HIV switch study: which combo works best after First-Line failure?
NCT ID NCT00931463
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested two different drug combinations for people with HIV whose first treatment stopped working. 558 participants received either standard second-line drugs plus a newer integrase inhibitor (raltegravir) or the standard second-line drugs alone. The main goal was to see which combination better suppressed the virus after 48 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ritonavir-boosted lopinavir and raltegravir
What this could lead to
If successful, this could show that adding raltegravir is as good as or better than continuing standard nucleoside drugs for people whose first HIV treatment stopped working.
What could go wrong
This is a completed Phase 4 trial, so results are already known. The main risk is that the new combination may not be more effective or may cause different side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Albion Street Centre
Sydney, New South Wales, 2010, Australia
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Auckland Hospital
Grafton, Auckland, 1, New Zealand
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CAICI
Buenos Aires, Rosario Provincia de Sante Fe, 2000, Argentina
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Centre Clinic
Melbourne, Victoria, 3182, Australia
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Chelsea and Westminster Hospital
Fulham, London, SW10 9NH, United Kingdom
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Chris Hani Baragwanath Hospital
Soweto, South Africa
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Desmond Tutu HIV Foundation
Cape Town, South Africa
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Evangel Hospital (ECWA)
Jos, Plateau State, Nigeria
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FUNCEI
Buenos Aires, Argentina
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Hopital Saint-Louis
Paris, France
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Hospital Almenara
Lima, Peru
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Hospital Central
Mendoza, 5500, Argentina
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Hospital General de Agudos 'Teodoro Alvarez'
Buenos Aires, 1406, Argentina
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Hospital General de Guadalajara
Guadalajara, Mexico
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Hospital General de Leon
León, Mexico
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Hospital Interzonal General de Agudos, Oscar Alende
Buenos Aires, Mar Del Plata Provincia, 1900, Argentina
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Hospital Italiano
Buenos Aires, Argentina
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Hospital J.M. Ramos Mejia
Buenos Aires, Argentina
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Hospital Pelau Pinang
Kuala Lumpur, Malaysia
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Hospital Prof. Alejandro Posadas
Buenos Aires, Argentina
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Hospital Rawson
Córdoba, Argentina
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Hospital San Borja-Arriaran
Santiago, Chile
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Hospital Sungai Buloh
Kuala Lumpur, Malaysia
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Hospital de Infecciosas FJ Muniz
Buenos Aires, Argentina
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Hospital de la Universidad Catolica Pontificia
Santiago, Chile
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IMPACTA/Hospital Dos de Mayo
Lima, Peru
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Institute of Infectious Diseases
Pune, Pune, India
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Instituto Nacional de Ciencias Medicas y Nutricion "Salvado Zubiran"
Mexico City, Mexico
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Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia
Lima, Peru
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J W Goethe Universitat
Frankfurt, Germany
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Jos University Teaching Hospital (JUTH)
Jos, Plateau State, Nigeria
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Josha Research
Bloemfontein, South Africa
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Liverpool Hospital
Liverpool, New South Wales, 2170, Australia
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Mater Misericordiae-Dublin
Dublin, Ireland
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Medical Group Practice
Berlin, Germany
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National Taiwan University Hospital
Taipei, Taiwan
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Plateau State Specialist Hospital
Jos, Plateau State, Nigeria
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Queen Elizabeth Hospital
Hong Kong, Kowloon, Hong Kong
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St Vincent's Hospital
Sydney, New South Wales, 2010, Australia
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Tan Tock Seng Hospital
Singapore, 308433, Singapore
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The Alfred Hospital
Melbourne, Victoria, 3004, Australia
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University of Malaysia
Kuala Lumpur, Malaysia
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Via Libre
Lima, Peru
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YRG Care
Chennai, India