Can young blood reverse aging? new trial tests monthly plasma transfusions

NCT ID NCT03458429

ENROLLING_BY_INVITATION Disease control Sponsor: Dipnarine Maharaj Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether monthly transfusions of plasma from young, healthy donors can safely reduce frailty and improve immune function in older adults aged 55-95. Thirty participants will receive 12 transfusions over a year and be followed for another year. The goal is to see if this approach can improve quality of life, thinking skills, and overall health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Plasma from young donors treated with G-CSF
What this could lead to: If it works, this could point toward a treatment that reduces frailty and strengthens the immune system in older people.
What could go wrong: This is an early-phase trial with only 30 participants, so results may not apply widely. There are also risks from monthly transfusions, such as allergic reactions or infections.

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Conditions

The condition(s) this trial relates to.

Frailty

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FRAILTY

Contacts and locations

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Locations

South Florida Bone Marrow/Stem Cell Transplant Institute DBA Maharaj Institute of Immune Regenerative Medicine

Boynton Beach, Florida, 33437, United States

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