Orthocoronavirinae infectious disease

This early-stage study is testing a new mRNA vaccine that aims to protect against both seasonal flu and COVID-19 with a single shot. Around 1,475 healthy adults aged 65 to 85 will receive either the new combo vaccine, a standard flu vaccine, or a licensed COVID-19 vaccine. Resear…

This early-stage trial is testing a new COVID-19 booster vaccine called OCU500, which is given as a nasal spray or inhaled mist instead of a shot. The study involves 80 healthy adults aged 18-64 who have already been vaccinated against COVID-19. Researchers are checking if the va…

This Phase 1 trial tests a new type of COVID-19 vaccine made from artificial antigen presenting cells (aAPC). The vaccine is designed to teach the body's T cells to recognize and attack the SARS-CoV-2 virus. The study includes healthy volunteers and people with mild COVID-19, and…

This trial tests a new vaccine called LV-SMENP, designed to teach the body's immune cells to recognize and attack the COVID-19 virus. The vaccine uses a harmless virus to deliver pieces of the coronavirus into dendritic cells, which then activate T cells to fight infection. The s…

This study tests a new COVID-19 vaccine called VYD2311, given alone or together with an existing mRNA COVID-19 vaccine, in healthy adults aged 18 to 49. The goal is to check safety and measure the body's virus-fighting antibody levels. Participants receive one injection and are m…

This study tests an updated COVID-19 vaccine (mRNA-1283) designed to protect against current virus variants. About 832 people aged 12 and older, especially those at higher risk, will receive the vaccine. Researchers will measure immune response and monitor for side effects to ens…

This study tests a new vaccine called GBP511, designed to protect against several sarbecoviruses (a group that includes SARS-CoV-2). About 368 healthy adults will receive one or two doses at different strengths, with or without an adjuvant to boost immune response. The goal is to…

This study tests several updated mRNA COVID-19 vaccines designed to target new variants of the virus. About 1,100 adults and children with certain risk factors will receive one of the vaccines to see how well it boosts immunity and how safe it is. The goal is to ensure vaccines r…

This early-stage trial is testing a new nasal spray vaccine called COV2 against COVID-19. Twenty healthy adults who have already had at least two COVID-19 shots will receive two doses of one of two formulations. The study aims to check if the vaccine is safe and whether it boosts…

This study tests a new COVID-19 vaccine that you breathe in as a mist, instead of getting a shot. It aims to see if it is safe and creates a strong immune response in the lungs and blood. About 350 healthy adults who have already had three mRNA COVID vaccines will receive either …

This study compares a new intranasal (nose spray) COVID-19 booster vaccine, LVT-001, with the standard mRNA booster shot in 238 healthy adults. The goal is to see if the nasal vaccine is safe and triggers a strong immune response, especially in the nose and throat where the virus…

This study tests two ways to encourage COVID-19 vaccination among Latino adults and their friends in Maryland. One group learns motivational interviewing skills to talk about vaccines, while the other just gets vaccine information. Researchers will compare how many friends get va…

This Phase 2a trial tests a new nasal COVID-19 vaccine (NDV-HXP-S-KP.2) against an approved mRNA shot in 200 adults who have already been vaccinated. The goal is to see if the nasal vaccine is safe and tolerable. Participants are either 65 or older, or 18-64 with a condition that…

This study is testing two experimental COVID-19 booster vaccines in 80 healthy volunteers aged 40-64. One vaccine includes an extra component called 's3' designed to improve the body's immune response. Participants will receive a single dose of either vaccine or a placebo and be …

This early-stage trial is testing whether a COVID-19 vaccine and a flu vaccine can be given together as a liquid under the tongue instead of a shot. About 100 adults will receive both vaccines over four months. The goal is to see if this approach is safe and triggers a strong imm…

This phase 3 trial tests a new antiviral pill, ibuzatrelvir, alone or with an IV drug (remdesivir) in 300 adults with weak immune systems who have mild-to-moderate COVID-19. The goal is to see if the combination prevents hospitalizations or worsening symptoms better than remdesiv…

This study tests an oral medication called ibuzatrelvir in adults and teens with COVID-19 who are not hospitalized but have a high risk of becoming severely ill. Participants will receive either the drug or a placebo for 5 days, and researchers will track whether it reduces emerg…

This study tests whether the antiviral drug molnupiravir can prevent severe illness from COVID-19 in adults at high risk. About 3,000 non-hospitalized participants will take either molnupiravir or a placebo for 5 days. The main goal is to see if the drug reduces hospitalizations,…

This study tests an experimental drug called DAS181 in people with weakened immune systems who have a serious lung infection caused by parainfluenza virus. The goal is to see if the drug helps them breathe without extra oxygen and reduces the risk of death. About 274 participants…

This early-stage trial tests a new drug called PRS CK STORM, made from a mix of immune and fat cells, to see if it can safely calm the 'cytokine storm'—a dangerous overreaction of the immune system—in people with severe lung infections from COVID-19, flu, or RSV. The study will e…

This study tests a new supplement called PNMR in 82 adults with long COVID. Participants either take PNMR plus standard care or standard care alone for 6 weeks. The main goal is to see if PNMR helps people walk farther in a 6-minute test. All participants also get diet and lifest…

This study looks at how obesity affects recovery from post-COVID conditions in older Veterans. Researchers will test if a weight loss program with diet and exercise can reduce inflammation and improve physical function and quality of life. The study involves 150 Veterans, some wi…

This study tests several potential COVID-19 treatments in adults to find safe doses and see if they help patients recover faster. It uses a flexible 'platform' design to add new drugs quickly. The trial includes people with mild to severe COVID-19 and focuses on reducing symptoms…

This study tests whether a drug called defibrotide is safe and feasible for people with severe COVID-19 pneumonia. About 42 adults with confirmed COVID-19 and lung infiltrates will receive the drug intravenously. Researchers will monitor for bleeding and low blood pressure as key…

This study tests whether baricitinib, a drug used for arthritis, can improve thinking, physical function, and quality of life in people with Long COVID. About 550 adults who had COVID-19 at least 6 months ago will receive either baricitinib or a placebo for 6 months. The main goa…

This large Phase 3 trial is testing many different treatments, including antiviral drugs and steroids, in 70,000 hospitalized patients with pneumonia (including COVID-19). The goal is to see which treatments reduce deaths and speed up recovery. Researchers compare each treatment …

This study tests whether using early drug monitoring and a dose-adjustment calculator can help infants under 90 days old with sepsis reach target vancomycin levels more quickly. Currently, doctors must wait 24-48 hours to check drug levels, which can delay effective treatment. Th…

This study tests whether giving arginine (a natural protein) by IV can improve how cells produce energy in children hospitalized with COVID-19. About 21 kids aged 3 to 21 will receive one of three doses three times a day for up to five days. Researchers will measure changes in mi…

This early-stage trial is testing whether genetically modified T-cells can safely control viral infections in cancer patients with weakened immune systems. The T-cells are designed to target specific viruses like CMV, BK virus, or COVID-19. The study involves 30 participants and …

This study tests whether special immune cells (called T cells) taken from a family member who already recovered from COVID-19 can safely treat mild to moderate COVID-19 in hospitalized adults. The cells are designed to attack the virus. The trial involves 50 participants and aims…

This study tests whether giving patients donor-derived immune cells (VSTs) on a regular schedule can prevent dangerous viral infections after a stem cell transplant. 180 participants will be randomly assigned to receive VSTs either on a fixed schedule or only when a virus is dete…

This study tests a new drug called AV-001 in 120 hospitalized adults with pneumonia who need extra oxygen. The drug is given daily for up to 28 days alongside standard care. The goal is to see if it is safe and helps patients recover faster from pneumonia caused by COVID-19 or ot…

This study looks at whether giving a longer course (10 days instead of 5) or adding another antiviral (remdesivir) to the standard Paxlovid treatment helps immunocompromised people clear COVID-19 faster. About 256 adults with mild or no symptoms will be randomly assigned to diffe…

This phase 2 trial is testing several antiviral drugs—including Paxlovid, molnupiravir, and older drugs like hydroxychloroquine—in 3,800 adults with mild COVID-19. Participants are randomly assigned to receive one of the treatments or no antiviral drug, and researchers measure ho…

This study is testing whether giving a longer course of the antiviral Paxlovid (10 days instead of 5) or combining it with another antiviral (remdesivir) helps immunocompromised people clear COVID-19 faster. About 256 participants with mild to moderate COVID-19 and weakened immun…

This study compares two ways of giving the antibiotic cefepime to very sick patients with sepsis in the ICU. The new method adjusts the dose based on the patient's kidney function, using only standard doses. The main goal is to see if this approach is easy for doctors to use and …

This phase 2 trial tests whether a drug called 2-HOBA can reduce immune system overactivity in people with Long COVID who also have POTS (a condition causing rapid heart rate upon standing). The study will enroll 50 participants and randomly assign them to receive either 2-HOBA o…

This study tests whether setting a breathing machine based on each patient's lung mechanics can lower the chance of death within 60 days for people with acute respiratory distress syndrome (ARDS). It includes both COVID-19 and non-COVID-19 patients. The approach is compared to st…

This study tests if the drug anakinra can help people with long COVID who have ongoing breathing issues and signs of an overactive immune system. About 182 adults will receive either anakinra or a placebo for up to 8 weeks. The goal is to see if the drug improves lung function, r…

This study tests whether specially grown donor immune cells (viral-specific T-cells) can safely treat viral infections that often occur after a stem cell transplant. These infections can be serious and sometimes don't respond to standard antiviral drugs. The approach aims to boos…

This study tests whether giving zinc supplements along with standard antibiotics can reduce deaths and improve recovery in young infants (0-59 days old) hospitalized with severe infections like sepsis or pneumonia. About 3,250 babies in Tanzania will receive either zinc or a plac…

This study tests whether an HMB-enriched amino acid supplement can reverse muscle loss and improve recovery in 48 patients with alcoholic liver disease and COVID-19 pneumonia. Participants receive either the HMB supplement or a balanced amino acid mix for 90 days. Researchers wil…

This study is testing whether giving high doses of vitamin D3 to critically ill patients with very low vitamin D levels can reduce the chance of death within 28 days. The trial will include 2,400 adults in intensive care units. If successful, this cheap and easy treatment could b…

This large Phase 3 trial is testing an experimental drug called tozorakimab in about 2,870 adults hospitalized with a viral lung infection who need extra oxygen. Participants receive either a single dose of tozorakimab or a placebo, added to standard care. The main goal is to see…

This program provides early access to the drug ruxolitinib for people with serious or life-threatening conditions like certain blood cancers, severe COVID-19, or graft-versus-host disease. It is for patients who have no other treatment options and cannot join a clinical trial. Th…

This study tests whether giving the antiviral drug remdesivir for 10 days can prevent severe COVID-19 in kidney transplant recipients who have mild or no symptoms. About 15 adults will receive the drug starting just before their transplant. The goal is to see if this approach all…

This study is testing a new, portable breath test called eBAM-CoV to see if it can detect COVID-19 as accurately as the standard nasal swab test (RT-PCR). The breath test is less invasive and gives immediate results. Researchers will compare the two tests in 250 adults who have s…

This early-stage study is testing a new radioactive tracer called 64Cu-FBP8 that lights up blood clots on a special PET-MR scan. Researchers want to see if it can safely and accurately detect clots in people with atrial fibrillation, COVID-19, or cancer. The study involves 165 pa…

This study is testing a breathalyzer kiosk that can detect COVID-19, flu, and RSV by analyzing a person's breath. About 100 adults, both with and without symptoms, will breathe into the device, and the results will be compared to standard nasal swab tests. The goal is to see if t…

This study is testing a new diagnostic panel called the BioFire ECoV Panel, designed to detect coronaviruses from leftover nose swab samples. Researchers will enroll 1,500 people and compare the panel's results to standard tests to see how accurate it is. The test is not being us…

This study checks if a new COVID-19 test (Metrix COVID Test) works well when used at home or in clinics. About 1,000 people with COVID symptoms will take the test, and results will be compared to a standard FDA-cleared test. The goal is to see if the new test accurately detects t…

This early-stage study is testing an experimental antibody called MDX2301 to see if it can help prevent severe COVID-19 in healthy adults and those at higher risk. About 80 participants will receive either the antibody or a placebo, given as an injection or infusion. The main goa…

This study tests whether community health workers can help adults with chronic illnesses get up-to-date on COVID-19 and flu vaccines. Participants receive up to three counseling sessions in English or Spanish to address their vaccine concerns. The goal is to reduce health dispari…

This massive study is tracking over 140,000 people who already take antihistamines (allergy meds) or amantadine (a Parkinson's drug) to see if these drugs protect against COVID-19. Researchers will measure how many get infected, need hospital care, or develop long COVID. The goal…

This study tests whether a pill called mitoquinone can prevent COVID-19 in healthy adults who have had close contact with someone who has COVID-19. About 112 participants will receive either the pill or a placebo. The goal is to see if it stops infection and reduces symptoms.

This early-stage study tests whether giving specially grown immune cells (called coronavirus-specific T cells) from a donor can safely prevent COVID-19 infection in people who recently had a stem cell transplant and have weak immune systems. About 24 adults and children will rece…

This study tests a program called Journey of Hope-C19 to see if it can prevent emotional and behavioral problems in children from low-income, minority communities who have faced both the COVID-19 pandemic and another major disaster. About 800 children in grades 3-8 will take part…

This study aims to reduce COVID-19 illness and death among people who live or work in prisons. Researchers will test different ways to encourage COVID-19 vaccination in Pennsylvania prisons, involving over 37,000 participants. The goal is to find what works best to increase vacci…

This study is testing whether a special heart-care plan, including better medication and exercise, can prevent heart failure in people over 50 who had COVID-19. Researchers will measure changes in exercise capacity and watch for new heart failure symptoms. The trial aims to enrol…

This study tests whether giving the COVID-19 vaccine (Comirnaty) to children starting at 6 months old can lower their chance of developing type 1 diabetes. The trial will include 2,252 children who have a high genetic risk for the disease. Half will get the vaccine, half a placeb…

This study is for primary caregivers in the Bronx who feel stressed. It tests a 12-week program called CARE, plus a phone app (Valera) that gives parenting tips and connects families to a care manager. The goal is to see if these tools can lower stress and help parents support th…

This study tests a home-based exercise program for people who were hospitalized with severe COVID-19. Participants use a smartphone app to guide them through high-intensity interval training and other exercises. The goal is to see if this approach improves walking ability, fitnes…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can improve thinking, memory, and other symptoms in people with long COVID. About 91 adults who have had cognitive problems for at least 3 months after a COVID infection will be ra…

This study compares two cognitive rehab programs for adults with long COVID who have mild to moderate brain fog. Both programs include computer games, in-lab training, and a mild nerve stimulation device worn on the ear. One group focuses on processing speed and work-related task…

This study tests whether an 8-week program of supervised physical and cognitive exercises can improve walking, thinking, strength, and quality of life in 374 adults with Long COVID and conditions like high blood pressure or diabetes. Participants are randomly assigned to either t…

This Phase 2 trial tests whether the drug plitidepsin can improve overall health in 90 adults with moderate-to-severe long COVID symptoms. Participants receive either plitidepsin or a placebo intravenously over four 3-day cycles, with a 90-day follow-up. The study is double-blind…

This study tests two at-home treatments—smell training and a gentle nerve stimulation device—for people with long COVID who have lost or distorted their sense of smell. About 145 adults will do daily sessions at home and attend three clinic visits over 12 weeks. The goal is to se…

This Phase 3 trial tests two repurposed drugs—upadacitinib and pirfenidone—against a placebo in 348 adults with Long COVID. Participants from six countries will take the drugs for three months to see if they ease symptoms like fatigue, breathing trouble, memory issues, muscle pai…

This study tests a small device that sends gentle electrical pulses to nerves in the ear to help children ages 11-18 with post-concussion syndrome or long COVID symptoms like pain, nausea, and balance problems. Participants must have had symptoms for at least 3 months. The goal i…

This study is testing whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can improve symptoms like fatigue and brain fog in people with post-COVID syndrome. About 40 adults with long COVID will receive the treatment. The main goal is to see if a la…

This study compares music-backed mindfulness meditation to meditation alone for reducing stress and anxiety in people of African descent. 70 participants with anxiety or depression will join virtual sessions. The goal is to see if adding music makes stress management more effecti…

This study tests a new drug, ratutrelvir, in adults with mild to moderate COVID-19 who are not in the hospital. About 90 participants will take the drug plus standard care to see if it is safe and helps symptoms go away faster. The goal is to find the right dose for future studie…

This study looks at how well seawater nasal sprays work in everyday life for people with nasal and sinus issues like colds, allergies, or after surgery. About 1065 people of all ages, including pregnant women, will use the sprays and report their symptoms. The goal is to see if t…

This study tests whether Astepro, an over-the-counter allergy nasal spray, can help manage early COVID-19 symptoms and reduce viral load. 280 adults with a positive COVID test will use the spray or a placebo for 10 days. Researchers will track symptoms, viral levels, and whether …

This study tests whether a home-based, supervised group exercise program can help high-risk Veterans recover their fitness after COVID-19. 80 Veterans with conditions like high blood pressure or diabetes will do guided workouts from home. The goal is to improve heart and lung fun…

This study tests whether virtual reality (VR) can help healthcare workers and COVID-19 patients with posttraumatic stress disorder (PTSD). Participants will use VR headsets during 10 therapy sessions over 5 weeks to safely revisit and overcome traumatic memories. The goal is to s…

This study tests whether a 60-second ultrasound pulse to the brain can improve thinking and memory in people with long COVID brain fog. Forty participants will receive either real or fake (sham) stimulation, and their cognitive performance will be measured before and after. The g…

This study aims to collect samples and medical information from people of all ages who have or have been exposed to viral infections, including COVID-19 and herpes. Researchers want to understand how viruses affect healthy individuals versus those with weakened immune systems. Pa…

This study looks at skin problems that appear during a COVID-19 infection, with a special focus on chilblains (painful red or purple bumps on fingers or toes). Researchers want to understand why these skin changes happen—whether from the virus itself, tiny blood clots, or inflamm…

This study looks at how the immune system changes with age and how that affects the risk of infections in people 60 and older. Researchers will collect blood, urine, stool, and other samples from elderly patients with infections and healthy older adults. By analyzing immune cells…

This study looks at heart health in children five years after they had MIS-C, a rare but serious condition linked to COVID-19. Researchers will compare 90 children who had MIS-C with healthy children of the same age and sex. They will use heart imaging, blood vessel checks, exerc…

This study enrolls healthy adults who are already part of a respiratory virus challenge study at the NIH. Participants wear a smartwatch and use a smartphone to track temperature, heart rate, coughs, and other health signals. The goal is to see if these devices can detect subtle …

This study is testing different methods to detect COVID-19 infections and measure immunity. Researchers will use PCR tests to find active infections and antibody tests to see who has been infected before. Up to 2500 volunteers, including staff and their families, will participate…

This study aims to find out how common anti-annexin A2 antibodies are in people hospitalized with COVID-19 and whether these antibodies are linked to lung damage or blood clots. Researchers will test blood samples from 300 adult patients at one hospital. The goal is to see if the…

This study aims to improve how doctors evaluate and manage people who have been exposed to bioterrorism agents (like anthrax) or emerging infectious diseases (like SARS or new flu strains). Up to 200 participants, including patients and healthcare workers, will be monitored and t…

This study follows 650 adults who had pneumonia (including COVID-19) to see how the infection might lead to heart disease later. Researchers will collect blood samples, run heart and lung tests, and track heart attacks, strokes, and other events over three years. No new treatment…

This study is testing a new rapid diagnostic device called In-Dx to quickly identify infections and antibiotic resistance in emergency patients with suspected sepsis. Researchers will compare the device's results to standard lab cultures using stored samples from 2,500 patients. …

This study looks at why some people had severe COVID-19 while others had mild symptoms. Researchers will compare the immune system's early response (called interferon) in 134 adults who were sick during the first wave. They also want to see if gut bacteria play a role. The goal i…

This study aims to find out whether people with long COVID still have inactive remnants of the SARS-CoV-2 virus in their bodies. Researchers will collect tissue samples from 12 adults who have recovered from COVID-19, some with long COVID symptoms and some without. The goal is to…

This study looks at how the COVID-19 pandemic impacted the emotional, financial, physical, and social well-being of adolescent and young adult (AYA) cancer patients and survivors. Researchers will survey 600 participants to measure COVID-related distress and changes in health beh…

This study in Malawi aims to understand why COVID-19 was much less severe there than in Europe and the Americas. Researchers will follow 1500 people, including those infected and their household contacts, to see how factors like prior infections, nutrition, and immune responses a…

This study is a registry that collects medical information from 1,000 COVID-19 patients treated at San Matteo Hospital in Italy. Researchers will analyze the data to find patterns linked to death during hospitalization. No new drug or treatment is being tested; the goal is to lea…

This study gives a single dose of kisspeptin, a natural hormone, to 40 people with and without Long COVID. Researchers will take frequent blood samples to measure how the brain's reproductive hormone system responds. The goal is to understand if Long COVID disrupts this system, w…

This study collects blood and nasal secretions from up to 2,000 people with COVID-19 to learn why some get very sick while others recover easily. Researchers will also track long-term symptoms like fatigue and brain fog. No treatments are tested—the goal is to gather data to guid…

This study examines the clinical and socioeconomic factors linked to suicidal behavior in children and adolescents during the COVID-19 pandemic in the Auvergne-Rhône-Alpes region of France. Researchers will collect data from 6,500 participants aged 8 to 17, including medical reco…

This study looks at whether having a respiratory infection in the past changes how your lungs react to ozone, a common air pollutant. One hundred healthy adults will breathe ozone while exercising and have their lung cells sampled. The goal is to understand why some people may be…

This study at Johns Hopkins Hospital is looking at how COVID-19 infection and mRNA vaccines (Pfizer or Moderna) affect pregnant women and their newborns. Researchers will collect blood, placenta, and breast milk samples from 300 participants to study immune responses and pregnanc…

This study uses a special PET-CT scan to track immune cells in people who have recovered from COVID-19. Up to 80 adults who had COVID-19 will get a tiny dose of a tracer to see where immune cells are active in their bodies. The goal is to learn more about how the immune system re…

This study is collecting medical information and biological samples from up to 6,000 people with COVID-19. Researchers want to find out which factors predict severe illness, death, or response to treatment. The goal is to better understand the disease and help guide future care.

This study looks at how serious respiratory infections (like flu, COVID-19, and RSV) affect the ability of adults aged 60 and older to live independently. Researchers will follow 1,600 hospitalized seniors across multiple countries to track changes in daily activities such as bat…

This study aims to understand why the protection from vaccines like those for COVID-19 fades over time. Researchers will follow 1,200 healthy adults for one year, collecting blood samples and health updates after they receive a vaccine or booster in their community. The goal is t…

This study aims to understand why some people continue to have symptoms like shortness of breath and fatigue long after a severe COVID-19 infection. Researchers will follow 67 adults for up to 12 months, using scans, blood tests, and other measures to look for clues in the lungs …

This study looks at how the COVID-19 pandemic impacted out-of-pocket costs, lost wages, and unemployment for 600 breast cancer patients undergoing surgery. Participants will fill out questionnaires about their financial experiences. The goal is to understand the financial toxicit…

This study aims to understand why some people lose their sense of smell after a COVID-19 infection and why it doesn't come back. Researchers will collect tiny tissue samples from the nose of 240 people—some with smell problems and some without—to look for differences in cells, in…

This study is a large international registry that will collect health information from 10,000 adults hospitalized with COVID-19. Researchers will track serious outcomes like death, heart failure, and kidney problems. The goal is to learn more about the course of the disease and i…

This study uses surveys and phone interviews to learn how COVID-19 impacts people with cancer. Researchers want to understand the challenges these patients face during the pandemic. About 50 adults with cancer will take part. No treatments or medications are involved.

This study aims to understand the long-term mental, physical, and social impacts of COVID-19 on minority women and their families in North Carolina. About 700 healthy women aged 18 and older who are African American, Hispanic, Native American, Asian American, or Pacific Islander …

This study aims to understand why some people get very sick from COVID-19 while others do not. Researchers will analyze blood samples and genetic information from 100 hospitalized adults with confirmed COVID-19. The goal is to identify immune system patterns and genetic factors l…

This study tests a new, lightweight ultrasound device called NeoDoppler that can be gently placed on a newborn's soft spot (fontanelle) to continuously measure blood flow in the brain. Researchers will enroll 180 preterm and full-term infants, including those with conditions like…

This study follows 650 adults in Quebec to learn about the short- and long-term health problems caused by COVID-19, including damage to the heart, lungs, kidneys, and other organs. Participants include people who had mild, moderate, or severe COVID-19, as well as those who never …

This study is looking at whether early signs of inflammation in the blood can help identify which patients with infections are at risk for serious complications like sepsis. Researchers will follow 4,200 adults with confirmed or suspected infections, as well as healthy controls, …

This study uses a 10-minute questionnaire to learn how the COVID-19 pandemic impacted the quality of life, mental health, finances, and social connections of people with melanoma. Researchers will also look at what factors, like social support, helped people cope. About 1,152 par…

This study compares the immune response to COVID-19 vaccines between people being treated for tuberculosis (TB) and healthy individuals. About 133 participants in the Thailand-Myanmar border area will receive one of three vaccines (Pfizer, AstraZeneca, or Janssen). Researchers wi…

This study follows 150 NIH staff members for about a year to see how their immune systems respond to flu and COVID-19 vaccines. Participants give monthly blood and nasal samples to measure antibodies in both the body and the nose. The goal is to understand how long immunity lasts…

This study looks at how common COVID-19 is among healthcare workers by testing for antibodies in their blood. It also checks their mental and emotional health during the pandemic. About 1,000 workers from NewYork-Presbyterian will take part. The goal is to learn how to better pro…

This study aims to collect blood, nose, and saliva samples from up to 20,000 people aged 3 and older who have or may have a respiratory virus infection like flu or COVID-19. The samples will be stored and used in future research to better understand these viruses and how the immu…

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This study looks at why some veterans experience ongoing brain fog and other mental health issues after COVID-19. Researchers will track 200 veterans over time, using memory tests and blood samples to find clues. The goal is to better understand these symptoms and identify target…

This study looks at whether basic vital signs like heart rate, blood pressure, and breathing rate can help doctors track how COVID-19 patients are doing. Researchers will review medical records of 15,000 patients treated between 2022 and 2027. The goal is to see if these simple m…

This study is working to create better exercise tests for children with cystic fibrosis, sickle cell disease, or long COVID. Current tests are designed for healthy athletes and may not be safe or useful for these kids. Researchers will track 240 children over 3-4 years, measuring…

This study looks back at 3,000 hospital patients to see if those who got a flu shot, took blood pressure meds (ACEI/ARB), antihistamines, or amantadine had better COVID-19 outcomes. Researchers want to know if these common treatments can reduce deaths or shorten hospital stays. N…

This study follows 1,350 people in Hong Kong households to see how their protection against COVID-19 changes over time. Researchers will measure antibodies from both vaccination and past infection. The goal is to understand how household immunity evolves and how it affects the ri…

This study collects blood samples from 1,500 adults, including cancer patients, healthy volunteers, and COVID-19 donors. Researchers aim to develop a device that can grow, select, and test immune cells (T cells) from the blood. The goal is to see if these cells can be trained to …

This study looks at how well the flu vaccine works in people who have had COVID-19, including those with long-term symptoms like fatigue or diabetes. Researchers will compare immune responses between 230 adults and children (ages 9-64) who had COVID-19 and those who did not. The …

This study looks at how the antibiotic ceftazidime avibactam behaves in 30 children with severe infections who are in intensive care, some on life support. Researchers will measure drug levels in the blood to understand the right dose. The goal is to improve treatment for life-th…

This study tracks the immune response of 300 people with confirmed flu or COVID-19, comparing those who were recently vaccinated to those who were not. Participants provide blood, saliva, and nasal samples over 6 months, and some may opt for a lung fluid sample via bronchoscopy. …

This study follows 1,590 adults who have had COVID-19 to track their symptoms and recovery over three years. Participants complete phone interviews and online surveys every three months. The goal is to describe the range of recovery experiences and identify factors that lead to p…

This study is testing whether giving the COVID-19 booster and flu vaccine at the same time is as good as giving them a month apart for people with weakened immune systems. It also compares getting a COVID-19 booster every 3 months versus every 6 months. The trial involves 660 adu…

This study aims to understand how changes in gut bacteria (dysbiosis) affect the immune system and gut health in people with long COVID. Researchers will collect stool and blood samples from 400 adults—half with long COVID symptoms and half without. The goal is to find links betw…

This study trains community health workers to create and share personal stories and infographics on social media to promote flu, COVID-19, and other respiratory virus vaccines. Researchers will survey the health workers' social media followers to see if the messages change their …

This study looks at 320 adults who are about to start strong immune-suppressing therapy and have already had at least two COVID-19 shots. Researchers want to find out if giving a COVID-19 booster right before starting therapy or waiting six months provides better protection. Part…

This study looks at how the antifungal medicine caspofungin behaves in children with severe infections, especially those with liver problems or on life support like ECMO. Researchers will measure drug levels in the blood to understand dosing needs. About 60 children in intensive …

This study will collect data from 2,000 children admitted to pediatric intensive care units (PICUs) with severe infections across major Chinese cities. Over 10 years, researchers will track which germs cause these infections, how they are treated, and patient outcomes. The goal i…

This study looks at two common antibiotic combinations given to hospitalized adults with infections: vancomycin plus piperacillin-tazobactam, or vancomycin plus cefepime. The goal is to see if one is less likely to cause kidney injury than the other, using more sensitive markers …

This study surveys pulmonologists across the US to understand how the COVID-19 pandemic changed their lung procedure practices, staffing, and operations. Researchers hope the findings will help guide future pandemic responses and improve care. About 250 doctors who are members of…

This study tests whether a virtual, community-based program combining music and mindfulness can help People of African Descent manage stress, anxiety, and depression during COVID-19. Researchers will measure brain activity and feelings of social connection in 48 participants as t…

This study reviews medical records from up to 400,000 U.S. Veterans to see how COVID-19 treatments like Paxlovid and remdesivir are used and how well they work. It also looks at RSV and flu patterns. The goal is to improve treatment strategies for respiratory viruses in the VA he…

This study surveys up to 20,000 employees of MD Anderson Cancer Center to understand how the COVID-19 pandemic affected their mental health and stress levels. Participants fill out questionnaires about stress and trauma-related symptoms. The goal is to identify which workers are …

This study uses an online survey to understand how medication use, self-medication, and other factors affect healthy aging in adults 18 and older. Researchers will look at drug interactions, polypharmacy (taking five or more medications), and genetic factors in a subgroup. The go…

This study, run by the National Institute of Allergy and Infectious Diseases, collects blood and stool samples from up to 5,000 people of all ages who have or had COVID-19, as well as those heavily exposed but uninfected. Researchers will analyze immune responses and genetic fact…

This study looks at how sleep issues and sleep apnea might affect thinking, memory, and daily life in people who had COVID-19. Researchers will follow 200 veterans for up to a year, testing their brain function, sleep quality, and exercise ability. The goal is to find out if trea…

This study uses cardiac MRI and other tests to examine heart and lung function in 510 COVID-19 survivors who had symptoms like shortness of breath or cough. The goal is to find out why some people have lasting cardiopulmonary problems after COVID-19. Participants will undergo ima…

This study looks at why some people develop a fast heart rate and dizziness months after COVID-19, a condition called post-COVID tachycardia syndrome. Researchers will measure immune markers and nerve activity in 60 participants to see if ongoing inflammation and reduced vagal ne…

This study trains medical students at the University of Sherbrooke to collect health data from 6,000 people in Quebec. Participants answer questions about lifestyle, access to health services, and other public health topics. The goal is to better understand health trends and help…

This study tests a training program for VA doctors to improve how they care for Veterans with Long-COVID. The training focuses on listening to patients, building a shared understanding of the condition, and creating a personalized care plan. About 348 Veterans and their doctors w…

This study will follow 30 adults who have received vaccines or antibody treatments for COVID-19 or monkeypox. Researchers will take blood and optional nasal swabs over time to measure how well the body's antibodies neutralize these viruses. The goal is to better understand how lo…

This study follows 200 adults with COVID-19 in intensive care to see how their immune systems change over time. Researchers will collect blood samples at several points during the hospital stay and track health outcomes. The goal is to understand why some patients get worse and t…

This study looks at why some people develop POTS (a condition causing rapid heartbeat and dizziness) after COVID-19. Researchers think a part of the nervous system that normally fights inflammation may not work well in these patients. They will compare 150 adults with and without…

This study follows 10,000 pregnant women in Nagpur, India, from early pregnancy through 42 days after birth. Researchers want to learn if catching flu or COVID-19 raises the risk of problems like preterm labor or severe pre-eclampsia. The goal is to provide clear evidence to help…

This study looks at 300,000 surgical patients in Stockholm to see how the COVID-19 pandemic impacted their recovery. Researchers will track deaths, complications, and how long people stayed in the hospital. The goal is to understand the pandemic's effects on surgical care, not to…

This study follows 345 adults to learn how COVID-19 may cause lasting damage to the lungs, heart, and kidneys. Researchers will compare people who had COVID-19 with those who did not, using blood tests, breathing tests, and heart scans. The goal is to find early warning signs and…

This pilot study is testing whether a smart wristband can accurately measure drug levels in sweat compared to standard blood tests. Researchers will collect sweat, saliva, and blood samples from 100 patients with chronic or infectious diseases who are taking medications like cycl…

This study follows about 800 people who have recovered from COVID-19 to learn how long the virus can stay in different parts of the body, such as the nose, stool, semen, and breast milk. Researchers will also track how the immune system responds and look for any long-term health …

This study aims to understand how common respiratory viruses like COVID-19, flu, and RSV spread in communities. Researchers will track up to 25,000 people of all ages using at-home test kits and symptom surveys. The goal is to better predict outbreaks and improve public health re…

This study follows 1500 adults who had COVID-19 to see how the virus affects their heart and lungs over time. Researchers will track inflammation markers and breathing problems using questionnaires. The goal is to learn more about recovery, not to test a treatment.

This study from Indiana University looks at how the COVID-19 pandemic may have changed people's physical activity, sleep, diet, blood pressure, and mental stress. Researchers will track 100 adults aged 18-75 using wearable devices, fitness tests, blood samples, and blood pressure…

This study is testing whether an artificial intelligence (AI) tool can help match cancer patients with the right clinical trials. Researchers will enroll up to 50,000 people with various cancers to see if the AI improves trial enrollment rates and patient outcomes. The goal is to…

This study is looking for new ways to diagnose sepsis, a life-threatening reaction to infection, earlier in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve diagno…

This registry is following 2,000 pregnant women who took antiviral drugs or monoclonal antibodies for COVID-19. Researchers will compare their pregnancy and baby outcomes to those who did not receive these treatments. The goal is to better understand the safety of these medicatio…

This study follows 6,000 pregnant women worldwide to compare health outcomes for those who received a COVID-19 vaccine during pregnancy versus those who did not. Researchers will track pregnancy complications, newborn health, and infant development up to 12 months old. The goal i…

This study looks at how pregnant and non-pregnant people recover after being in the intensive care unit (ICU) for severe COVID-19. Researchers will check for problems with movement, thinking, and mental health 3 to 6 months after leaving the ICU. The goal is to understand the lon…

This study follows 2,300 adults who had COVID-19 to learn why some develop long-term symptoms like fatigue, brain fog, or organ damage. Researchers will review medical records and track participants over time. The goal is to find patterns and predictors of post-COVID condition, w…

This study follows 1800 healthcare workers from eight countries for up to 24 months to see how their immune systems respond to COVID-19 vaccines and infections. Researchers will collect blood samples and health data to understand how different viral variants affect immunity. The …

This study follows 500 adults in France who have either a genetic defect or autoantibodies that weaken their type I interferon immune response. Researchers will collect blood samples and health data over 1 to 4 years to track infections, autoimmune diseases, and cancers. The goal…

This study follows 350 adults who had heart or chest surgery and tested positive for COVID-19 around the time of their operation. Researchers will track how well the heart and other organs recover, especially in the first 12 hours after surgery. The goal is to gather real-world d…

This study tests whether a clear plastic box placed over a patient's head during CPR can reduce the spread of viruses like COVID-19 to healthcare workers. Researchers will simulate cardiac arrest scenarios with 240 participants, measuring how well the box works during chest compr…