New antibody shot aims to shield vulnerable patients from COVID-19

NCT ID NCT05648110

Completed Prevention Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested an experimental antibody called AZD3152 to see if it can safely prevent COVID-19 in people with weakened immune systems. About 3,882 adults received either the antibody or a placebo/comparator. The goal was to measure how well the antibody neutralizes the virus and prevents symptomatic COVID-19. The trial has completed, and results are pending.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

AZD3152 (a monoclonal antibody injection)

What this could lead to

If successful, this could provide a preventive option for people with weakened immune systems who may not respond well to vaccines.

What could go wrong

The trial is completed but results are not yet published. The antibody may not protect against future virus variants, and side effects are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

COVID-19 prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID-19, SARS-COV-2

Contacts and locations

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Locations

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Birmingham, Alabama, 35209, United States
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Birmingham, Alabama, 35215, United States
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Mobile, Alabama, 36608, United States
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Glendale, Arizona, 85306, United States
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Mesa, Arizona, 85206, United States
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Mesa, Arizona, 85210, United States
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Tucson, Arizona, 85712, United States
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Little Rock, Arkansas, 72205, United States
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Colton, California, 92324, United States
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La Mesa, California, 91942, United States
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Long Beach, California, 90815, United States
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Los Angeles, California, 90027, United States
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Modesto, California, 95350, United States
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Sacramento, California, 95817, United States
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Tustin, California, 92780, United States
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Westminster, California, 92683, United States
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Aurora, Colorado, 80014, United States
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Denver, Colorado, 80209, United States
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Denver, Colorado, 80246, United States
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Fort Collins, Colorado, 80525, United States
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New Haven, Connecticut, 06519, United States
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Washington D.C., District of Columbia, 20007, United States
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Coral Gables, Florida, 33134, United States
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Fleming Island, Florida, 32003, United States
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Fort Myers, Florida, 33912, United States
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Hollywood, Florida, 33024, United States
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Jacksonville, Florida, 32216, United States
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Jacksonville, Florida, 32256, United States
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Lake Worth, Florida, 33462, United States
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Largo, Florida, 33777, United States
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Lauderdale Lakes, Florida, 33313, United States
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Leesburg, Florida, 34748, United States
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Medley, Florida, 33166, United States
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Miami, Florida, 33125, United States
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Miami, Florida, 33126, United States
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Miami, Florida, 33135, United States
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Miami, Florida, 33186, United States
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Miami Lakes, Florida, 33014, United States
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Miami Springs, Florida, 33166, United States
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North Miami Beach, Florida, 33162, United States
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Orlando, Florida, 32806, United States
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Ormond Beach, Florida, 32174, United States
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Port Orange, Florida, 32127, United States
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St. Petersburg, Florida, 33713, United States
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Winter Park, Florida, 32789, United States
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Atlanta, Georgia, 30342, United States
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Columbus, Georgia, 31904, United States
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Boise, Idaho, 83712, United States
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Burr Ridge, Illinois, 60527, United States
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Chicago, Illinois, 60612, United States
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Chicago, Illinois, 60640, United States
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Gurnee, Illinois, 60031, United States
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Evansville, Indiana, 47712, United States
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Evansville, Indiana, 47715, United States
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South Bend, Indiana, 46617, United States
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West Des Moines, Iowa, 50266, United States
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Overland Park, Kansas, 66204, United States
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Wichita, Kansas, 67214, United States
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Bowling Green, Kentucky, 42101, United States
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Lexington, Kentucky, 40503, United States
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Lexington, Kentucky, 40509, United States
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Lake Charles, Louisiana, 70605, United States
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Metairie, Louisiana, 70006, United States
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New Orleans, Louisiana, 70119, United States
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Baltimore, Maryland, 21287, United States
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Boston, Massachusetts, 02115, United States
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Boston, Massachusetts, 02215, United States
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Methuen, Massachusetts, 01844, United States
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Springfield, Massachusetts, 01107, United States
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Worcester, Massachusetts, 01655, United States
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Detroit, Michigan, 48202, United States
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Farmington Hills, Michigan, 48334, United States
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Grand Rapids, Michigan, 49525, United States
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Novi, Michigan, 48377, United States
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Saint Clair Shores, Michigan, 48081, United States
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Minneapolis, Minnesota, 55446, United States
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Jefferson City, Missouri, 65109, United States
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Kansas City, Missouri, 64114, United States
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St Louis, Missouri, 63110, United States
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St Louis, Missouri, 63131, United States
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Missoula, Montana, 59808, United States
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Lincoln, Nebraska, 68516, United States
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Las Vegas, Nevada, 89119, United States
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Portsmouth, New Hampshire, 03801, United States
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Hackensack, New Jersey, 07601, United States
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Albuquerque, New Mexico, 87109, United States
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Buffalo, New York, 14202, United States
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Ridgewood, New York, 11385, United States
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Rochester, New York, 14607, United States
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Rochester, New York, 14642, United States
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Charlotte, North Carolina, 28208, United States
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Durham, North Carolina, 27710, United States
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Monroe, North Carolina, 28112, United States
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Morehead City, North Carolina, 28557, United States
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Wilmington, North Carolina, 28403, United States
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Cincinnati, Ohio, 45267, United States
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Westlake, Ohio, 44145, United States
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Allentown, Pennsylvania, 18103, United States
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Duncansville, Pennsylvania, 16635, United States
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Harrisburg, Pennsylvania, 17110, United States
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Philadelphia, Pennsylvania, 19104, United States
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Philadelphia, Pennsylvania, 19107, United States
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Pittsburgh, Pennsylvania, 15232, United States
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Providence, Rhode Island, 02903, United States
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Myrtle Beach, South Carolina, 29572, United States
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North Charleston, South Carolina, 29405, United States
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Rock Hill, South Carolina, 29732, United States
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Spartanburg, South Carolina, 29303, United States
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Knoxville, Tennessee, 37909, United States
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Austin, Texas, 78745, United States
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Dallas, Texas, 75246, United States
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El Paso, Texas, 79925, United States
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Houston, Texas, 77054, United States
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Houston, Texas, 77065, United States
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Houston, Texas, 77070, United States
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Houston, Texas, 77081, United States
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Houston, Texas, 77089, United States
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Kingwood, Texas, 77339, United States
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Mesquite, Texas, 75150, United States
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San Angelo, Texas, 76904, United States
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San Antonio, Texas, 78229, United States
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Shenandoah, Texas, 77384, United States
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Layton, Utah, 84041, United States
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Salt Lake City, Utah, 84115, United States
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Annandale, Virginia, 22003, United States
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Norfolk, Virginia, 23502, United States
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Norfolk, Virginia, 23507, United States
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Olympia, Washington, 98506, United States
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Seattle, Washington, 98109, United States
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Madison, Wisconsin, 53715, United States
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Melbourne, 3000, Australia
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Melbourne, 3004, Australia
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Murdoch, 6150, Australia
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Parkville, 3050, Australia
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Raymond Terrace, 4101, Australia
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Sippy Downs, 4556, Australia
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West Perth, 6005, Australia
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Alken, 3570, Belgium
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Liège, 4000, Belgium
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Montreal, Quebec, H2X 0A9, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Aalborg, 9100, Denmark
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Aarhus, 8200, Denmark
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Hvidovre, 2650, Denmark
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Roskilde, 4000, Denmark
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Svendborg, DK-5700, Denmark
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Dijon, 21079, France
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La Roche-sur-Yon, 85925, France
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Lille, 59037, France
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Nantes, 44093, France
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Nîmes, 30029, France
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Paris, 75014, France
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Paris, 75475, France
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Poitiers, 86000, France
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Saint-Etienne, 42055, France
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Strasbourg, 67091, France
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Toulouse, 31059, France
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Tours, 37000, France
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Cologne, 50924, Germany
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Essen, 45147, Germany
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Hamburg, 20095, Germany
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Hanover, 30625, Germany
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Mainz, 55131, Germany
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Petah Tikva, 49100, Israel
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Ramat Gan, 52621, Israel
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Kuala Lumpur, 56000, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Kuching, 93586, Malaysia
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Seberang Jaya, 13700, Malaysia
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Sunway City, 47500, Malaysia
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Krakow, 30-727, Poland
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Skórzewo, 60-185, Poland
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Singapore, 117599, Singapore
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Singapore, 169608, Singapore
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Singapore, 308442, Singapore
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Gyeonggi-do, 13620, South Korea
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Seoul, 03080, South Korea
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Seoul, 08308, South Korea
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Seoul, 5505, South Korea
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Badalona, 08916, Spain
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Barcelona, 08035, Spain
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Barcelona, 08036, Spain
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Barcelona, 08041, Spain
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Córdoba, 14004, Spain
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Madrid, 28007, Spain
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Madrid, 28031, Spain
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Madrid, 28040, Spain
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Marbella (Málaga), 29603, Spain
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Mérida, 06800, Spain
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Pozuelo de Alarcón, 28223, Spain
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Valladolid, 47003, Spain
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Vigo, 36312, Spain
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Taichung, 40447, Taiwan
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Taipei, 11490, Taiwan
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Bangkok, 10400, Thailand
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Bangkok, 10700, Thailand
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Khon Kaen, 40002, Thailand
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Muang, 11000, Thailand
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Muang, 50200, Thailand
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Abu Dhabi, 2951, United Arab Emirates
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Abu Dhabi, 34555, United Arab Emirates
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Bristol, BS2 8DX, United Kingdom
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Edinburgh, EH4 2XU, United Kingdom
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Harrow, HA1 3UJ, United Kingdom
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Leeds, LS9 7TF, United Kingdom
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Liverpool, L7 8XP, United Kingdom
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London, SE1 7EH, United Kingdom
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London, W1T 7HA, United Kingdom
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Manchester, M8 5RB, United Kingdom
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Oxford, OX3 7LA, United Kingdom
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Sheffield, S10 2JF, United Kingdom
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Torpoint, PL11 2TB, United Kingdom
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Truro, TR1 3LJ, United Kingdom
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Hanoi, 100000, Vietnam
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Hochiminh City, 700000, Vietnam