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Could a simple gas help ventilated COVID-19 patients breathe easier?

NCT ID NCT04306393

Completed Disease control Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether breathing in nitric oxide gas can improve oxygen levels in severely ill COVID-19 patients who are on ventilators. Researchers enrolled 200 adults in the ICU with confirmed COVID-19 and severe breathing problems. Patients received either standard care plus inhaled nitric oxide or standard care alone for up to 48 hours. The main goal was to see if the gas helped raise blood oxygen levels.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
inhaled nitric oxide gas
What this could lead to
If it works, this could provide a way to improve oxygen levels in severely ill COVID-19 patients on ventilators.
What could go wrong
This is a Phase 2 trial with 200 participants, so results are preliminary. The benefit may be modest or not apply to all patients, and nitric oxide can have side effects like methemoglobinemia.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Coronavinae infectious disease COVID-19 Orthocoronavirinae infectious disease severe acute respiratory syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONAVIRUS SARS (SEVERE ACUTE RESPIRATORY SYNDROME)

Contacts and locations

Locations

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • Danderyd Sjukhus AB

    Danderyd, Stockholm County, 18288, Sweden

  • Louisiana State University Health Shreveport

    Shreveport, Louisiana, 71103, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • University of Alabama

    Birmingham, Alabama, 35294, United States

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