No needle needed? new trial tests oral COVID and flu vaccines together
NCT ID NCT06355232
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This early-stage trial is testing whether a COVID-19 vaccine and a flu vaccine can be given together as a liquid under the tongue instead of a shot. About 100 adults will receive both vaccines over four months. The goal is to see if this approach is safe and triggers a strong immune response.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Recombinant SARS-CoV-2 spike protein with Advax-CpG55.2 adjuvant and inactivated seasonal influenza vaccine with Advax-CpG55.2 adjuvant
What this could lead to
If successful, this could lead to a needle-free, combined COVID-19 and flu vaccine that is easier to administer and may boost immunity at the mucosal surfaces where viruses enter.
What could go wrong
This is a very early Phase 1 trial with only 100 participants, so safety and effectiveness are not yet proven. The oral route may not trigger strong enough immune responses compared to standard shots.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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ARASMI
RECRUITINGAdelaide, South Australia, 5042, Australia
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••