study explores whether using smart devices and health apps can help adults aged 65 and older adopt healthier habits. Thirty participants will either use a special 'Healthy Habits' app with coaching, a standard app, or receive an education leaflet. The goal is to see if this …

This study looks at whether eating only during certain hours of the day (time-restricted eating) can help prevent frailty in people over 55 who are on hormone therapy for prostate cancer. Frailty means losing strength and independence. The study will test if this eating pattern h…

This study tests a personalized care model (TIME) for frail older adults receiving home care. The goal is to prevent or reduce crises that could lead to hospitalization. 150 participants will be followed for 6 months to see if the model helps them achieve their personal goals and…

This study follows 1,800 adults with reduced kidney function (not on dialysis) to see how nutrition affects overall health and disease progression. Researchers will track heart health, bone health, thinking skills, and daily function using hospital records and a mobile app. The g…

This study looks at whether a program of strength exercises and reducing sitting time before elective surgery can help frail patients recover more quickly. Researchers will measure walking speed, physical activity, and complications after surgery. The study includes 50 adults age…

This study looks for better ways to detect muscle loss (sarcopenia) in people with heart failure. Many heart failure patients also have muscle loss, which makes their condition worse. Researchers will measure muscle mass, strength, and walking speed in 80 adults aged 50 and older…

This study looks at whether placing a tube through the nose into the stomach (nasogastric tube) is truly helpful for adults with a small bowel blockage in the emergency room. Researchers will track pain, nausea, hospital stay length, and survival in 400 patients. They will also c…

This study looks at how a special clinic helps older adults get ready for major abdominal surgery. Researchers will watch and talk to doctors, staff, and patients to understand what works well and what could be better. The goal is to create a clear plan that other hospitals can u…