No needle needed? new trial tests oral COVID and flu vaccines together
NCT ID NCT06355232
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This early-stage trial is testing whether a COVID-19 vaccine and a flu vaccine can be given together as a liquid under the tongue instead of a shot. About 100 adults will receive both vaccines over four months. The goal is to see if this approach is safe and triggers a strong immune response.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Recombinant SARS-CoV-2 spike protein with Advax-CpG55.2 adjuvant and inactivated seasonal influenza vaccine with Advax-CpG55.2 adjuvant
- What this could lead to
- If successful, this could lead to a needle-free, combined COVID-19 and flu vaccine that is easier to administer and may boost immunity at the mucosal surfaces where viruses enter.
- What could go wrong
- This is a very early Phase 1 trial with only 100 participants, so safety and effectiveness are not yet proven. The oral route may not trigger strong enough immune responses compared to standard shots.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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ARASMI
RECRUITINGAdelaide, South Australia, 5042, Australia
Contact Email: •••••@•••••
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