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Centenarians put to the test: can exercise reverse frailty at age 100?

NCT ID NCT07723339

Symptom relief Sponsor: Fundacion Miguel Servet Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 23, 2026 · Last updated Sep 02, 2026 · Updated 3 times

Summary

This trial tests whether a home-based exercise program tailored to people aged 100 and older can improve physical function, balance, and quality of life. Participants will follow a personalized routine of strength, balance, and aerobic exercises with regular check-ins. The study aims to see if even at very advanced ages, targeted movement can make a meaningful difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
an individualized multicomponent physical exercise program including strength, balance, flexibility, and mobility training
What this could lead to
If it works, this could point toward a practical way to preserve mobility and independence in the oldest old.
What could go wrong
The trial is small (60 participants) and limited to relatively healthy centenarians, so results may not apply to frailer individuals. Exercise carries a low risk of falls or injury.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2026

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

100 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individuals aged ≥ 100 years; * Residents of Navarre.; * Barthel Index score ≥ 60, capable of standing and performing transfers independently or with minimal assistance; * Stable clinical condition; * Ability to follow simple instructions; * Signed informed consent (by the participant or legal representative). Exclusion Criteria: * Acute illness or unstable chronic condition, clinical decompensation within the last month: hemodynamic instability, acute pathology, hospitalization; * Severe cardiovascular or respiratory pathology that contraindicates exercise; * Severe cognitive impairment preventing participation; * Recent fracture or major surgery (\< 3 months). * Individuals in an end-of-life situation, defined as a clinical state of irreversible decline with a life expectancy of less than weeks or months, according to medical criteria.

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Conditions

The condition(s) this trial relates to.

Frailty Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging Biomarkers / blood Cellular senescence Exercise Frailty

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Navarrabiomed

    Pamplona, Navarre, 31001, Spain

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