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HIV pill breakthrough: 4-Day week works as well as daily dosing

NCT ID NCT03256422

Completed Disease control Sponsor: ANRS, Emerging Infectious Diseases Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether people with well-controlled HIV can safely take their antiretroviral drugs only 4 days in a row each week, instead of every day. Over 600 adults with stable HIV participated. The main goal was to see if the 4-day schedule kept the virus suppressed just as well as daily treatment. Results showed that the shorter schedule was non-inferior, meaning it worked nearly as well, potentially reducing pill burden and side effects.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV INFECTIONS

Contacts and locations

Locations

  • Antoine Beclère

    Clamart, 92140, France

  • Avicenne

    Bobigny, 93000, France

  • Bicêtre

    Le Kremlin-Bicêtre, 94275, France

  • CHD de la Roche Sur Yon

    La Roche-sur-Yon, 85295, France

  • CHI de Créteil

    Créteil, 94010, France

  • CHRU Jean Minjoz

    Besançon, 25030, France

  • CHU Pointe-à-Pitre

    Pointe à Pitre, Guadeloupe, 97159, France

  • Centre Hospitalier Général de Saint Nazaire

    Saint-Nazaire, 44600, France

  • Centre Hospitalier Intercommunal

    Villeneuve-Saint-Georges, 94195, France

  • Centre Hospitalier René Dubos

    Pontoise, 95301, France

  • Centre Hospitalier de Perpignan

    Perpignan, 66046, France

  • Centre Hospitalier de Saint-Brieuc

    Saint-Brieuc, 22000, France

  • Centre Hospitalier du Mans

    Le Mans, 72037, France

  • Centre hospitalier Annecy Genevois

    Pringy, 74374, France

  • Centre hospitalier Victor Dupouy

    Argenteuil, 95100, France

  • Centre hospitalier sud francilien

    Corbeil-Essonnes, 91106, France

  • Hôpital Ambroise Paré

    Boulogne-Billancourt, 92104, France

  • Hôpital André Mignot

    Versailles, 78157, France

  • Hôpital Bichat

    Paris, 75018, France

  • Hôpital Bretonneau

    Tours, 37044, France

  • Hôpital Carémeau

    Nîmes, 30029, France

  • Hôpital Civil

    Strasbourg, 67091, France

  • Hôpital Delafontaine

    Saint-Denis, 93205, France

  • Hôpital Dupuytren

    Limoges, 87042, France

  • Hôpital Edouard Herriot

    Lyon, 69437, France

  • Hôpital Emile Müller

    Mulhouse, France

  • Hôpital Européen

    Marseille, 13331, France

  • Hôpital Européen Georges Pompidou

    Paris, 75908, France

  • Hôpital Foch

    Suresnes, 92151, France

  • Hôpital Gabriel Montpied

    Clermont-Ferrand, 63003, France

  • Hôpital Gui de Chauliac

    Montpellier, 34295, France

  • Hôpital Gustave Dron

    Tourcoing, 59208, France

  • Hôpital Henri Duffaut

    Avignon, 84000, France

  • Hôpital Henri Mondor

    Créteil, 94010, France

  • Hôpital La Grave

    Toulouse, 31059, France

  • Hôpital La Meynard Zobda Quitman

    Fort-de-France, Martinique, 97261, France

  • Hôpital Louis Pasteur

    Chartres, 28630, France

  • Hôpital Michallon

    Grenoble, 38043, France

  • Hôpital Necker

    Paris, 75015, France

  • Hôpital Nord

    Saint-Etienne, 42055, France

  • Hôpital Pellegrin

    Bordeaux, 33076, France

  • Hôpital Pitié-Salpêtrière

    Paris, 75651, France

  • Hôpital Pontchaillou

    Rennes, 35033, France

  • Hôpital Purpan

    Toulouse, 31059, France

  • Hôpital Raymond Poincaré

    Garches, 92380, France

  • Hôpital Robert Debré

    Reims, 51100, France

  • Hôpital Saint-André

    Bordeaux, 33075, France

  • Hôpital Saint-Antoine

    Paris, 75012, France

  • Hôpital Saint-Louis

    Paris, 75475, France

  • Hôpital Sainte Marguerite

    Marseille, 13274, France

  • Hôpital de Brabois

    Vandœuvre-lès-Nancy, 54511, France

  • Hôpital de La Source

    Orléans, 45100, France

  • Hôpital de l'Archet

    Nice, 06202, France

  • Hôpital de l'Hôtel Dieu

    Nantes, 44093, France

  • Hôpital de l'Hôtel Dieu

    Paris, 75181, France

  • Hôpital de la Croix Rousse

    Lyon, 69000, France

  • Hôpital de la Côte de Nacre

    Caen, 14033, France

  • Hôpital du Bocage

    Dijon, 21079, France

  • Hôtel-Dieu

    Paris, 75181, France

  • Institut hospitalier franco-britannique

    Levallois-Perret, 92309, France

  • Jean Verdier

    Bondy, 93143, France

  • Lariboisière

    Paris, 75475, France

  • Tenon

    Paris, 75970, France

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