Can a hormone drug boost exercise benefits for aging HIV patients?

NCT ID NCT06554717

Recruiting now Disease control Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether adding tesamorelin (a growth-hormone-releasing hormone analogue) to a home-based exercise program can improve physical function in 100 adults aged 50-80 with HIV. Participants are randomly assigned to receive tesamorelin or a placebo injection daily for 24 weeks, while all follow a supervised exercise routine. The study measures changes in chair stand time, muscle strength, and quality of life, and will also see if benefits last after treatment stops.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Tesamorelin (a growth-hormone-releasing hormone analogue, also known as Egrifta)
What this could lead to: If it works, this could point toward a way to help people aging with HIV maintain strength and mobility, potentially improving quality of life.
What could go wrong: This is a phase 2 trial with only 100 participants, so results are preliminary. Tesamorelin is already approved for abdominal fat in HIV, but its effect on physical function is unproven, and the exercise component may be hard to sustain.

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Conditions

The condition(s) this trial relates to.

Frailty HIV infectious disease Obesity, Abdominal

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ABDOMINAL OBESITY AGING FRAILTY HIV-1-INFECTION IMPAIRED PHYSICAL FUNCTION

Contacts and locations

Locations

Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
University of Colorado - Anschutz Medical Campus
RECRUITING

Aurora, Colorado, 80045, United States

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