FRAILTY

This study tests a 24-week home program called FITWISE for adults aged 60 and older who are frail or pre-frail. Participants will exercise with a video game system, with or without extra support from a family caregiver. The goal is to see if the program is practical and can impro…

This study tests whether a volunteer-led lifestyle program can improve muscle mass, strength, and mobility in older adults with or at risk of sarcopenia (age-related muscle loss). Two hundred people aged 60 and older will be randomly assigned to the program or usual care. The pro…

This study tests whether a digital prehabilitation app (HEAL-ME) combined with creatine and whey protein supplements can help maintain muscle health and reduce frailty in people with cirrhosis. About 100 participants will use the app and take supplements for at least 3 months. Th…

This study compares two treatments for elderly frail patients with atrial fibrillation (AFib) who are at high risk for both stroke and bleeding. One group gets a heart procedure (catheter ablation) plus a device to close off a part of the heart (left atrial appendage occlusion), …

This study tests a program that combines physical exercises with mental tasks (like walking while doing a puzzle) for frail adults aged 65 and older. The goal is to see if it improves their physical function, thinking skills, and overall frailty compared to standard care. About 2…

This pilot study will test whether a program that combines physical exercises with non-immersive virtual reality can improve balance, thinking, and daily activities in adults aged 65 and older. About 60 participants will be split into three groups: one doing combined exercise and…

This study will test whether a virtual reality exercise program (PABLO) is better than standard physiotherapy (Otago) at improving balance and reducing falls in adults aged 45 and older who have fallen before or have balance issues. About 80 participants will do 12 weeks of super…

This study tests whether a smartphone app that guides patients through exercises, nutrition tracking, and mood check-ins before cancer surgery can improve their physical function and reduce anxiety. About 60 adults scheduled for elective cancer surgery will either use the app or …

This study tests a home strengthening program for adults aged 65 and older who have sarcopenia (muscle loss) or frailty. Participants use a Bluetooth-connected resistance band and app that gives real-time feedback, while a doctor monitors progress remotely. The goal is to see if …

This study tests whether an 8-week tele-rehabilitation program can improve muscle mass, reduce frailty, and enhance quality of life in adults with cystic fibrosis. Participants will do supervised exercise sessions from home three times a week. The goal is to see if remote trainin…

This study looks at whether two different exercise programs can improve physical function, balance, and mental well-being in older adults aged 60 and over living in Angola. A total of 350 participants will be randomly assigned to either a multicomponent exercise program or a simp…

This study tests whether a 10-week program combining strength training with muscle relaxation exercises can reduce frailty, anxiety, and burden in people caring for a loved one with Alzheimer's. Researchers will compare this combined approach to relaxation alone in 62 adult careg…

This study tests whether a program run by nursing and sports science students can help older adults in nursing homes become less frail. Sixty participants will be split into two groups: one gets the student-led program, the other gets usual care. The goal is to see if the program…

This study looks at how HIV might speed up aging. Researchers will compare frailty, muscle loss, nutrition, thinking, and physical function in 80 adults aged 40 and older—half with HIV and half without. The goal is to understand if people with HIV face these age-related problems …

This study looks at whether an AI system that analyzes emotions in a person's voice can help predict frailty and improve mental health in adults with congenital heart disease. Over three years, 410 participants will complete surveys and some will receive AI-guided counseling. The…

This study looks at whether a detailed health check called a kidney transplant-specific comprehensive geriatric assessment (KT-CGA) can help older adults (60+) with advanced kidney disease get a fairer evaluation for a kidney transplant. About 50 participants will either receive …

This study looks at how frailty—a state of increased weakness and vulnerability—affects the quality of life in women aged 60 and older who have been newly diagnosed with breast cancer. Researchers will track 100 participants over 6 months using questionnaires to measure well-bein…

This study looks at whether a simple frailty score (ISAR) can identify older adults in the emergency department who are at risk for medication problems, like harmful drug interactions or inappropriate prescriptions. Researchers will collect medical data from 300 patients aged 75 …

This study will observe 228 elderly patients (65+) with a broken femur and high frailty to see if giving them a nutritional drink before surgery leads to better outcomes. Researchers will compare those who get the drink with those who follow standard care, tracking heart stabilit…

This study watches how sarcopenia (muscle loss) and frailty affect the drug rocuronium, a muscle relaxant used during surgery, in 100 older adults. Researchers will measure how fast the drug works and how long it lasts. The goal is to help doctors give safer anesthesia to elderly…

This study looks at 100 elderly patients with hip fractures to see if easy, quick tests like muscle ultrasound, handgrip strength, and routine blood work can predict frailty. Frailty affects recovery after surgery, so finding a fast way to measure it could help doctors plan safer…

This study looks at a new way to offer vaccines to adults with chronic illnesses or weakened immune systems while they are in the hospital. The goal is to see if offering vaccines during hospital visits helps more people get vaccinated. Researchers will track how many patients ar…

This study will follow 4,000 intensive care patients aged 80 and older to see how chronic and acute heart conditions impact their long-term recovery and quality of life. Researchers will track survival, frailty, and daily functioning using simple tests. The goal is to better pred…

This study looks at the health, nutrition, and daily living abilities of adults aged 60 and older living in a rural village in Assiut, Egypt. Researchers will interview participants and do simple physical checks to understand common health problems and risks. No treatments are gi…

This study looks at whether a detailed health check-up (called eCGA) can help doctors better understand and manage frailty in adults aged 65 and older. About 120 participants will be followed for 12 months, and some will also get a personalized exercise program. The goal is to se…

This study explores whether frailty can help predict bleeding risk in older adults (65+) who have had a heart attack or unstable angina. Researchers will follow 850 participants for up to 6 months to see if adding frailty to standard risk tools improves predictions. The goal is t…

This study tests whether a health tracking platform can improve frailty in 1,000 seniors over 65 over one year. Researchers also want to find the best ways to predict frailty so doctors can prevent it earlier. The study is not yet recruiting.

This study looks at whether older adults with mild thinking or memory problems are more likely to become confused after planned hip replacement surgery. About 400 people aged 65 and older will take a short thinking test before surgery and be checked for confusion for three days a…

This study looks at how frailty—a state of reduced strength and health—impacts treatment choices and short-term results in people aged 65 and older who have had a heart attack. Researchers will follow 645 participants for 30 days to see if adding frailty checks to standard risk s…

This study checks if a short questionnaire called G8 can accurately identify frailty in people aged 70 and older with solid tumors. Researchers will compare the G8 results with a full geriatric assessment in 150 participants. The goal is to see if the G8 tool works well for Portu…

This pilot study tests a 12-week telehealth program for frail adults aged 65 and older who have just left the hospital. The program uses activity sensors and pedometers to support physical and mental recovery at home. Researchers will check if the program is practical and liked b…